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The map label for this gene is malR [H]

Identifier: 222094329

GI number: 222094329

Start: 633953

End: 634627

Strand: Direct

Name: malR [H]

Synonym: BCQ_0643

Alternate gene names: 222094329

Gene position: 633953-634627 (Clockwise)

Preceding gene: 222094328

Following gene: 222094330

Centisome position: 12.16

GC content: 32.59

Gene sequence:

>675_bases
ATGGTAGCGATGTTAAATACGCATTATTTAGAGCAAGTAGGAGGGTTTGAACTTGTTCAAGCAGTGAATTCGGTAAAATC
GGCGATAGAAGTATTAGAGGAATCACGAGTAGATTTAGTATTACTTGATATTTTTATGCCTGAAGAGACTGGATTTGAGC
TTTTAATGTATATTCGGAACCAAGAAAAAGAAATCGATATTATGATGATTTCAGCTGTACATGATATGGGGAGTATTAAA
AAAGCATTACAATATGGCGTAGTAGATTATTTAATTAAACCATTTACATTTGAACGATTTAAAGAAGCATTAACTATATA
TCGAGAAAAACTTACTTTCATGAAAGAACAACAAAAAATTAGTCAATCGGAATTAGATTCGTTAATTTTGCAAAAAGAAA
AAAGAGAACCTACTGTCATGAAAGAGCTTCCGAAAGGATTAACGAAGCAAACGATGCAATTAATTTGGAAGAAGATCGAG
TCGTTGAATGGACGAGCGTTTACAACAGATGAAATGGCGCAATTAGTTGGTGTTTCAAGAGTTTCTATTCGAAAGTATGT
AATGTTTTTGACAGAAATTGGAGTGTTAGAAAACGAAATGGTGTATCAACATGTAGGGAGACCGGTGAGTAAATTAAGAT
GTATTGACCAAAATAAAATAGAGTTTTACGTATAA

Upstream 100 bases:

>100_bases
ATTCATTAGTAGGAAAGGGAACAACGATAACAATTGAAATACCTAAAGGTAGGGATGAGAGGCAAATATGATTAAAGTTT
TAATTGTAGAAGATGACCCG

Downstream 100 bases:

>100_bases
GCGACTTATTATAAGTCGCTTATACTTTTTTTAATTACAAAATCAATTACAAAACTTACAAAAACTATTTTTACTATTGA
AAGCGTTTTAATATTGTTAT

Product: response regulator

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEESRVDLVLLDIFMPEETGFELLMYIRNQEKEIDIMMISAVHDMGSIK
KALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKISQSELDSLILQKEKREPTVMKELPKGLTKQTMQLIWKKIE
SLNGRAFTTDEMAQLVGVSRVSIRKYVMFLTEIGVLENEMVYQHVGRPVSKLRCIDQNKIEFYV

Sequences:

>Translated_224_residues
MVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEESRVDLVLLDIFMPEETGFELLMYIRNQEKEIDIMMISAVHDMGSIK
KALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKISQSELDSLILQKEKREPTVMKELPKGLTKQTMQLIWKKIE
SLNGRAFTTDEMAQLVGVSRVSIRKYVMFLTEIGVLENEMVYQHVGRPVSKLRCIDQNKIEFYV
>Mature_224_residues
MVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEESRVDLVLLDIFMPEETGFELLMYIRNQEKEIDIMMISAVHDMGSIK
KALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKISQSELDSLILQKEKREPTVMKELPKGLTKQTMQLIWKKIE
SLNGRAFTTDEMAQLVGVSRVSIRKYVMFLTEIGVLENEMVYQHVGRPVSKLRCIDQNKIEFYV

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=215, Percent_Identity=40.4651162790698, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1786838, Length=207, Percent_Identity=27.536231884058, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26072; Mature: 26072

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEESRVDLVLLDIFMPEETGFELLMYIRN
CEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHC
QEKEIDIMMISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SQSELDSLILQKEKREPTVMKELPKGLTKQTMQLIWKKIESLNGRAFTTDEMAQLVGVSR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHH
VSIRKYVMFLTEIGVLENEMVYQHVGRPVSKLRCIDQNKIEFYV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEESRVDLVLLDIFMPEETGFELLMYIRN
CEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHC
QEKEIDIMMISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SQSELDSLILQKEKREPTVMKELPKGLTKQTMQLIWKKIESLNGRAFTTDEMAQLVGVSR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHH
VSIRKYVMFLTEIGVLENEMVYQHVGRPVSKLRCIDQNKIEFYV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]