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The map label for this gene is clpB [H]

Identifier: 222094897

GI number: 222094897

Start: 1227637

End: 1230237

Strand: Direct

Name: clpB [H]

Synonym: BCQ_1235

Alternate gene names: 222094897

Gene position: 1227637-1230237 (Clockwise)

Preceding gene: 222094892

Following gene: 222094899

Centisome position: 23.54

GC content: 38.6

Gene sequence:

>2601_bases
ATGGACTTAAATCAAATGACAACAAAAACACAAGAGGCGATTATGAGTGCCCAATCTTTAGCGGTATCTCATCACCATCA
AGAAGTAGATACTGTTCATCTCTTGTTTACATTATTAGAAGAGCAAGATGGGTTAGCAGTACGTATTTTTCAAAAAATGA
ACGTCGATATAGAAGCATTAAAACAAGGCGCCGAAAATTTAATTAAGAAAAAGCCTTCCGTAACGGGGAGCGGTGCAGAA
GCAGGTAAATTATATATAACAGGTGCTCTGCAACAATTACTTGTAAGAGCAGGAAAAGAAGCAGAGAAATTGCAAGATGA
CTACATTTCAATTGAACATGTATTGCTTGCTTTTACTGAAGAAAAAGGCGATATAAACCAATTATTTACAAGATTTCATA
TTACGAAAGATAACTTATTACAGTCTTTAATGACAGTTCGGGGGAATCAAAGAGTGACTAGTCAAAATCCAGAAGCAACT
TATGAAGCGTTAGAAAAATATGGTCGTGATTTAGTTGCGGAAGTAAGAGCGGGGAAAATTGACCCTGTTATCGGCCGCGA
TAGTGAAATTCGCCGCGTAATCCGCATTCTTTCACGTAAAACGAAAAACAACCCAGTTTTAATTGGTGAACCAGGTGTTG
GTAAAACAGCAATTGTTGAAGGGTTAGCACAGCGTATTGTGAAAAAGGATGTACCTGAAGGATTAAAAGATAGAACAATC
TTTGCATTAGATATGAGTGCGCTTGTAGCTGGAGCGAAATTCCGTGGTGAATTTGAAGAGCGACTGCAAGCTGTATTAAA
TGAAATTAAAAAGAGTGAAGGACGCATTTTATTATTCATTGATGAACTTCATACAATCGTCGGCGCTGGTAAAACAGAAG
GCGCAATGGATGCAGGAAATATGTTAAAACCGATGCTTGCGCGTGGTGAACTGCATTGTATCGGGGCGACGACGTTAGAT
GAATATCGTAAATATATTGAGAAAGATCCAGCGCTAGAAAGACGTTTCCAACAAGTATTAGCAGAAGAACCAACTGTTGA
AGATACAATTTCCATTTTACGTGGTTTAAAAGAGCGCTTTGAAATTTATCATGGTGTAAATATTCATGACCGCGCGATTG
TAGCAGCATCAGTTTTATCAGATCGATATATTTCGGATCGTTTCTTACCGGATAAAGCAATTGATCTTGTTGACGAAGCG
TGCGCAACAATTCGTACAGAAATTGATTCTATGCCAACAGAATTAGATGAAGTAACGCGTCGCATTATGCAGCTGGAAAT
TGAAGAAGCAGCTCTTGGAAAAGAGAAAGACTTTGGTAGCCAAGAACGTCTAAAAACATTGCAACGTGAATTATCGGATT
TAAAAGAAGTGGCAAGTGGCATGAGAGCCAAATGGGAGAAAGAAAAAGAAGATATTCACAAAGTTCGTGACTTACGTGAA
CATTTAGAGCGTCTGCGCCGTGAATTAGAAGAAGCAGAAGGTAATTACGACTTAAATAGAGCAGCGGAACTTCGCCACGG
AAAAATTCCTGCAATTGAAAAAGAGTTAAAAGAAGCAGAAGAAATGGGCGCGAATAATAAACAAGAAAATCGTTTATTAC
GTGAGGAAGTAAGTGAAGAAGAGATTGCTGATATTGTTTCACGTTGGACTGGTATTCCTGTTGCAAAACTCGTTGAAGGT
GAACGCGAGAAATTACTACGTTTAGAGCAAATTTTATCAGAGCGTGTCATCGGACAAGAAGAAGCAGTAAGCTTAGTATC
AGACGCAGTTCTTCGTGCACGCGCAGGTATTAAAGACCCGAACCGTCCGATTGGTTCCTTCATTTTCTTAGGACCTACTG
GTGTTGGTAAAACAGAACTTGCAAAAACGTTAGCGCAGTCATTATTTGATAGTGAAGAACAAATGATTCGTATTGATATG
TCTGAGTATATGGAGAAACACGCTGTGTCACGCTTAATTGGTGCGCCTCCTGGATATGTTGGATATGAAGAGGGCGGTCA
ATTAACAGAAGCGGTAAGACGTAAACCGTATTCGGTTATTTTATTAGACGAAATCGAAAAAGCACATCCAGAAGTATTCA
ACATTTTATTACAAATGTTAGATGACGGTCGCATTACAGATTCGCAAGGACGTACAGTAGACTTTAAAAACACGGTTATT
ATTATGACTTCAAATATTGGATCTGCTCATTTATTAGATGGACTAGGAGAAGATGGCTCCATTAAAGAAGAATCAAGAGA
ACTTGTCATGGGGCAATTAAGAGGACATTTCCGACCAGAGTTTTTAAATCGTGTCGACGAAATTATTTTATTCAAACCTC
TTACAACGAATGAAATTAAAGGTATTGTTGATAAAATTGTAAAAGAATTACAAGGCCGTTTAGCTGACCGTCATATTACG
GTACAATTAACAGACGCAGCGAAAGAGTTTGTTGTCGAAGTTGGCTTCGATCCGATGTACGGAGCTCGTCCGTTAAAACG
ATATGTACAGCGTCAAGTTGAGACGAAATTAGCGAGAGAATTAATTGCAGGAACGATTACTGATAACAGTCACGTAGTTG
TTGATGTAGAAAATAACGAATTAGTCGTTCATGTGAAGTAA

Upstream 100 bases:

>100_bases
AGTTTGAAAATACATAAGCAAAATTATTGTATAAAAAAGTCAGTTGGCGTATAATCAAATCAAAGGTCAAAGAAAGTCAA
ACATTTGGAGGACTGTAAAG

Downstream 100 bases:

>100_bases
AACAAAAAAGAGTTCGGATAAAATCCGGACTCTTTTTTTAGTGTTGTTCTACTGGCTCGTTTGGAATTGCAGCTGCAATT
GCTAGTACGAATACTGCAAG

Product: ATP-dependent clp protease, ATP-binding subunit clpb

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 866; Mature: 866

Protein sequence:

>866_residues
MDLNQMTTKTQEAIMSAQSLAVSHHHQEVDTVHLLFTLLEEQDGLAVRIFQKMNVDIEALKQGAENLIKKKPSVTGSGAE
AGKLYITGALQQLLVRAGKEAEKLQDDYISIEHVLLAFTEEKGDINQLFTRFHITKDNLLQSLMTVRGNQRVTSQNPEAT
YEALEKYGRDLVAEVRAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPEGLKDRTI
FALDMSALVAGAKFRGEFEERLQAVLNEIKKSEGRILLFIDELHTIVGAGKTEGAMDAGNMLKPMLARGELHCIGATTLD
EYRKYIEKDPALERRFQQVLAEEPTVEDTISILRGLKERFEIYHGVNIHDRAIVAASVLSDRYISDRFLPDKAIDLVDEA
CATIRTEIDSMPTELDEVTRRIMQLEIEEAALGKEKDFGSQERLKTLQRELSDLKEVASGMRAKWEKEKEDIHKVRDLRE
HLERLRRELEEAEGNYDLNRAAELRHGKIPAIEKELKEAEEMGANNKQENRLLREEVSEEEIADIVSRWTGIPVAKLVEG
EREKLLRLEQILSERVIGQEEAVSLVSDAVLRARAGIKDPNRPIGSFIFLGPTGVGKTELAKTLAQSLFDSEEQMIRIDM
SEYMEKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVILLDEIEKAHPEVFNILLQMLDDGRITDSQGRTVDFKNTVI
IMTSNIGSAHLLDGLGEDGSIKEESRELVMGQLRGHFRPEFLNRVDEIILFKPLTTNEIKGIVDKIVKELQGRLADRHIT
VQLTDAAKEFVVEVGFDPMYGARPLKRYVQRQVETKLARELIAGTITDNSHVVVDVENNELVVHVK

Sequences:

>Translated_866_residues
MDLNQMTTKTQEAIMSAQSLAVSHHHQEVDTVHLLFTLLEEQDGLAVRIFQKMNVDIEALKQGAENLIKKKPSVTGSGAE
AGKLYITGALQQLLVRAGKEAEKLQDDYISIEHVLLAFTEEKGDINQLFTRFHITKDNLLQSLMTVRGNQRVTSQNPEAT
YEALEKYGRDLVAEVRAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPEGLKDRTI
FALDMSALVAGAKFRGEFEERLQAVLNEIKKSEGRILLFIDELHTIVGAGKTEGAMDAGNMLKPMLARGELHCIGATTLD
EYRKYIEKDPALERRFQQVLAEEPTVEDTISILRGLKERFEIYHGVNIHDRAIVAASVLSDRYISDRFLPDKAIDLVDEA
CATIRTEIDSMPTELDEVTRRIMQLEIEEAALGKEKDFGSQERLKTLQRELSDLKEVASGMRAKWEKEKEDIHKVRDLRE
HLERLRRELEEAEGNYDLNRAAELRHGKIPAIEKELKEAEEMGANNKQENRLLREEVSEEEIADIVSRWTGIPVAKLVEG
EREKLLRLEQILSERVIGQEEAVSLVSDAVLRARAGIKDPNRPIGSFIFLGPTGVGKTELAKTLAQSLFDSEEQMIRIDM
SEYMEKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVILLDEIEKAHPEVFNILLQMLDDGRITDSQGRTVDFKNTVI
IMTSNIGSAHLLDGLGEDGSIKEESRELVMGQLRGHFRPEFLNRVDEIILFKPLTTNEIKGIVDKIVKELQGRLADRHIT
VQLTDAAKEFVVEVGFDPMYGARPLKRYVQRQVETKLARELIAGTITDNSHVVVDVENNELVVHVK
>Mature_866_residues
MDLNQMTTKTQEAIMSAQSLAVSHHHQEVDTVHLLFTLLEEQDGLAVRIFQKMNVDIEALKQGAENLIKKKPSVTGSGAE
AGKLYITGALQQLLVRAGKEAEKLQDDYISIEHVLLAFTEEKGDINQLFTRFHITKDNLLQSLMTVRGNQRVTSQNPEAT
YEALEKYGRDLVAEVRAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPEGLKDRTI
FALDMSALVAGAKFRGEFEERLQAVLNEIKKSEGRILLFIDELHTIVGAGKTEGAMDAGNMLKPMLARGELHCIGATTLD
EYRKYIEKDPALERRFQQVLAEEPTVEDTISILRGLKERFEIYHGVNIHDRAIVAASVLSDRYISDRFLPDKAIDLVDEA
CATIRTEIDSMPTELDEVTRRIMQLEIEEAALGKEKDFGSQERLKTLQRELSDLKEVASGMRAKWEKEKEDIHKVRDLRE
HLERLRRELEEAEGNYDLNRAAELRHGKIPAIEKELKEAEEMGANNKQENRLLREEVSEEEIADIVSRWTGIPVAKLVEG
EREKLLRLEQILSERVIGQEEAVSLVSDAVLRARAGIKDPNRPIGSFIFLGPTGVGKTELAKTLAQSLFDSEEQMIRIDM
SEYMEKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVILLDEIEKAHPEVFNILLQMLDDGRITDSQGRTVDFKNTVI
IMTSNIGSAHLLDGLGEDGSIKEESRELVMGQLRGHFRPEFLNRVDEIILFKPLTTNEIKGIVDKIVKELQGRLADRHIT
VQLTDAAKEFVVEVGFDPMYGARPLKRYVQRQVETKLARELIAGTITDNSHVVVDVENNELVVHVK

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=311, Percent_Identity=39.871382636656, Blast_Score=215, Evalue=2e-55,
Organism=Escherichia coli, GI1788943, Length=862, Percent_Identity=54.1763341067285, Blast_Score=929, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=330, Percent_Identity=43.030303030303, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320464, Length=712, Percent_Identity=52.1067415730337, Blast_Score=746, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=866, Percent_Identity=42.0323325635104, Blast_Score=673, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 97499; Mature: 97499

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNQMTTKTQEAIMSAQSLAVSHHHQEVDTVHLLFTLLEEQDGLAVRIFQKMNVDIEAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHH
KQGAENLIKKKPSVTGSGAEAGKLYITGALQQLLVRAGKEAEKLQDDYISIEHVLLAFTE
HHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
EKGDINQLFTRFHITKDNLLQSLMTVRGNQRVTSQNPEATYEALEKYGRDLVAEVRAGKI
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPEGLKDRTI
CCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
FALDMSALVAGAKFRGEFEERLQAVLNEIKKSEGRILLFIDELHTIVGAGKTEGAMDAGN
EEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCHH
MLKPMLARGELHCIGATTLDEYRKYIEKDPALERRFQQVLAEEPTVEDTISILRGLKERF
HHHHHHHCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EIYHGVNIHDRAIVAASVLSDRYISDRFLPDKAIDLVDEACATIRTEIDSMPTELDEVTR
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RIMQLEIEEAALGKEKDFGSQERLKTLQRELSDLKEVASGMRAKWEKEKEDIHKVRDLRE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLERLRRELEEAEGNYDLNRAAELRHGKIPAIEKELKEAEEMGANNKQENRLLREEVSEE
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHH
EIADIVSRWTGIPVAKLVEGEREKLLRLEQILSERVIGQEEAVSLVSDAVLRARAGIKDP
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
NRPIGSFIFLGPTGVGKTELAKTLAQSLFDSEEQMIRIDMSEYMEKHAVSRLIGAPPGYV
CCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHEEEECHHHHHHHHHHHHHHCCCCCCC
GYEEGGQLTEAVRRKPYSVILLDEIEKAHPEVFNILLQMLDDGRITDSQGRTVDFKNTVI
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCEEEECCEEE
IMTSNIGSAHLLDGLGEDGSIKEESRELVMGQLRGHFRPEFLNRVDEIILFKPLTTNEIK
EEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCHHHHH
GIVDKIVKELQGRLADRHITVQLTDAAKEFVVEVGFDPMYGARPLKRYVQRQVETKLARE
HHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LIAGTITDNSHVVVDVENNELVVHVK
HHHHEECCCCEEEEEECCCEEEEEEC
>Mature Secondary Structure
MDLNQMTTKTQEAIMSAQSLAVSHHHQEVDTVHLLFTLLEEQDGLAVRIFQKMNVDIEAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHH
KQGAENLIKKKPSVTGSGAEAGKLYITGALQQLLVRAGKEAEKLQDDYISIEHVLLAFTE
HHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
EKGDINQLFTRFHITKDNLLQSLMTVRGNQRVTSQNPEATYEALEKYGRDLVAEVRAGKI
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPEGLKDRTI
CCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
FALDMSALVAGAKFRGEFEERLQAVLNEIKKSEGRILLFIDELHTIVGAGKTEGAMDAGN
EEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCHH
MLKPMLARGELHCIGATTLDEYRKYIEKDPALERRFQQVLAEEPTVEDTISILRGLKERF
HHHHHHHCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EIYHGVNIHDRAIVAASVLSDRYISDRFLPDKAIDLVDEACATIRTEIDSMPTELDEVTR
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RIMQLEIEEAALGKEKDFGSQERLKTLQRELSDLKEVASGMRAKWEKEKEDIHKVRDLRE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLERLRRELEEAEGNYDLNRAAELRHGKIPAIEKELKEAEEMGANNKQENRLLREEVSEE
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHH
EIADIVSRWTGIPVAKLVEGEREKLLRLEQILSERVIGQEEAVSLVSDAVLRARAGIKDP
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
NRPIGSFIFLGPTGVGKTELAKTLAQSLFDSEEQMIRIDMSEYMEKHAVSRLIGAPPGYV
CCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHEEEECHHHHHHHHHHHHHHCCCCCCC
GYEEGGQLTEAVRRKPYSVILLDEIEKAHPEVFNILLQMLDDGRITDSQGRTVDFKNTVI
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCEEEECCEEE
IMTSNIGSAHLLDGLGEDGSIKEESRELVMGQLRGHFRPEFLNRVDEIILFKPLTTNEIK
EEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCHHHHH
GIVDKIVKELQGRLADRHITVQLTDAAKEFVVEVGFDPMYGARPLKRYVQRQVETKLARE
HHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LIAGTITDNSHVVVDVENNELVVHVK
HHHHEECCCCEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]