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The map label for this gene is comP [H]

Identifier: 222095465

GI number: 222095465

Start: 1769902

End: 1771725

Strand: Direct

Name: comP [H]

Synonym: BCQ_1805

Alternate gene names: 222095465

Gene position: 1769902-1771725 (Clockwise)

Preceding gene: 222095464

Following gene: 222095466

Centisome position: 33.94

GC content: 27.19

Gene sequence:

>1824_bases
ATGGATTATTTGAAAGAATATATAAATGGGCTGTTACTATTAATTTTATCTCTTGTTCTTTTATCTTATTTTGTAAGTAC
CATTTTTCGGTATTCATTCACGGGTATTGAAGTTAAAAAATCAAATTCAATTTATTATACTACATATATTTATGAAAATA
CTTTGACTGCAAAAAACGGAATACAGGTAGGAGGCATTGTTAGAAAGGTTAACAATAAAGAACTAAATAAAAATATAAGA
TTAAAGACCTTTTTGAGAGTTGAAAAAATAGATACTATTGATATAATGCATAGGAATAACCTACTTAAATACCGAGTTTC
ATATGAAAAAGGTGATAAACAAAGAATGTATCATATAATATCTCCAACGATATTTACCCGTATAGTTTTATTTATTATAC
CAAATTTAATTTTAGATAAAGAGTTAATTACCTTTGAACTATCAGCAGTATGCTTCATTTTTATCCCCGTATACTCCCTG
TATATATTAATTTTAAAAAAATTTGATTTTGACTTAATTATAAATCGATTACAATACTATTTATTGATTTCTTTTGGAAT
TTCTGGTGTTTTATTTATAATTAACTTAATTATTTTTGAAAAAAGAAGAGAGAGTTTACTAGAAGTTATTCAATTCAATA
TTCTTATATATATTAGTATATTAATAGCACTTTATTTGAAAGACTATTTAGATTTTACCTTTCGCAAAATTTTATATAAT
CATAAAAAAAATTATACAAATAGCTTAAATCGTTTTATGCATCAGACAAAGAAAGAGTATGAAGTAAAAAAAATAATAAA
GTTTATCAAAAGAGAAGTGAAAGATGTTCTGAGCGTTACGAATCCTATATGTATTTCAGTCAATAATATGAGTAATAAAA
TAAGTTTTTTTGAAAAAGAACAAAGTATTTCTTTATCCAAATTACATAAATTTAATTGGAATAGTTATGGTATTGGTTCT
ATCATTTACATAGAAGGGTATTCTGTAATAGTAATTGCTATATTACCAGACTACCGTGTCGTACTATTAGCAAAGGGAAA
AAAATTTAATATCGATGAAATTGTATGGCTGGAGACCCTTGCTAACTATGCGAACCTTCAATTTGAATGTTTACGGAAAA
TAGAAATACTGGCAAAGAGTCTAGAACATGTAAATTTTGATACTAATTATCCAGCAGAGTATGCGCGATTTTCCTTTATG
ATTGCTGAAAAAGAACGTGAAAATTTGTCAAGAGATATACATGATGGCATTCTACAAGATCAATTACGCTTATATAGAAA
AATAGAGGTACGTGAAAAAAAAGAGACTAATGAAGAATTTAAAGTGACCTTACGGCAAATACGTGAACAAATAATAGATC
ATATATATATAACACGAGAAACATGTAATAATCTCAGACCTCCATTTTTAGAAGAATTAGGATTAGAAAAAGCGTTATTA
AATTTAATCAAAAAGATTAATCGAGAAGCAAATTTCTTGTTAGATTATAAAATTGAGAAAGAGTTGCGTATATATAATTC
AGAAATCAGTCATTGTATATATAGAGTTACACAAGAGTTATTAAATAATGCGATAAAACATTCACAAGCTACAGTAGTAA
AATTAAGGCTATTTGAGCAAAACAATTACCTTTGCTTATATTATGTTGATGACGGGATTGGCATGGGGATTGGGAAACAA
GTAGGAGATTTGAGATCAACCATAGGTATACCGGGAGTTATTGCTAGAGTAAGGGGATTACACGGTTCTGTTTCGATAGA
TAGCACTCATGGTAGTGGTGTACGCATAAAGATTAAATTTAACAAGGATAGTGTATATAAATAG

Upstream 100 bases:

>100_bases
TATTTAATTATGAATTCTATGATTCTTTTATTCTCTCTCATTATGTTAGATATAATTCAGCTGAAAAATATTTTTTTGGA
CTAAAATAGGTGAATCTGTA

Downstream 100 bases:

>100_bases
TACAAATGATAGAGAAGGTGAGAATAATATAATGATTCAAGTACTGATTATAGATGATCACCTAGCTGTTGGTATGGGAA
CAAAAGTATTAATAGAGCAA

Product: sensor protein comp

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MDYLKEYINGLLLLILSLVLLSYFVSTIFRYSFTGIEVKKSNSIYYTTYIYENTLTAKNGIQVGGIVRKVNNKELNKNIR
LKTFLRVEKIDTIDIMHRNNLLKYRVSYEKGDKQRMYHIISPTIFTRIVLFIIPNLILDKELITFELSAVCFIFIPVYSL
YILILKKFDFDLIINRLQYYLLISFGISGVLFIINLIIFEKRRESLLEVIQFNILIYISILIALYLKDYLDFTFRKILYN
HKKNYTNSLNRFMHQTKKEYEVKKIIKFIKREVKDVLSVTNPICISVNNMSNKISFFEKEQSISLSKLHKFNWNSYGIGS
IIYIEGYSVIVIAILPDYRVVLLAKGKKFNIDEIVWLETLANYANLQFECLRKIEILAKSLEHVNFDTNYPAEYARFSFM
IAEKERENLSRDIHDGILQDQLRLYRKIEVREKKETNEEFKVTLRQIREQIIDHIYITRETCNNLRPPFLEELGLEKALL
NLIKKINREANFLLDYKIEKELRIYNSEISHCIYRVTQELLNNAIKHSQATVVKLRLFEQNNYLCLYYVDDGIGMGIGKQ
VGDLRSTIGIPGVIARVRGLHGSVSIDSTHGSGVRIKIKFNKDSVYK

Sequences:

>Translated_607_residues
MDYLKEYINGLLLLILSLVLLSYFVSTIFRYSFTGIEVKKSNSIYYTTYIYENTLTAKNGIQVGGIVRKVNNKELNKNIR
LKTFLRVEKIDTIDIMHRNNLLKYRVSYEKGDKQRMYHIISPTIFTRIVLFIIPNLILDKELITFELSAVCFIFIPVYSL
YILILKKFDFDLIINRLQYYLLISFGISGVLFIINLIIFEKRRESLLEVIQFNILIYISILIALYLKDYLDFTFRKILYN
HKKNYTNSLNRFMHQTKKEYEVKKIIKFIKREVKDVLSVTNPICISVNNMSNKISFFEKEQSISLSKLHKFNWNSYGIGS
IIYIEGYSVIVIAILPDYRVVLLAKGKKFNIDEIVWLETLANYANLQFECLRKIEILAKSLEHVNFDTNYPAEYARFSFM
IAEKERENLSRDIHDGILQDQLRLYRKIEVREKKETNEEFKVTLRQIREQIIDHIYITRETCNNLRPPFLEELGLEKALL
NLIKKINREANFLLDYKIEKELRIYNSEISHCIYRVTQELLNNAIKHSQATVVKLRLFEQNNYLCLYYVDDGIGMGIGKQ
VGDLRSTIGIPGVIARVRGLHGSVSIDSTHGSGVRIKIKFNKDSVYK
>Mature_607_residues
MDYLKEYINGLLLLILSLVLLSYFVSTIFRYSFTGIEVKKSNSIYYTTYIYENTLTAKNGIQVGGIVRKVNNKELNKNIR
LKTFLRVEKIDTIDIMHRNNLLKYRVSYEKGDKQRMYHIISPTIFTRIVLFIIPNLILDKELITFELSAVCFIFIPVYSL
YILILKKFDFDLIINRLQYYLLISFGISGVLFIINLIIFEKRRESLLEVIQFNILIYISILIALYLKDYLDFTFRKILYN
HKKNYTNSLNRFMHQTKKEYEVKKIIKFIKREVKDVLSVTNPICISVNNMSNKISFFEKEQSISLSKLHKFNWNSYGIGS
IIYIEGYSVIVIAILPDYRVVLLAKGKKFNIDEIVWLETLANYANLQFECLRKIEILAKSLEHVNFDTNYPAEYARFSFM
IAEKERENLSRDIHDGILQDQLRLYRKIEVREKKETNEEFKVTLRQIREQIIDHIYITRETCNNLRPPFLEELGLEKALL
NLIKKINREANFLLDYKIEKELRIYNSEISHCIYRVTQELLNNAIKHSQATVVKLRLFEQNNYLCLYYVDDGIGMGIGKQ
VGDLRSTIGIPGVIARVRGLHGSVSIDSTHGSGVRIKIKFNKDSVYK

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71392; Mature: 71392

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLKEYINGLLLLILSLVLLSYFVSTIFRYSFTGIEVKKSNSIYYTTYIYENTLTAKNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEECEEECCCC
IQVGGIVRKVNNKELNKNIRLKTFLRVEKIDTIDIMHRNNLLKYRVSYEKGDKQRMYHII
CEECHHHHHCCCHHCCCCCEEEEEEEHHCCCEEEEEECCCEEEEEEECCCCCHHHHHHHH
SPTIFTRIVLFIIPNLILDKELITFELSAVCFIFIPVYSLYILILKKFDFDLIINRLQYY
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLISFGISGVLFIINLIIFEKRRESLLEVIQFNILIYISILIALYLKDYLDFTFRKILYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKKNYTNSLNRFMHQTKKEYEVKKIIKFIKREVKDVLSVTNPICISVNNMSNKISFFEKE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
QSISLSKLHKFNWNSYGIGSIIYIEGYSVIVIAILPDYRVVLLAKGKKFNIDEIVWLETL
CCCCHHHHHHCCCCCCCCCEEEEECCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHH
ANYANLQFECLRKIEILAKSLEHVNFDTNYPAEYARFSFMIAEKERENLSRDIHDGILQD
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
QLRLYRKIEVREKKETNEEFKVTLRQIREQIIDHIYITRETCNNLRPPFLEELGLEKALL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCCHHHHHCHHHHHH
NLIKKINREANFLLDYKIEKELRIYNSEISHCIYRVTQELLNNAIKHSQATVVKLRLFEQ
HHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
NNYLCLYYVDDGIGMGIGKQVGDLRSTIGIPGVIARVRGLHGSVSIDSTHGSGVRIKIKF
CCEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEECCCCCCEEEEEEE
NKDSVYK
CCCCCCC
>Mature Secondary Structure
MDYLKEYINGLLLLILSLVLLSYFVSTIFRYSFTGIEVKKSNSIYYTTYIYENTLTAKNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEECEEECCCC
IQVGGIVRKVNNKELNKNIRLKTFLRVEKIDTIDIMHRNNLLKYRVSYEKGDKQRMYHII
CEECHHHHHCCCHHCCCCCEEEEEEEHHCCCEEEEEECCCEEEEEEECCCCCHHHHHHHH
SPTIFTRIVLFIIPNLILDKELITFELSAVCFIFIPVYSLYILILKKFDFDLIINRLQYY
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLISFGISGVLFIINLIIFEKRRESLLEVIQFNILIYISILIALYLKDYLDFTFRKILYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKKNYTNSLNRFMHQTKKEYEVKKIIKFIKREVKDVLSVTNPICISVNNMSNKISFFEKE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
QSISLSKLHKFNWNSYGIGSIIYIEGYSVIVIAILPDYRVVLLAKGKKFNIDEIVWLETL
CCCCHHHHHHCCCCCCCCCEEEEECCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHH
ANYANLQFECLRKIEILAKSLEHVNFDTNYPAEYARFSFMIAEKERENLSRDIHDGILQD
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
QLRLYRKIEVREKKETNEEFKVTLRQIREQIIDHIYITRETCNNLRPPFLEELGLEKALL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCCHHHHHCHHHHHH
NLIKKINREANFLLDYKIEKELRIYNSEISHCIYRVTQELLNNAIKHSQATVVKLRLFEQ
HHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
NNYLCLYYVDDGIGMGIGKQVGDLRSTIGIPGVIARVRGLHGSVSIDSTHGSGVRIKIKF
CCEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEECCCCCCEEEEEEE
NKDSVYK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]