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The map label for this gene is argE [H]

Identifier: 222094101

GI number: 222094101

Start: 379358

End: 380506

Strand: Direct

Name: argE [H]

Synonym: BCQ_0394

Alternate gene names: 222094101

Gene position: 379358-380506 (Clockwise)

Preceding gene: 222094100

Following gene: 222094102

Centisome position: 7.28

GC content: 30.81

Gene sequence:

>1149_bases
ATGGTAATAGATATTCTAAAGGATATAGTGAAAATTAATACAGCTAATCCCGGTGGGAATACAAAAGACTTAATAAATTA
TATTATAAAAAAAATAAATAAGTATGATTTTGAATATGAAATATTTAAGACCAGTGAGTCAAAAGTCAATTTAATTATAA
AAGTAAGAGGTAAAGTTAATAAAACAGTTGTGTTGAATGGTCATCTTGATACAAAGCCTTACGGAAATATGAATGAATGG
AAGTACGATCCATATGCTGCTACTGAAGAGAACAAGCGTATCTATGGTTTAGGTGCATGTGATATGAAGGCAGGAGTAGC
TTCTATGATTACTCTTTTATGTACAATAGGGGAAGAAAAATTAATTCCAAGGTGGAATTTAGAATTTCATTTTGTAGATG
ATGAGGAAAATAATAGTACATATGGAATGAAGAGTTTGTTAAATTCGAATATTTTACAGAGAGATTTGTATGATTTAGCA
GTTGTGTGTGAACCTACTGAAAATAGTCTAGTATTAGAATCTTTGGGGAATTCTTGGAAGATAATTAAAGTAAAGGGGAA
GAAAGCCCATGCTGGCCATTATGAAGAAGGGGTAAACGCTAACGAAGTATTGGCAAATGTATTAATAAAGGCTCAGAAGA
AAATCAGCAAAATGAAAGGAGAAAATCCATCTTTTCCAATGTTCCCTAATATTAATATAGGAATTTTCAAAGGTGGAGAT
CATCCAGGATCTGTAACGGATTATTCTGAAGCTGTTATAGACATTAGGGTAAGTAAAGAGTTTGAAAAAAAGATGATATT
GGAAGAAATAGAAAATGTTCTTGAAGAGTATGATGTGCATTATCAAATCAATGATTACCTTCCAGAGATGTATTCATGGG
ATTATAAAAATTTATCAACTGAATTTTCAAGTGAGTGTTTAAACATATTAATGGATAAATTTAAAGATACTTTTAAGCAA
GTTATAGCAAAAAATAAATTTTATGGTGGCTCCGATGCTGGCTATTATGCCGAAAAATTAGGGGTTCCTACTATTATTTT
TGGTCCAGGTAGTTTACAACAGGCTCATCAACCAAATGAATGGGTCAATATTAAAGGTGTTATGGATCATTTTAAGATTT
TACAGAAATGGATGATTGATATTGATTGA

Upstream 100 bases:

>100_bases
TTACTTGTAAAGACTTTTGTGAAAGTGATTGTGAAGGTTTAGTGATGTGTCCGATGGGAATTGAATTGAAAAAATTTGTT
GGTTAGTGAGGAGAGAATAA

Downstream 100 bases:

>100_bases
TATTGTTGGGAAGGGAAACATGGCTGCGCATTATCGGGAAATTATATCCGGATATTCGAAATTTAAAAAGTCACCTAATA
AGAATATGATTATTGCCATA

Product: acetylornithine deacetylase

Products: acetate; L-ornithine

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MVIDILKDIVKINTANPGGNTKDLINYIIKKINKYDFEYEIFKTSESKVNLIIKVRGKVNKTVVLNGHLDTKPYGNMNEW
KYDPYAATEENKRIYGLGACDMKAGVASMITLLCTIGEEKLIPRWNLEFHFVDDEENNSTYGMKSLLNSNILQRDLYDLA
VVCEPTENSLVLESLGNSWKIIKVKGKKAHAGHYEEGVNANEVLANVLIKAQKKISKMKGENPSFPMFPNINIGIFKGGD
HPGSVTDYSEAVIDIRVSKEFEKKMILEEIENVLEEYDVHYQINDYLPEMYSWDYKNLSTEFSSECLNILMDKFKDTFKQ
VIAKNKFYGGSDAGYYAEKLGVPTIIFGPGSLQQAHQPNEWVNIKGVMDHFKILQKWMIDID

Sequences:

>Translated_382_residues
MVIDILKDIVKINTANPGGNTKDLINYIIKKINKYDFEYEIFKTSESKVNLIIKVRGKVNKTVVLNGHLDTKPYGNMNEW
KYDPYAATEENKRIYGLGACDMKAGVASMITLLCTIGEEKLIPRWNLEFHFVDDEENNSTYGMKSLLNSNILQRDLYDLA
VVCEPTENSLVLESLGNSWKIIKVKGKKAHAGHYEEGVNANEVLANVLIKAQKKISKMKGENPSFPMFPNINIGIFKGGD
HPGSVTDYSEAVIDIRVSKEFEKKMILEEIENVLEEYDVHYQINDYLPEMYSWDYKNLSTEFSSECLNILMDKFKDTFKQ
VIAKNKFYGGSDAGYYAEKLGVPTIIFGPGSLQQAHQPNEWVNIKGVMDHFKILQKWMIDID
>Mature_382_residues
MVIDILKDIVKINTANPGGNTKDLINYIIKKINKYDFEYEIFKTSESKVNLIIKVRGKVNKTVVLNGHLDTKPYGNMNEW
KYDPYAATEENKRIYGLGACDMKAGVASMITLLCTIGEEKLIPRWNLEFHFVDDEENNSTYGMKSLLNSNILQRDLYDLA
VVCEPTENSLVLESLGNSWKIIKVKGKKAHAGHYEEGVNANEVLANVLIKAQKKISKMKGENPSFPMFPNINIGIFKGGD
HPGSVTDYSEAVIDIRVSKEFEKKMILEEIENVLEEYDVHYQINDYLPEMYSWDYKNLSTEFSSECLNILMDKFKDTFKQ
VIAKNKFYGGSDAGYYAEKLGVPTIIFGPGSLQQAHQPNEWVNIKGVMDHFKILQKWMIDID

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=336, Percent_Identity=25.8928571428571, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789236, Length=370, Percent_Identity=22.1621621621622, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24649212, Length=362, Percent_Identity=22.3756906077348, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16

Molecular weight: Translated: 43573; Mature: 43573

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIDILKDIVKINTANPGGNTKDLINYIIKKINKYDFEYEIFKTSESKVNLIIKVRGKVN
CHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECCCC
KTVVLNGHLDTKPYGNMNEWKYDPYAATEENKRIYGLGACDMKAGVASMITLLCTIGEEK
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
LIPRWNLEFHFVDDEENNSTYGMKSLLNSNILQRDLYDLAVVCEPTENSLVLESLGNSWK
CCCEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEHHHCCCCEE
IIKVKGKKAHAGHYEEGVNANEVLANVLIKAQKKISKMKGENPSFPMFPNINIGIFKGGD
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCC
HPGSVTDYSEAVIDIRVSKEFEKKMILEEIENVLEEYDVHYQINDYLPEMYSWDYKNLST
CCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHCCCHHHCCH
EFSSECLNILMDKFKDTFKQVIAKNKFYGGSDAGYYAEKLGVPTIIFGPGSLQQAHQPNE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEECCCCCHHCCCCCC
WVNIKGVMDHFKILQKWMIDID
EEEHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVIDILKDIVKINTANPGGNTKDLINYIIKKINKYDFEYEIFKTSESKVNLIIKVRGKVN
CHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECCCC
KTVVLNGHLDTKPYGNMNEWKYDPYAATEENKRIYGLGACDMKAGVASMITLLCTIGEEK
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
LIPRWNLEFHFVDDEENNSTYGMKSLLNSNILQRDLYDLAVVCEPTENSLVLESLGNSWK
CCCEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEHHHCCCCEE
IIKVKGKKAHAGHYEEGVNANEVLANVLIKAQKKISKMKGENPSFPMFPNINIGIFKGGD
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCC
HPGSVTDYSEAVIDIRVSKEFEKKMILEEIENVLEEYDVHYQINDYLPEMYSWDYKNLST
CCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHCCCHHHCCH
EFSSECLNILMDKFKDTFKQVIAKNKFYGGSDAGYYAEKLGVPTIIFGPGSLQQAHQPNE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEECCCCCHHCCCCCC
WVNIKGVMDHFKILQKWMIDID
EEEHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-acetyl-L-ornithine; H2O

Specific reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9734814; 9384377 [H]