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The map label for this gene is capL [H]

Identifier: 222094241

GI number: 222094241

Start: 531476

End: 532720

Strand: Direct

Name: capL [H]

Synonym: BCQ_0534

Alternate gene names: 222094241

Gene position: 531476-532720 (Clockwise)

Preceding gene: 222094240

Following gene: 222094242

Centisome position: 10.19

GC content: 35.02

Gene sequence:

>1245_bases
ATGAATGTTAGTAATACAGTTGCCATTATCGGATTAGGATATGTTGGTCTTCCTTTGGCAGTTCATTTTGCAGAGAGAGG
ACATACAGTGCTTGGATTAGATAAAGATGCTAGAAAAATAGAATCAATTATACAGGGAGAAAGTTATATTCCAGATGTTT
CTTCTAAATCGTTACAAAGTTTATTGACTAGAAAAAAATTAATAGTCAATACACCGGATCAAGGTGTTGCTGATTTTCAA
AATAGTGATTACGTTATTGTCACTGTCCCAACTCCAATTAATGAACAAAGAGAACCAGACTTAAGTGCCCTCATTTCAGC
TTCGCATTATATACAACAACACCTTCAAAAAGGACAAACCTTCATTTTCGAAAGTTCCACATATCCAGGTACGCTCGAGG
AAGTTATCATTCCGATTATTTCTCAAACAGGAAAAAAGGTAGGAGAAGATTTCTATATTGGATATTCTCCTGAGAGAATT
GATCCAGCTAATAGTCAATATTCAGTTCAAACGATTCCAAAAGTCATTAGTGGACAAACAGAAATGTGTAAACAAAAAGT
ACAGGCTTTGTATAGCACTATATTTGATGTAGTTGTTCCAGTTAGCTCTCCAAAAGTAGCAGAAATGTGTAAGCTATTTG
AAAATATTCAGCGCTTAGTCAATATTTCATTAGTAAATGAGTTAAATACACTATGTGAAAGTTTAGGAATTGATTTTTAT
GAGGCACTTGAAGCGGCATCTACAAAACCATTTGGATTTACCCCATATTGGCCAGGACCAGGAATAGGGGGACACTGTAT
TCCGGTAGATCCTTTATATTTCCAGTGGAGAATAAAAAAGAATGGAGCAATGAGTCAATTAATTGAGGCGGCACATGTAA
TTAATGAGGAAATGCCAGAAAAAATGGTCCGGAAAGTAAAAGGTGTGGTGCAATCACCTGCAACGATTTTAATTGTAGGG
ATTGCATATAAAAAAGATGTAAATGACTTAAGAGAATCACCGGCGTTGCCAATTATTGAATTGTTAATAAAAGCAGGATA
TGAGATAGCGTATCACGATCCATATATTTCTTCTGCAAAATTTGGAGATAAGGTGTATCAATCTGTTTCTTTGGATGAAC
AAGTCGTTAAACAAGCGGATTGTATTTTAATTTTAACAGACCACTCTAATATCGATTGGAAGGTTTTTAAAGGGATAAAG
CAAGTCGTAGATACACGTGGAATTATAAAGAAGGTGAGTGTATGA

Upstream 100 bases:

>100_bases
GCATATTTATTGCAATCCACAGACGAGCGCGGGAGTTTTACAGATGGAGAGCGGAATAGAAATATAATTCAACAATTGAG
AAAGGAAGAAGAGAATACAG

Downstream 100 bases:

>100_bases
GTAAGAAATGTTTAATCACAGGTGGAGCAGGATTTATTGGATCGCATTTAGCTGAAGAGCTGGTGAAAAGAGGTTATGAT
GTCACTATCGTTGATAACTT

Product: udp-glucose/gdp-mannose dehydrogenase family

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNVSNTVAIIGLGYVGLPLAVHFAERGHTVLGLDKDARKIESIIQGESYIPDVSSKSLQSLLTRKKLIVNTPDQGVADFQ
NSDYVIVTVPTPINEQREPDLSALISASHYIQQHLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKVGEDFYIGYSPERI
DPANSQYSVQTIPKVISGQTEMCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVRKVKGVVQSPATILIVG
IAYKKDVNDLRESPALPIIELLIKAGYEIAYHDPYISSAKFGDKVYQSVSLDEQVVKQADCILILTDHSNIDWKVFKGIK
QVVDTRGIIKKVSV

Sequences:

>Translated_414_residues
MNVSNTVAIIGLGYVGLPLAVHFAERGHTVLGLDKDARKIESIIQGESYIPDVSSKSLQSLLTRKKLIVNTPDQGVADFQ
NSDYVIVTVPTPINEQREPDLSALISASHYIQQHLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKVGEDFYIGYSPERI
DPANSQYSVQTIPKVISGQTEMCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVRKVKGVVQSPATILIVG
IAYKKDVNDLRESPALPIIELLIKAGYEIAYHDPYISSAKFGDKVYQSVSLDEQVVKQADCILILTDHSNIDWKVFKGIK
QVVDTRGIIKKVSV
>Mature_414_residues
MNVSNTVAIIGLGYVGLPLAVHFAERGHTVLGLDKDARKIESIIQGESYIPDVSSKSLQSLLTRKKLIVNTPDQGVADFQ
NSDYVIVTVPTPINEQREPDLSALISASHYIQQHLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKVGEDFYIGYSPERI
DPANSQYSVQTIPKVISGQTEMCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVRKVKGVVQSPATILIVG
IAYKKDVNDLRESPALPIIELLIKAGYEIAYHDPYISSAKFGDKVYQSVSLDEQVVKQADCILILTDHSNIDWKVFKGIK
QVVDTRGIIKKVSV

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=432, Percent_Identity=31.712962962963, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788340, Length=413, Percent_Identity=21.3075060532688, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17136908, Length=399, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45843; Mature: 45843

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSNTVAIIGLGYVGLPLAVHFAERGHTVLGLDKDARKIESIIQGESYIPDVSSKSLQS
CCCCCEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHH
LLTRKKLIVNTPDQGVADFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQHLQKGQT
HHHHHHHEEECCCCCCHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
FIFESSTYPGTLEEVIIPIISQTGKKVGEDFYIGYSPERIDPANSQYSVQTIPKVISGQT
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCH
EMCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPE
HHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
KMVRKVKGVVQSPATILIVGIAYKKDVNDLRESPALPIIELLIKAGYEIAYHDPYISSAK
HHHHHHHHHHCCCCEEEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHH
FGDKVYQSVSLDEQVVKQADCILILTDHSNIDWKVFKGIKQVVDTRGIIKKVSV
HHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVSNTVAIIGLGYVGLPLAVHFAERGHTVLGLDKDARKIESIIQGESYIPDVSSKSLQS
CCCCCEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHH
LLTRKKLIVNTPDQGVADFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQHLQKGQT
HHHHHHHEEECCCCCCHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
FIFESSTYPGTLEEVIIPIISQTGKKVGEDFYIGYSPERIDPANSQYSVQTIPKVISGQT
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCH
EMCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFY
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLIEAAHVINEEMPE
HHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
KMVRKVKGVVQSPATILIVGIAYKKDVNDLRESPALPIIELLIKAGYEIAYHDPYISSAK
HHHHHHHHHHCCCCEEEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHH
FGDKVYQSVSLDEQVVKQADCILILTDHSNIDWKVFKGIKQVVDTRGIIKKVSV
HHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]