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The map label for this gene is xdhA [H]

Identifier: 221635806

GI number: 221635806

Start: 387529

End: 389796

Strand: Reverse

Name: xdhA [H]

Synonym: trd_A0400

Alternate gene names: 221635806

Gene position: 389796-387529 (Counterclockwise)

Preceding gene: 221635818

Following gene: 221635805

Centisome position: 42.47

GC content: 66.18

Gene sequence:

>2268_bases
ATGACGACCGTGCTCGGGAAACCGCTCAAGCGACGCGATGCCGAACCGAAGTTGCGCGGCGACGCGCGTTATACCGACGA
CCTGCACCTTCCCGGGCTTCTCCATGCCCGGCTCGTCACCAGTCCGTACGCACACGCCCGGATCGTCCGCATCGATTGCG
ACGCAGCACGCCGCACCCCGGGTGTCGTCGCCGTTTTCACTGGCCACGATCTCCTTCCCGAGGGCCCGGAACCGGCCGAG
CGAGCCCGGCATCTTTTGGCACGGGACAAGGTCATCTACGCTGGCCAGCCGGTCGCGATCGTCGTCGCCGAATCACCGTA
CGTGGCCGCCGATGCAGCGGCACTCGTCGAGGTCGAATACGACGAACTTCCAGCGGTCGTCGATCCACTGGCGGCCATGA
CACCCGAGGCCCCGGTGATCCGCCCCAAAGAACTCGAAGGCGAGTGGGCAGAAGCCGGCATGCATGCCACGGTATCGGGC
GGAGAAGAACTCGATGTCCGGCGTCTGCCGGCCAACGTCACCAACGCTGTGCGCTTCCAGCGGGGTGACGTGATGCAGGG
TTTCGCCAGCGCCGATGTCGTGATCGAGCGAACCTACCGGACACCATTCGTCCACCAGGCATACCTCGAGCCGCATGCCT
CGGTGGCTGTGCCCCGACCCGATGGCGGCGTCACCATCTATACGACCACACAGGGTCAGTTCTATTGCCGCAACGTGACC
GCGACCACGCTCGGTCTCCCCCACGAAATGGTGACGATCGTTCCGATGGAGGTCGGAGGCGGCTTCGGCGGCAAGACCGT
CCTCCTCGAGCCTCTGGTCGCAGCGGTCGCATTGCGGCTCGGCAGGCCGGTCAAGCTCGTCCTGACCCGAACCGAAGAGT
TCCTGCTCGCCACACCGGCTCCCGCCGCGATCTTCGAGCTCCGGGCTGGTGCTCGCCGCGACGGCACGCTCACCGCGCTC
CGCGCCCGGGTCATCTTCGACTCGGGTGCTTACCCCGGCGCGCCAGTCACTATCGCGCTCCTTCTCTTGGGTGGAACCTA
CCGCTGGGAACATCTCGATCTCCTCGGCTACGAGGTTCTCACCAATAAGCCAGGGACGGGGGCCTATCGCGCACCAGGAG
TTCCCCAAGCCACCTTTGCGCTCGAGCAGCTGATCGACGAACTCGCGCGGGCGATCGGGCAGGATCCCCTCGAGCTGCGT
CTCCGCAACGCCGCGCGAACGGGTGATCTTCAGCCGAACGGTGTCCCCTGGCCTCCGATCGGGCTCGTCGACGTCCTCGA
GCGGGCCCGGCAACACCCCCTCTGGCGTTCACGCCAGCGCCGCCCCAACGAAGGCTGGGGCATCGCGGTCGGTGGATGGC
CGGGCGGTATCGAACCCTGTGCAGCGAACATTCGGCTGAATCACGACGGCACCTTCACCGTCACGCTCGGTGCCATCGAC
ATTACCGGCACGCATACGGTTCTCGCCATGATCGCGGCAGAAGTGCTGGAACAGCCAGTCGAGCGAATCCGGGTCAAGCT
CCTGCCGACCGACGGTGCTCCCTACGCGGGGATGAGCGGAGGGAGCAAGATCACCTACACGGTCGGACTCGCGGTGCAAG
CAGCAGCGGAGGATGCCAAACGGCAGCTCTTGGAGATCGCTGCCAACGAACTCGAAGCTGCACCCGAGGACCTGGAACTC
GTCGATGGCGCGATCCGCGTCCGCGGTATGCCCGATCGGCAGATCACGCTCAGCGAGATCGCACACCGGAGCATGGTCTT
CGGTGGCAAATATGCACCCGTCTACGGCACCGGCCGGAGCGTCGTCCGCCAGCAGTCCCCCGGCTTCAACGCGCAAATCG
CACACGTCGCGGTCGACCCGGACACCGGCGAGGTGGAGGTGCTCGATCTGGTCGCGATCCAGGACGTCGGGCGCGCACTC
AACCCAGCACTCGTCGAGGAGCAGGTGCACGGTGGTGTCGGCCAAGGTATCGGGTGGGCTCTGCACGAGGCGATGCGCTG
GAGCGAGAACGGCCAACCGCTCAACCCCTCCTTCCTCGACTACGATCTCCCCAAAGCGAGCCAGCTACCGCCGATCGCCG
TCGAACTCGTCGAGGTTCCCTCGCCGATCGGTCCGTTCGGGGCGAAGGGAGTCGGTGAGCCGCCCGTCGTTCCGACCGCT
GCAGCCATCGCCAACGCGATCGCTGATGCCATCGGCGTGCACCTGAGCGAGCTCCCCATCACGCCCGAGCGCGTGCTCGC
TGCACTGCGCGACAAAGCAGTGAGTTGA

Upstream 100 bases:

>100_bases
CACCGCCGACACTGTCCCGATCGGACAGCTTCTCGGTGAGCGGAGAGCATCGTACACTGGGTCAGCGTGGTGGGAACGAC
GGGGAAGGGAGCCTCGAGCG

Downstream 100 bases:

>100_bases
GCGAGTAAGGTATCCAATTGGAGAGCAGCTGGGGTCGATCCACGGCCGCGGATCGACTCCAGGCGGGTTCGCAGCGCGGA
GAGCGCAGCACGCGAGAGCA

Product: xanthine dehydrogenase molybdenum-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MTTVLGKPLKRRDAEPKLRGDARYTDDLHLPGLLHARLVTSPYAHARIVRIDCDAARRTPGVVAVFTGHDLLPEGPEPAE
RARHLLARDKVIYAGQPVAIVVAESPYVAADAAALVEVEYDELPAVVDPLAAMTPEAPVIRPKELEGEWAEAGMHATVSG
GEELDVRRLPANVTNAVRFQRGDVMQGFASADVVIERTYRTPFVHQAYLEPHASVAVPRPDGGVTIYTTTQGQFYCRNVT
ATTLGLPHEMVTIVPMEVGGGFGGKTVLLEPLVAAVALRLGRPVKLVLTRTEEFLLATPAPAAIFELRAGARRDGTLTAL
RARVIFDSGAYPGAPVTIALLLLGGTYRWEHLDLLGYEVLTNKPGTGAYRAPGVPQATFALEQLIDELARAIGQDPLELR
LRNAARTGDLQPNGVPWPPIGLVDVLERARQHPLWRSRQRRPNEGWGIAVGGWPGGIEPCAANIRLNHDGTFTVTLGAID
ITGTHTVLAMIAAEVLEQPVERIRVKLLPTDGAPYAGMSGGSKITYTVGLAVQAAAEDAKRQLLEIAANELEAAPEDLEL
VDGAIRVRGMPDRQITLSEIAHRSMVFGGKYAPVYGTGRSVVRQQSPGFNAQIAHVAVDPDTGEVEVLDLVAIQDVGRAL
NPALVEEQVHGGVGQGIGWALHEAMRWSENGQPLNPSFLDYDLPKASQLPPIAVELVEVPSPIGPFGAKGVGEPPVVPTA
AAIANAIADAIGVHLSELPITPERVLAALRDKAVS

Sequences:

>Translated_755_residues
MTTVLGKPLKRRDAEPKLRGDARYTDDLHLPGLLHARLVTSPYAHARIVRIDCDAARRTPGVVAVFTGHDLLPEGPEPAE
RARHLLARDKVIYAGQPVAIVVAESPYVAADAAALVEVEYDELPAVVDPLAAMTPEAPVIRPKELEGEWAEAGMHATVSG
GEELDVRRLPANVTNAVRFQRGDVMQGFASADVVIERTYRTPFVHQAYLEPHASVAVPRPDGGVTIYTTTQGQFYCRNVT
ATTLGLPHEMVTIVPMEVGGGFGGKTVLLEPLVAAVALRLGRPVKLVLTRTEEFLLATPAPAAIFELRAGARRDGTLTAL
RARVIFDSGAYPGAPVTIALLLLGGTYRWEHLDLLGYEVLTNKPGTGAYRAPGVPQATFALEQLIDELARAIGQDPLELR
LRNAARTGDLQPNGVPWPPIGLVDVLERARQHPLWRSRQRRPNEGWGIAVGGWPGGIEPCAANIRLNHDGTFTVTLGAID
ITGTHTVLAMIAAEVLEQPVERIRVKLLPTDGAPYAGMSGGSKITYTVGLAVQAAAEDAKRQLLEIAANELEAAPEDLEL
VDGAIRVRGMPDRQITLSEIAHRSMVFGGKYAPVYGTGRSVVRQQSPGFNAQIAHVAVDPDTGEVEVLDLVAIQDVGRAL
NPALVEEQVHGGVGQGIGWALHEAMRWSENGQPLNPSFLDYDLPKASQLPPIAVELVEVPSPIGPFGAKGVGEPPVVPTA
AAIANAIADAIGVHLSELPITPERVLAALRDKAVS
>Mature_754_residues
TTVLGKPLKRRDAEPKLRGDARYTDDLHLPGLLHARLVTSPYAHARIVRIDCDAARRTPGVVAVFTGHDLLPEGPEPAER
ARHLLARDKVIYAGQPVAIVVAESPYVAADAAALVEVEYDELPAVVDPLAAMTPEAPVIRPKELEGEWAEAGMHATVSGG
EELDVRRLPANVTNAVRFQRGDVMQGFASADVVIERTYRTPFVHQAYLEPHASVAVPRPDGGVTIYTTTQGQFYCRNVTA
TTLGLPHEMVTIVPMEVGGGFGGKTVLLEPLVAAVALRLGRPVKLVLTRTEEFLLATPAPAAIFELRAGARRDGTLTALR
ARVIFDSGAYPGAPVTIALLLLGGTYRWEHLDLLGYEVLTNKPGTGAYRAPGVPQATFALEQLIDELARAIGQDPLELRL
RNAARTGDLQPNGVPWPPIGLVDVLERARQHPLWRSRQRRPNEGWGIAVGGWPGGIEPCAANIRLNHDGTFTVTLGAIDI
TGTHTVLAMIAAEVLEQPVERIRVKLLPTDGAPYAGMSGGSKITYTVGLAVQAAAEDAKRQLLEIAANELEAAPEDLELV
DGAIRVRGMPDRQITLSEIAHRSMVFGGKYAPVYGTGRSVVRQQSPGFNAQIAHVAVDPDTGEVEVLDLVAIQDVGRALN
PALVEEQVHGGVGQGIGWALHEAMRWSENGQPLNPSFLDYDLPKASQLPPIAVELVEVPSPIGPFGAKGVGEPPVVPTAA
AIANAIADAIGVHLSELPITPERVLAALRDKAVS

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=789, Percent_Identity=25.6020278833967, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI71773480, Length=796, Percent_Identity=25.251256281407, Blast_Score=191, Evalue=3e-48,
Organism=Escherichia coli, GI1789230, Length=778, Percent_Identity=33.9331619537275, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1789246, Length=797, Percent_Identity=31.3676286072773, Blast_Score=297, Evalue=2e-81,
Organism=Escherichia coli, GI1786478, Length=773, Percent_Identity=31.8240620957309, Blast_Score=230, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17540638, Length=795, Percent_Identity=23.8993710691824, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17539860, Length=759, Percent_Identity=24.2424242424242, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566215, Length=549, Percent_Identity=24.5901639344262, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17737937, Length=789, Percent_Identity=27.7566539923954, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24647193, Length=783, Percent_Identity=24.3933588761175, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24647199, Length=737, Percent_Identity=23.3378561736771, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24647201, Length=735, Percent_Identity=23.1292517006803, Blast_Score=129, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24647195, Length=755, Percent_Identity=24.2384105960265, Blast_Score=119, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24647197, Length=745, Percent_Identity=24.4295302013423, Blast_Score=117, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 80681; Mature: 80550

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVLGKPLKRRDAEPKLRGDARYTDDLHLPGLLHARLVTSPYAHARIVRIDCDAARRTP
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCHHCCCC
GVVAVFTGHDLLPEGPEPAERARHLLARDKVIYAGQPVAIVVAESPYVAADAAALVEVEY
CEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEECCCCEEEEEECCCCEECCCEEEEEEEH
DELPAVVDPLAAMTPEAPVIRPKELEGEWAEAGMHATVSGGEELDVRRLPANVTNAVRFQ
HHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCEECCCCHHHHHHCC
RGDVMQGFASADVVIERTYRTPFVHQAYLEPHASVAVPRPDGGVTIYTTTQGQFYCRNVT
CCCHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCEEEECCCCCEEEEEECCCEEEEEECE
ATTLGLPHEMVTIVPMEVGGGFGGKTVLLEPLVAAVALRLGRPVKLVLTRTEEFLLATPA
EEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCC
PAAIFELRAGARRDGTLTALRARVIFDSGAYPGAPVTIALLLLGGTYRWEHLDLLGYEVL
CHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEHHHCCCEE
TNKPGTGAYRAPGVPQATFALEQLIDELARAIGQDPLELRLRNAARTGDLQPNGVPWPPI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCC
GLVDVLERARQHPLWRSRQRRPNEGWGIAVGGWPGGIEPCAANIRLNHDGTFTVTLGAID
CHHHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEEEEEE
ITGTHTVLAMIAAEVLEQPVERIRVKLLPTDGAPYAGMSGGSKITYTVGLAVQAAAEDAK
ECCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCEEEEEEEEEEHHHHHHHH
RQLLEIAANELEAAPEDLELVDGAIRVRGMPDRQITLSEIAHRSMVFGGKYAPVYGTGRS
HHHHHHHHHHHHCCCCHHHHHCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCCEECCCHH
VVRQQSPGFNAQIAHVAVDPDTGEVEVLDLVAIQDVGRALNPALVEEQVHGGVGQGIGWA
HHHHCCCCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHH
LHEAMRWSENGQPLNPSFLDYDLPKASQLPPIAVELVEVPSPIGPFGAKGVGEPPVVPTA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHH
AAIANAIADAIGVHLSELPITPERVLAALRDKAVS
HHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTVLGKPLKRRDAEPKLRGDARYTDDLHLPGLLHARLVTSPYAHARIVRIDCDAARRTP
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCHHCCCC
GVVAVFTGHDLLPEGPEPAERARHLLARDKVIYAGQPVAIVVAESPYVAADAAALVEVEY
CEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEECCCCEEEEEECCCCEECCCEEEEEEEH
DELPAVVDPLAAMTPEAPVIRPKELEGEWAEAGMHATVSGGEELDVRRLPANVTNAVRFQ
HHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCEECCCCHHHHHHCC
RGDVMQGFASADVVIERTYRTPFVHQAYLEPHASVAVPRPDGGVTIYTTTQGQFYCRNVT
CCCHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCEEEECCCCCEEEEEECCCEEEEEECE
ATTLGLPHEMVTIVPMEVGGGFGGKTVLLEPLVAAVALRLGRPVKLVLTRTEEFLLATPA
EEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCC
PAAIFELRAGARRDGTLTALRARVIFDSGAYPGAPVTIALLLLGGTYRWEHLDLLGYEVL
CHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEHHHCCCEE
TNKPGTGAYRAPGVPQATFALEQLIDELARAIGQDPLELRLRNAARTGDLQPNGVPWPPI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCC
GLVDVLERARQHPLWRSRQRRPNEGWGIAVGGWPGGIEPCAANIRLNHDGTFTVTLGAID
CHHHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEEEEEE
ITGTHTVLAMIAAEVLEQPVERIRVKLLPTDGAPYAGMSGGSKITYTVGLAVQAAAEDAK
ECCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCEEEEEEEEEEHHHHHHHH
RQLLEIAANELEAAPEDLELVDGAIRVRGMPDRQITLSEIAHRSMVFGGKYAPVYGTGRS
HHHHHHHHHHHHCCCCHHHHHCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCCEECCCHH
VVRQQSPGFNAQIAHVAVDPDTGEVEVLDLVAIQDVGRALNPALVEEQVHGGVGQGIGWA
HHHHCCCCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHH
LHEAMRWSENGQPLNPSFLDYDLPKASQLPPIAVELVEVPSPIGPFGAKGVGEPPVVPTA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHH
AAIANAIADAIGVHLSELPITPERVLAALRDKAVS
HHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]