Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 222095139

GI number: 222095139

Start: 1454944

End: 1456233

Strand: Direct

Name: hisD [H]

Synonym: BCQ_1479

Alternate gene names: 222095139

Gene position: 1454944-1456233 (Clockwise)

Preceding gene: 222095138

Following gene: 222095140

Centisome position: 27.9

GC content: 37.98

Gene sequence:

>1290_bases
ATGGAGATCGTTTTTGAAGATTTTCAAAAGGCGTTATCGAAAATAAAATTGCTACGAGAAAACGCTAATATAATGGAAGA
AACTGTTCAAAGAAATGTAAGTGAAATCGTTCAAAATGTAAGGGAGAGTAGAGATGAGGCCTTATCTTTTTATACAAAAA
AGTTTGATGGTGTAAAGATGAAAGAGTTTCGTGTAAGTGAAGAAGAAATAAAACGAGCGAGTATGTTTGTAGAGAATTCA
TTTTTAGAAGCGTTACAAGAGGCGAAGAAAAACATTATTTCGTACCATGAAAAGCAAAAAAGACAATCGATGTTCGATTG
CGCGAGTAAAGGCATCATTAGAGGACAAATCATTCGGCCATTAGAGAATGTAGGCGTATATGTGCCAGGCGGAACTGCTT
CGTATCCTTCGTCAGTATTAATGAATGTATTGCCAGCAAAACTCGCTGGTGTGAAAAAGATTGTAATGGTAACACCGCCA
AGAGAAGGAGGAATTGATCCACATATTTTAGTTGCTGCAAGTCTTGCAGGAGTAGATGAAATTTATACGATAGGTGGTGC
GCAAGCAATTGCTGCTTTAGCATACGGGACGGAATCGATTCCGAAAGTGGATAAAATAGTTGGACCAGGAAATTTGTACG
TCGCTCTAGCGAAACGAGAAGTATATGGAATAGTAAATATTGATATGATTGCTGGACCGTCAGAAATTGTAGTTATTGCA
GATGAAACCGGCAATGCAAAATATATTGCTGCTGATTTATTATCACAAGCAGAACATGACGAGAGAGCGACAGCAATTTG
TATTACAACAAATATAGAGTTAGCAAAAGAAGTAGAAAAAGAGATAGAAAGGCAGTTAGAAACATTACCAAGAAGCGAAA
TTGCACGTGAATCAATAAAGAGAAATGGGGCCATTTTTATCGTTCCTTCTTTAGATGAGGCGCTAAATTTATCGAATGAA
GTTGCCCCGGAACATTTAGAGTTACATATAAAAGAACCGATGAATGCTCTAGCTTATGTGAAACATGCAGGATCTATCTT
TCTTGGACCATATGCACCAGAACCGCTCGGGGATTATTTAGCAGGACCGAATCACGTGTTACCGACAAGTGGAACGGCAA
GGTTTTTCTCACCGTTATCAGTCGATGATTTTGTGAAAAAATCAAGCTTTCTGTCTTATACAGAGGAAGCATTAAGAGAT
GTAAAACATCATATTGTAGAGCTTGCCAGTAAAGAAGGGTTACATGCGCATGCGAGAGCAATTCAAATAAGATTTGAGGA
GGAAGAATAA

Upstream 100 bases:

>100_bases
TTGTAAATAAGGCTGCATTAAAAACTAAAAAAGACGAAATATTCAGTATTATAAATATGATGGAGCAAGAAATTTTGTCA
GGAAAATAGGGGGACTTGTA

Downstream 100 bases:

>100_bases
TGCGTGAGTCTAGTCAAATACGTGAGACGACAGAGACAAAAATAAAATTAAGTTTACAGCTTGATGATGGGAAGAACGTT
TCTGTACGAACGGGAGTTGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEIVFEDFQKALSKIKLLRENANIMEETVQRNVSEIVQNVRESRDEALSFYTKKFDGVKMKEFRVSEEEIKRASMFVENS
FLEALQEAKKNIISYHEKQKRQSMFDCASKGIIRGQIIRPLENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
REGGIDPHILVAASLAGVDEIYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIKRNGAIFIVPSLDEALNLSNE
VAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRD
VKHHIVELASKEGLHAHARAIQIRFEEEE

Sequences:

>Translated_429_residues
MEIVFEDFQKALSKIKLLRENANIMEETVQRNVSEIVQNVRESRDEALSFYTKKFDGVKMKEFRVSEEEIKRASMFVENS
FLEALQEAKKNIISYHEKQKRQSMFDCASKGIIRGQIIRPLENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
REGGIDPHILVAASLAGVDEIYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIKRNGAIFIVPSLDEALNLSNE
VAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRD
VKHHIVELASKEGLHAHARAIQIRFEEEE
>Mature_429_residues
MEIVFEDFQKALSKIKLLRENANIMEETVQRNVSEIVQNVRESRDEALSFYTKKFDGVKMKEFRVSEEEIKRASMFVENS
FLEALQEAKKNIISYHEKQKRQSMFDCASKGIIRGQIIRPLENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
REGGIDPHILVAASLAGVDEIYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIKRNGAIFIVPSLDEALNLSNE
VAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRD
VKHHIVELASKEGLHAHARAIQIRFEEEE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=412, Percent_Identity=41.0194174757282, Blast_Score=311, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6319819, Length=413, Percent_Identity=39.4673123486683, Blast_Score=284, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47411; Mature: 47411

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVFEDFQKALSKIKLLRENANIMEETVQRNVSEIVQNVRESRDEALSFYTKKFDGVKM
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
KEFRVSEEEIKRASMFVENSFLEALQEAKKNIISYHEKQKRQSMFDCASKGIIRGQIIRP
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
LENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCHHH
IYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
HHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIK
ECCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RNGAIFIVPSLDEALNLSNEVAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYL
CCCCEEEEECCHHHHCCCCCCCCHHHEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRDVKHHIVELASKEGLHAHARA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IQIRFEEEE
EEEEEECCC
>Mature Secondary Structure
MEIVFEDFQKALSKIKLLRENANIMEETVQRNVSEIVQNVRESRDEALSFYTKKFDGVKM
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
KEFRVSEEEIKRASMFVENSFLEALQEAKKNIISYHEKQKRQSMFDCASKGIIRGQIIRP
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
LENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCHHH
IYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
HHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIK
ECCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RNGAIFIVPSLDEALNLSNEVAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYL
CCCCEEEEECCHHHHCCCCCCCCHHHEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRDVKHHIVELASKEGLHAHARA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IQIRFEEEE
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]