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The map label for this gene is hemH-2 [H]

Identifier: 222094877

GI number: 222094877

Start: 1204325

End: 1205284

Strand: Direct

Name: hemH-2 [H]

Synonym: BCQ_1215

Alternate gene names: 222094877

Gene position: 1204325-1205284 (Clockwise)

Preceding gene: 222094876

Following gene: 222094878

Centisome position: 23.1

GC content: 36.25

Gene sequence:

>960_bases
ATGAAAAAGAAAAAAATAGGTTTACTCGTAATGGCGTATGGAACGCCGGATTCATTAGATGAAGTAGAGGCATATTATAC
ACATATTCGTCATGGGCGTAAGCCATCAGAAGAAGCACTCCAAGATTTAATTGGACGTTATAAAGCGATTGGTGGAATTT
CACCGCTTGCAAAAATTACGAAAGAGCAAGCGCATAAATTAACAGACTTAATGAATAATATGTTTACAGAGTATGAATTT
AATTGTTACTTAGGCTTAAAACATACTGCTCCGTTTATAGAAGATGCAGTAGAAGAGATGAAGCGCGATGGAATTGAGCA
AGCAATTAGTATCGTATTAGCACCGCATTATTCTACCTTTAGCATTAAGGCATATAACGAGCGTGCAATTCGTCTCTCGG
AGGAAATAGGTGGTCCTGTTATTGAGCCGATTGACCAATGGTACGATGAACCGAAGTTTATTTCGTATTGGGCAGATCAA
ATAAAAGAAACATTTACAAAAATTGAAGATAAAGAGAAAGCAGTTGTAATTTTTTCTGCGCATAGTTTACCAGAGAAAAT
TATTGCAGCAGGTGATCCTTATGTGGAGCAATTGCAGCATACAGCGGATTTAATCGCAGCAGCTGCAAACATCCAAAACT
ATACAATTGGTTGGCAAAGTGCCGGAAATACACCTGATCCATGGATTGGACCAGATGTGCAAGATTTAACGAGAGATTTA
TTTGAAGAGCATAGATATAAATCTTTCATATATTGCCCAGTCGGTTTTGTGGCAGAGCATTTAGAAGTTTTATATGACAA
CGATTACGAGTGTAAAGTTGTGACGGATGAATTAAATGCTGCGTATTTTAGACCAAATATGCCGAATGCACAATCTACAT
TTATTGATTGTTTAGCTACAATTGTTTCCAGAAAAGTGAAAGAAATAGTTGACAAAGAACTAATTTTGAACAATAATTAA

Upstream 100 bases:

>100_bases
TTTAGAATAATTATCTTTACGTACTTATTATTAGTTGTTATAATTGGAAACAAATGTTCTTGAAAAAGATTCTCATTTAT
AAAATTGAGGTGTTATATAG

Downstream 100 bases:

>100_bases
TTTATAATAATTTTAAATAAATAATAATTACTATGAAAGAAAGAGGAGGATCCCCCTAGATGAATCCAAATAATCGCTTA
ACAACAAACCAAGGTGCTCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDLMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ
IKETFTKIEDKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEHRYKSFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKVKEIVDKELILNNN

Sequences:

>Translated_319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDLMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ
IKETFTKIEDKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEHRYKSFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKVKEIVDKELILNNN
>Mature_319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDLMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ
IKETFTKIEDKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEHRYKSFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKVKEIVDKELILNNN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=341, Percent_Identity=28.1524926686217, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI60499021, Length=340, Percent_Identity=28.2352941176471, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1786681, Length=189, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324750, Length=323, Percent_Identity=23.5294117647059, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=28.3987915407855, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=27.6264591439689, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=33.1360946745562, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36335; Mature: 36335

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDLMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
SIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQIKETFTKIEDKEKAVVIFSA
EEEECCCHHEEEHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
HSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHH
FEEHRYKSFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLAT
HHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSRKVKEIVDKELILNNN
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDLMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
SIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQIKETFTKIEDKEKAVVIFSA
EEEECCCHHEEEHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
HSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHH
FEEHRYKSFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLAT
HHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSRKVKEIVDKELILNNN
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]