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The map label for this gene is dgoD1 [H]

Identifier: 221635997

GI number: 221635997

Start: 581127

End: 582281

Strand: Reverse

Name: dgoD1 [H]

Synonym: trd_A0591

Alternate gene names: 221635997

Gene position: 582281-581127 (Counterclockwise)

Preceding gene: 221635998

Following gene: 221635996

Centisome position: 63.45

GC content: 62.68

Gene sequence:

>1155_bases
ATGCGCATCGTCGATGTGAAGACGTACGTACTGGGGACGGCCTGGCGCAATCTGACGTTCGTCGAGGTGCATACCGACGA
GGGGATCACTGGGGTCGGCGAGGCGCGGATGCTCAACCACACGGATGCCCTGTTGGGCTACCTGGCCGAAGCGGTCCCCA
ATCATGTGCTCGGCCGTGACCCGTTTCAGATCGAAGACCTCGTCTTTCACATGATGCGCGACGATTATGCCCGGCCCGAC
TACGTGATGATGTCGGGGATCGCGGCGATCGAGATCGCCTGCTGGGACATCATGGGGAAGGCGCTCGGTCTTCCCGTCTA
TCAGCTTTTGGGTGGCGCGGTACGGGATCGGATCAAGGCGTACGCCAACGGCTGGTATACGGTGGAGCGGACACCGGAGC
AGTTCGCAGAGGCAGCGCGCCGGGTGGTCGAGCGCGGGTACCGTGCGCTCAAGCTCGATCCGTTCGGTGCTGGTTACTAT
GAGCTCGATCTCGCTGAGAAGCGGCGTGTGATCGCACTGGTCGAGGCCGTGCGCGATGCCGTGGGGTCAGAGGTCGAGAT
CTTGATCGAGATGCATGGACGGTTCAATCCGGCGACCGCGATCGAGATGGCACGACTTCTCGAGCCCTACCAGCCGAGTT
GGATCGAGGAGCCGGTGCCGCCGCACAATCTGGCTGCCTTGAAGAAGGTCGCCGAGCAGGTGCGGATCCCGGTGGCGACC
GGCGAGCGGATCCACACTCGGTATGACTTTCGCGAACTTTTCGAGCTCCAGGCAGCCGATATCATCCAACCGGATATCAC
GCATCTGGGTGGACTCCTGGAGACGAAGAAGTTGGCCGCGTGGGCTGATGCGTACTATGTCCTCGTCGCGCCGCACAACG
TCTGCGGCCCGGTCGGAACCGCAGCGAACCTGCATCTGGCTGCCTGCACGACCAACTTCAAGATCCAAGAGCACTTCAAC
GATTTCGCCGAAGCGCACGTGAAGGCAGCGGCACCGGGGGTTCCCGACGTCGTCGATGGCTACTTCCCGCTGCCGCAAGG
GCCGGGCTTAGGCGTCCAGTTGGATCACAGCGTGGTCGCGCAGCATCCGCGGCGGCGCGTCTTTTTCAATCTTTTCGCCG
AAGAGTGGCACCGACGGCAAGCGGAGCGCGAGTGA

Upstream 100 bases:

>100_bases
GATCGTCGCCGAGTTCGCTCGCGGCGAGGCCACTGAGGAGCGTGTCCTGCGAGCGGCGACGGGACAGCGCGTCGCCGCGT
GATTGGAGAAGGAGAAGGCA

Downstream 100 bases:

>100_bases
GGAGCGGACGATGGAGGGGGTCGCGGCGATTCTTCAGCGGCTGGCGCAGCGACACGACTCGCTCGGGATCGTGTGGCTCG
GGCAAGCGAGCGTCGCGCTG

Product: galactonate dehydratase

Products: NA

Alternate protein names: GalD 1 [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRIVDVKTYVLGTAWRNLTFVEVHTDEGITGVGEARMLNHTDALLGYLAEAVPNHVLGRDPFQIEDLVFHMMRDDYARPD
YVMMSGIAAIEIACWDIMGKALGLPVYQLLGGAVRDRIKAYANGWYTVERTPEQFAEAARRVVERGYRALKLDPFGAGYY
ELDLAEKRRVIALVEAVRDAVGSEVEILIEMHGRFNPATAIEMARLLEPYQPSWIEEPVPPHNLAALKKVAEQVRIPVAT
GERIHTRYDFRELFELQAADIIQPDITHLGGLLETKKLAAWADAYYVLVAPHNVCGPVGTAANLHLAACTTNFKIQEHFN
DFAEAHVKAAAPGVPDVVDGYFPLPQGPGLGVQLDHSVVAQHPRRRVFFNLFAEEWHRRQAERE

Sequences:

>Translated_384_residues
MRIVDVKTYVLGTAWRNLTFVEVHTDEGITGVGEARMLNHTDALLGYLAEAVPNHVLGRDPFQIEDLVFHMMRDDYARPD
YVMMSGIAAIEIACWDIMGKALGLPVYQLLGGAVRDRIKAYANGWYTVERTPEQFAEAARRVVERGYRALKLDPFGAGYY
ELDLAEKRRVIALVEAVRDAVGSEVEILIEMHGRFNPATAIEMARLLEPYQPSWIEEPVPPHNLAALKKVAEQVRIPVAT
GERIHTRYDFRELFELQAADIIQPDITHLGGLLETKKLAAWADAYYVLVAPHNVCGPVGTAANLHLAACTTNFKIQEHFN
DFAEAHVKAAAPGVPDVVDGYFPLPQGPGLGVQLDHSVVAQHPRRRVFFNLFAEEWHRRQAERE
>Mature_384_residues
MRIVDVKTYVLGTAWRNLTFVEVHTDEGITGVGEARMLNHTDALLGYLAEAVPNHVLGRDPFQIEDLVFHMMRDDYARPD
YVMMSGIAAIEIACWDIMGKALGLPVYQLLGGAVRDRIKAYANGWYTVERTPEQFAEAARRVVERGYRALKLDPFGAGYY
ELDLAEKRRVIALVEAVRDAVGSEVEILIEMHGRFNPATAIEMARLLEPYQPSWIEEPVPPHNLAALKKVAEQVRIPVAT
GERIHTRYDFRELFELQAADIIQPDITHLGGLLETKKLAAWADAYYVLVAPHNVCGPVGTAANLHLAACTTNFKIQEHFN
DFAEAHVKAAAPGVPDVVDGYFPLPQGPGLGVQLDHSVVAQHPRRRVFFNLFAEEWHRRQAERE

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=401, Percent_Identity=22.9426433915212, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI186972148, Length=323, Percent_Identity=23.5294117647059, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI48994953, Length=374, Percent_Identity=35.5614973262032, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1787864, Length=391, Percent_Identity=28.3887468030691, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI226510960, Length=220, Percent_Identity=32.7272727272727, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 43068; Mature: 43068

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVDVKTYVLGTAWRNLTFVEVHTDEGITGVGEARMLNHTDALLGYLAEAVPNHVLGRD
CEEEEEHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHCCCC
PFQIEDLVFHMMRDDYARPDYVMMSGIAAIEIACWDIMGKALGLPVYQLLGGAVRDRIKA
CCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YANGWYTVERTPEQFAEAARRVVERGYRALKLDPFGAGYYELDLAEKRRVIALVEAVRDA
HHCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHH
VGSEVEILIEMHGRFNPATAIEMARLLEPYQPSWIEEPVPPHNLAALKKVAEQVRIPVAT
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
GERIHTRYDFRELFELQAADIIQPDITHLGGLLETKKLAAWADAYYVLVAPHNVCGPVGT
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCC
AANLHLAACTTNFKIQEHFNDFAEAHVKAAAPGVPDVVDGYFPLPQGPGLGVQLDHSVVA
CCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCEEECHHHHH
QHPRRRVFFNLFAEEWHRRQAERE
HCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIVDVKTYVLGTAWRNLTFVEVHTDEGITGVGEARMLNHTDALLGYLAEAVPNHVLGRD
CEEEEEHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHCCCC
PFQIEDLVFHMMRDDYARPDYVMMSGIAAIEIACWDIMGKALGLPVYQLLGGAVRDRIKA
CCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YANGWYTVERTPEQFAEAARRVVERGYRALKLDPFGAGYYELDLAEKRRVIALVEAVRDA
HHCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHH
VGSEVEILIEMHGRFNPATAIEMARLLEPYQPSWIEEPVPPHNLAALKKVAEQVRIPVAT
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
GERIHTRYDFRELFELQAADIIQPDITHLGGLLETKKLAAWADAYYVLVAPHNVCGPVGT
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCC
AANLHLAACTTNFKIQEHFNDFAEAHVKAAAPGVPDVVDGYFPLPQGPGLGVQLDHSVVA
CCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCEEECHHHHH
QHPRRRVFFNLFAEEWHRRQAERE
HCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA