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The map label for this gene is galE [H]

Identifier: 222094242

GI number: 222094242

Start: 532717

End: 533682

Strand: Direct

Name: galE [H]

Synonym: BCQ_0535

Alternate gene names: 222094242

Gene position: 532717-533682 (Clockwise)

Preceding gene: 222094241

Following gene: 222094243

Centisome position: 10.22

GC content: 34.99

Gene sequence:

>966_bases
ATGAGTAAGAAATGTTTAATCACAGGTGGAGCAGGATTTATTGGATCGCATTTAGCTGAAGAGCTGGTGAAAAGAGGTTA
TGATGTCACTATCGTTGATAACTTCTATAAAGGGAAAAATAAATATCATAATGAGTTAATGAAAGAAATTCGGGTTATTC
CAATAAGTGTTTTAGATAAAAATTCTATTTATGAATTAGTAAATCAACATGATGTAGTGTTTCATTTAGCAGCAATTTTA
GGTGTGAAAACGACAATGGAAAAGAGTATAGAGCTTATTGAAACGAATTTTGATGGAACGAGAAACATTTTACAAGCAGC
GCTAAAAGGAAAGAAGAAAGTAGTTTTTGCGTCTACTTCAGAAGTATATGGTAAGGCAAAGCCGCCCTTTTCTGAAGAAG
GAGATCGATTATACGGTGCAACCTCTAAAATACGTTGGAGTTATGCAATTTGTAAAACGTTAGAAGAAACATTATGTTTA
GGATACGCTTTAGAAGGTTTACCTGTAACGATTGTTCGTTATTTTAATATTTATGGTCCAAGAGCGAAAGATGGTCCGTA
TGCAGGGGTAATCCCACGATTTATCCGCGCAGCACTGCAAGGAGAAGACATTCTCGTATATGGAGATGGAAAGCAGACAC
GTTGTTTTACGTATGTAAGTGATGCGGTAGAGGCAACGATTCGAGCAATGGATGAGAAGGTAAATGGTGAGATTATTAAT
ATAGGTTCTGAGAATGAAAAGAGTATAAAAGAAGTAGCAGCAGTAATAAAAAAATTAACGAATTCTTCTTCAAAAATTGT
TCAAGTTCCTTTCGAAGAGGTATATCCACATGGCTTTGAAGAAATTCCAAATAGAAGACCAGATGTAACGAAATTAAGAG
AACTTGTTCAATTTCAAGCAAAAGTAACGTGGGAACAAGGGTTGAAAGAAACTATTAAATGGTTTCGTGAAGAAAACAAT
GGCTAA

Upstream 100 bases:

>100_bases
GTATTTTAATTTTAACAGACCACTCTAATATCGATTGGAAGGTTTTTAAAGGGATAAAGCAAGTCGTAGATACACGTGGA
ATTATAAAGAAGGTGAGTGT

Downstream 100 bases:

>100_bases
GTCACTATCGATTATTATACCTGTATGTAATGAAGTGGATACGATTTCAGACGTTATTCAATCGGCAAAAGGATTAAATC
CAGTAGAGATTATTGTAGTA

Product: udp-glucose 4-epimerase (nad-dependent epimerase)

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSKKCLITGGAGFIGSHLAEELVKRGYDVTIVDNFYKGKNKYHNELMKEIRVIPISVLDKNSIYELVNQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTSEVYGKAKPPFSEEGDRLYGATSKIRWSYAICKTLEETLCL
GYALEGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
IGSENEKSIKEVAAVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLRELVQFQAKVTWEQGLKETIKWFREENN
G

Sequences:

>Translated_321_residues
MSKKCLITGGAGFIGSHLAEELVKRGYDVTIVDNFYKGKNKYHNELMKEIRVIPISVLDKNSIYELVNQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTSEVYGKAKPPFSEEGDRLYGATSKIRWSYAICKTLEETLCL
GYALEGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
IGSENEKSIKEVAAVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLRELVQFQAKVTWEQGLKETIKWFREENN
G
>Mature_320_residues
SKKCLITGGAGFIGSHLAEELVKRGYDVTIVDNFYKGKNKYHNELMKEIRVIPISVLDKNSIYELVNQHDVVFHLAAILG
VKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTSEVYGKAKPPFSEEGDRLYGATSKIRWSYAICKTLEETLCLG
YALEGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIINI
GSENEKSIKEVAAVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLRELVQFQAKVTWEQGLKETIKWFREENNG

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=321, Percent_Identity=34.8909657320872, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI7657641, Length=330, Percent_Identity=29.6969696969697, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI56237023, Length=290, Percent_Identity=25.1724137931034, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI56118217, Length=290, Percent_Identity=25.1724137931034, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI189083684, Length=290, Percent_Identity=25.1724137931034, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI193211614, Length=240, Percent_Identity=25.4166666666667, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI8393516, Length=240, Percent_Identity=25.4166666666667, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788589, Length=334, Percent_Identity=28.7425149700599, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788353, Length=341, Percent_Identity=29.3255131964809, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994969, Length=353, Percent_Identity=29.4617563739377, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788365, Length=342, Percent_Identity=28.0701754385965, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1786974, Length=342, Percent_Identity=23.0994152046784, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790049, Length=330, Percent_Identity=23.6363636363636, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=322, Percent_Identity=33.2298136645963, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17568069, Length=334, Percent_Identity=31.1377245508982, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982035, Length=290, Percent_Identity=27.2413793103448, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=292, Percent_Identity=26.3698630136986, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=341, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=356, Percent_Identity=25.2808988764045, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=37.888198757764, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19923002, Length=260, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 36112; Mature: 35981

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKCLITGGAGFIGSHLAEELVKRGYDVTIVDNFYKGKNKYHNELMKEIRVIPISVLDK
CCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHHCCEEEEECC
NSIYELVNQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECH
EVYGKAKPPFSEEGDRLYGATSKIRWSYAICKTLEETLCLGYALEGLPVTIVRYFNIYGP
HHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
RAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
IGSENEKSIKEVAAVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLRELVQFQA
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHCCCCCCCHHHHHHHHHHHH
KVTWEQGLKETIKWFREENNG
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKKCLITGGAGFIGSHLAEELVKRGYDVTIVDNFYKGKNKYHNELMKEIRVIPISVLDK
CCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHHCCEEEEECC
NSIYELVNQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECH
EVYGKAKPPFSEEGDRLYGATSKIRWSYAICKTLEETLCLGYALEGLPVTIVRYFNIYGP
HHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
RAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
IGSENEKSIKEVAAVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLRELVQFQA
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHCCCCCCCHHHHHHHHHHHH
KVTWEQGLKETIKWFREENNG
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA