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The map label for this gene is hisG [H]

Identifier: 222095138

GI number: 222095138

Start: 1454297

End: 1454932

Strand: Direct

Name: hisG [H]

Synonym: BCQ_1478

Alternate gene names: 222095138

Gene position: 1454297-1454932 (Clockwise)

Preceding gene: 222095137

Following gene: 222095139

Centisome position: 27.89

GC content: 32.7

Gene sequence:

>636_bases
ATGCGTAACATTCAAATTGCGTTAACGAAAGGGAGATTAGAAAAACATGTGATTCCGCTCTTTGAGCAGATTGGAATTGA
TTGTTCAGAGCTCAAAAATAAAGGAAGAAAACTTGTCTTTCAAAGTAAAAATACGGATATCTCATTTATTTTAGTGAAAG
CAGTAGATGTTGCTACTTATGTAGAACATGGAGTAGCGGATATCGGAGTCGTTGGAAAAGATATTTTAATGGAAAACGAG
AAAGATATTTATGAAATGTTAGATTTAGGAGTAGGCGTGTGTAAGTTTTGTGTCGCTTCTATTCCTACTTATAATCCGAA
GAGCTACCGGAAGAAATGCATTGCGACGAAATATCCACATATTACTTCTAACTATTTTCATGATAAAGGAGAGGATGTAG
AAATTATTAAAATAGAAGGTTCTGTAGAAATTGCTCCTATTCTTGGATTGGCAGATGCGATTGTTGATATTGTTGAAACA
GGAAAAACATTACAAGAAAATGGACTCATTGTATTTGAGGAAATGTATTCTATATCTGCTCGAATGATTGTAAATAAGGC
TGCATTAAAAACTAAAAAAGACGAAATATTCAGTATTATAAATATGATGGAGCAAGAAATTTTGTCAGGAAAATAG

Upstream 100 bases:

>100_bases
GAAAAAATCAAATTGTAACGGTCGTTGAGGCAAAGAACGAATCATTAGTGGAATATGTATGGAAAGAGAAATGGGTCGTC
CAGAAAGAAGGAGAAACTTC

Downstream 100 bases:

>100_bases
GGGGACTTGTAATGGAGATCGTTTTTGAAGATTTTCAAAAGGCGTTATCGAAAATAAAATTGCTACGAGAAAACGCTAAT
ATAATGGAAGAAACTGTTCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVADIGVVGKDILMENE
KDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHDKGEDVEIIKIEGSVEIAPILGLADAIVDIVET
GKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK

Sequences:

>Translated_211_residues
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVADIGVVGKDILMENE
KDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHDKGEDVEIIKIEGSVEIAPILGLADAIVDIVET
GKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK
>Mature_211_residues
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVADIGVVGKDILMENE
KDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHDKGEDVEIIKIEGSVEIAPILGLADAIVDIVET
GKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=208, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=205, Percent_Identity=31.219512195122, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23586; Mature: 23586

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATY
CCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCEEEEEEHHHHHHHH
VEHGVADIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPH
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
ITSNYFHDKGEDVEIIKIEGSVEIAPILGLADAIVDIVETGKTLQENGLIVFEEMYSISA
CCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHCCEEEEHHHHHHHH
RMIVNKAALKTKKDEIFSIINMMEQEILSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATY
CCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCEEEEEEHHHHHHHH
VEHGVADIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPH
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
ITSNYFHDKGEDVEIIKIEGSVEIAPILGLADAIVDIVETGKTLQENGLIVFEEMYSISA
CCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHCCEEEEHHHHHHHH
RMIVNKAALKTKKDEIFSIINMMEQEILSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA