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The map label for this gene is trpA [H]

Identifier: 222094967

GI number: 222094967

Start: 1294496

End: 1295257

Strand: Direct

Name: trpA [H]

Synonym: BCQ_1305

Alternate gene names: 222094967

Gene position: 1294496-1295257 (Clockwise)

Preceding gene: 222094966

Following gene: 222094968

Centisome position: 24.83

GC content: 39.76

Gene sequence:

>762_bases
ATGAAAGCAGCATTTGAAAATGGCAAGAAAGCATTTATTCCGTACGTAATGGGCGGAGATGGTGGCCTTGAAAAATTAAA
AGAAAGAATTCGTTTTCTTGATGAAGCAGGAGCAAGCATCGTTGAAATTGGTATCCCGTTTTCAGATCCAGTCGCAGATG
GCCCAACGATTCAAAGAGCAGGGAAACGAGCGCTAGATGGCGGTGTAACATTAAAGGGCATTTTTCAAGCGTTAGCAGAA
GTAAGAAAAGAAGTACAAATTCCTTTTGTACTCATGACATACTTAAATCCAGTACTTGCATTCGGAAAAGAACACTTCAT
TGAGAGATGCTTAGAAGCAGGTGTGGACGGTATTATCGTTCCAGACTTACCGTATGAAGAACAAGATATTATTGCACCGC
TTCTCCGAACTGCAAATATCGCTTTAATCCCACTCGTTACCGTTACGAGCCCAATTGAGCGAATCGAGAAAATTACGAGT
GAATCAGAAGGGTTCGTCTACGCTGTTACAGTAGCAGGCGTAACAGGCGTACGTCAAAACTTTAAAGAGGAGATTCATAG
TTACTTAGAAAAAGTAAAATCACATACGCATTTACCGGTAGTGGCAGGGTTCGGTATTTCAACAAAGGAACATGTAGAAG
AAATGATTACAATATGTGACGGGGTTGTCGTTGGAAGTAAAATTATTGAACTGTTAGAAAATGAAAAACGAGAAGAAATA
TGTGAATTCATACAGGCAACAAAACAAAAAGAAGAGGCATAA

Upstream 100 bases:

>100_bases
AGACGAAGGGCTTGTCATTTGTTTATCTGGCCGCGGTGATAAAGATGTAGAGAGTATAAAACGTTATATGGAAGAGGTGT
AAACAATGGGAGTAGAAAAA

Downstream 100 bases:

>100_bases
GTCTCTTCTTTTTGTTTTCCACAATAAATGTTAAAATATACAGAAAATACATATAATTTAGAGGGTGAGAAAGCATGCTA
AGACGGAAACTATTATATCT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDGGVTLKGIFQALAE
VRKEVQIPFVLMTYLNPVLAFGKEHFIERCLEAGVDGIIVPDLPYEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITS
ESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMITICDGVVVGSKIIELLENEKREEI
CEFIQATKQKEEA

Sequences:

>Translated_253_residues
MKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDGGVTLKGIFQALAE
VRKEVQIPFVLMTYLNPVLAFGKEHFIERCLEAGVDGIIVPDLPYEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITS
ESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMITICDGVVVGSKIIELLENEKREEI
CEFIQATKQKEEA
>Mature_253_residues
MKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDGGVTLKGIFQALAE
VRKEVQIPFVLMTYLNPVLAFGKEHFIERCLEAGVDGIIVPDLPYEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITS
ESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMITICDGVVVGSKIIELLENEKREEI
CEFIQATKQKEEA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=238, Percent_Identity=36.9747899159664, Blast_Score=136, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321412, Length=256, Percent_Identity=35.15625, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27778; Mature: 27778

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRA
CCCCHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHH
GKRALDGGVTLKGIFQALAEVRKEVQIPFVLMTYLNPVLAFGKEHFIERCLEAGVDGIIV
HHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PDLPYEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQN
CCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHH
FKEEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMITICDGVVVGSKIIELLENEKREEI
HHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
CEFIQATKQKEEA
HHHHHHHHHHCCC
>Mature Secondary Structure
MKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRA
CCCCHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHH
GKRALDGGVTLKGIFQALAEVRKEVQIPFVLMTYLNPVLAFGKEHFIERCLEAGVDGIIV
HHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PDLPYEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQN
CCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHH
FKEEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMITICDGVVVGSKIIELLENEKREEI
HHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
CEFIQATKQKEEA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA