| Definition | Thermomicrobium roseum DSM 5159 plasmid unnamed, complete sequence. |
|---|---|
| Accession | NC_011961 |
| Length | 917,738 |
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The map label for this gene is fabG [C]
Identifier: 221635635
GI number: 221635635
Start: 217732
End: 218556
Strand: Reverse
Name: fabG [C]
Synonym: trd_A0229
Alternate gene names: 221635635
Gene position: 218556-217732 (Counterclockwise)
Preceding gene: 221635636
Following gene: 221635631
Centisome position: 23.81
GC content: 64.48
Gene sequence:
>825_bases GTGATGATGATGTTCGGACAACTCTGCGATCTCAGTGGGCTCGTCGCATTGGTGACCGGTGCCGGCGGAGGGGAACGTGG GGGACTCGGCGCAGCGATCGCACGAGTCCTGGCACAAGCTGGCGCTCAGGTGGCTGTGAACGATCTCGCACTGGAAGACG CGGAAGCGACGGCCAGCATGATCCGCGCCCTCGGCCTGGTTGCCGAAGCGCTGCCAGCCGATGTCGCCGATCCGGAGCAG GCCGACCAGCTCGTCGCCCGCGTCATCGAACGGTTCGGTAAGATCGATATCCTCGTCAACAAAGCCGAGTATCATTCCCG TGCCTATCGTCCCGACGAAATCCCGACCGAAGAGTGGCAGCGGAGCGTCGCCGTCAATGTCCACGCTCCCTTCTACCTCA GCCGAGCGGCTGTCCGCGACATGCGTCGGCGCAAGTTCGGGCGCATCATCAACGTGTCCAACATCGCTGCCATTCGCGCC AGTGTCCTGCACGGGACGCCGTATGTGGCCACCAAGGAAGCGCTCTACGGCTTCACCCGCCACCTGGCCACCGAGGTCGC CCAACACGGCATCACGGTCAACGCCATTCTGCCCGGCTTCGTCCTCACCCCCAAGCTGGCAGCTCTCTGGCCAGACGAGC GGATCGCCAGGCTGGCCCCGACTATCCCCGCGCTGCGTGCTGGGACTCCGGAGGAAATTGCGAGTCTCGTGGTCTACCTG GCCAGTCCGGAGGCTGGCTACCTCACTGGTGCCGCGATCCCGATCGATGGGGCCGTCTCCATCGTTCCGGGTGGTCGCAT GGATCCGGACAACTGCTTCGTTTGA
Upstream 100 bases:
>100_bases CGACTTCGCTGAACTGAAGCGACGGAGCGGCAAGGATACCGGAGACTGACGTGTCGTCCAGCAGTGGGCACGACGAACTC TCACGGGAAAGGAGCCGATC
Downstream 100 bases:
>100_bases CGGGTGTCGGAACCTCTCGGCCGTCGAACGTGCGAGCCCGCCAGGAGGAACGAGCGGGAGCCGGCGCGGTATCCTCCGCG CCGGCTGTTCTACTCAGGTG
Product: D-beta-hydroxybutyrate dehydrogenase (bdh) (3-hydroxybutyrate dehydrogenase) (3-hbdh)
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 274; Mature: 274
Protein sequence:
>274_residues MMMMFGQLCDLSGLVALVTGAGGGERGGLGAAIARVLAQAGAQVAVNDLALEDAEATASMIRALGLVAEALPADVADPEQ ADQLVARVIERFGKIDILVNKAEYHSRAYRPDEIPTEEWQRSVAVNVHAPFYLSRAAVRDMRRRKFGRIINVSNIAAIRA SVLHGTPYVATKEALYGFTRHLATEVAQHGITVNAILPGFVLTPKLAALWPDERIARLAPTIPALRAGTPEEIASLVVYL ASPEAGYLTGAAIPIDGAVSIVPGGRMDPDNCFV
Sequences:
>Translated_274_residues MMMMFGQLCDLSGLVALVTGAGGGERGGLGAAIARVLAQAGAQVAVNDLALEDAEATASMIRALGLVAEALPADVADPEQ ADQLVARVIERFGKIDILVNKAEYHSRAYRPDEIPTEEWQRSVAVNVHAPFYLSRAAVRDMRRRKFGRIINVSNIAAIRA SVLHGTPYVATKEALYGFTRHLATEVAQHGITVNAILPGFVLTPKLAALWPDERIARLAPTIPALRAGTPEEIASLVVYL ASPEAGYLTGAAIPIDGAVSIVPGGRMDPDNCFV >Mature_274_residues MMMMFGQLCDLSGLVALVTGAGGGERGGLGAAIARVLAQAGAQVAVNDLALEDAEATASMIRALGLVAEALPADVADPEQ ADQLVARVIERFGKIDILVNKAEYHSRAYRPDEIPTEEWQRSVAVNVHAPFYLSRAAVRDMRRRKFGRIINVSNIAAIRA SVLHGTPYVATKEALYGFTRHLATEVAQHGITVNAILPGFVLTPKLAALWPDERIARLAPTIPALRAGTPEEIASLVVYL ASPEAGYLTGAAIPIDGAVSIVPGGRMDPDNCFV
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=34.2741935483871, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=31.1538461538462, Blast_Score=109, Evalue=3e-24, Organism=Homo sapiens, GI19923817, Length=271, Percent_Identity=28.4132841328413, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=32.258064516129, Blast_Score=104, Evalue=7e-23, Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=32.9896907216495, Blast_Score=102, Evalue=5e-22, Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=32.0833333333333, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=30.3149606299213, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI66933014, Length=195, Percent_Identity=34.8717948717949, Blast_Score=98, Evalue=9e-21, Organism=Homo sapiens, GI4758504, Length=266, Percent_Identity=32.3308270676692, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=33.6787564766839, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=30.8, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI31542939, Length=214, Percent_Identity=31.3084112149533, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=30.8641975308642, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI4504505, Length=238, Percent_Identity=29.8319327731092, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI210032110, Length=212, Percent_Identity=27.3584905660377, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI10190704, Length=246, Percent_Identity=29.2682926829268, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI83715985, Length=266, Percent_Identity=30.4511278195489, Blast_Score=75, Evalue=9e-14, Organism=Homo sapiens, GI7706318, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI4503301, Length=246, Percent_Identity=24.390243902439, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=36.2204724409449, Blast_Score=141, Evalue=4e-35, Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=34.5098039215686, Blast_Score=135, Evalue=3e-33, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=34.1085271317829, Blast_Score=124, Evalue=9e-30, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=33.8645418326693, Blast_Score=119, Evalue=2e-28, Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=33.7349397590361, Blast_Score=119, Evalue=2e-28, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=33.0612244897959, Blast_Score=117, Evalue=1e-27, Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=2e-26, Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=34.412955465587, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=35.1464435146443, Blast_Score=108, Evalue=5e-25, Organism=Escherichia coli, GI1786812, Length=264, Percent_Identity=30.6818181818182, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI2367365, Length=236, Percent_Identity=34.3220338983051, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1789057, Length=251, Percent_Identity=30.2788844621514, Blast_Score=88, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17555706, Length=262, Percent_Identity=32.0610687022901, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=35.0393700787402, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=32.4626865671642, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=31.3653136531365, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=30.4, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=30.7116104868914, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=29.4776119402985, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=31.4814814814815, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17538182, Length=266, Percent_Identity=34.2105263157895, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17563726, Length=253, Percent_Identity=29.2490118577075, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=31.5384615384615, Blast_Score=100, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=29.0441176470588, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562906, Length=275, Percent_Identity=29.4545454545455, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI193204405, Length=274, Percent_Identity=31.3868613138686, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=30.3846153846154, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17560220, Length=283, Percent_Identity=30.0353356890459, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562908, Length=279, Percent_Identity=30.4659498207885, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=30.7086614173228, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=30.7407407407407, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17551412, Length=275, Percent_Identity=29.0909090909091, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=29.3233082706767, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=29.7397769516729, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17508651, Length=263, Percent_Identity=28.5171102661597, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=27.906976744186, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17568967, Length=194, Percent_Identity=32.9896907216495, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17531453, Length=275, Percent_Identity=28.3636363636364, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=28.0155642023346, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=26.3779527559055, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI71994604, Length=265, Percent_Identity=29.4339622641509, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17508895, Length=252, Percent_Identity=28.968253968254, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI193203115, Length=252, Percent_Identity=24.2063492063492, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193203117, Length=251, Percent_Identity=24.3027888446215, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17564282, Length=263, Percent_Identity=25.0950570342205, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17561272, Length=240, Percent_Identity=28.75, Blast_Score=70, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6322861, Length=235, Percent_Identity=33.6170212765957, Blast_Score=88, Evalue=1e-18, Organism=Saccharomyces cerevisiae, GI6324126, Length=264, Percent_Identity=28.030303030303, Blast_Score=78, Evalue=2e-15, Organism=Drosophila melanogaster, GI21355319, Length=263, Percent_Identity=34.9809885931559, Blast_Score=130, Evalue=7e-31, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=35.1778656126482, Blast_Score=122, Evalue=3e-28, Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=36.2204724409449, Blast_Score=114, Evalue=5e-26, Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.5019305019305, Blast_Score=100, Evalue=9e-22, Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=30.6772908366534, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=30.6772908366534, Blast_Score=89, Evalue=4e-18, Organism=Drosophila melanogaster, GI17737361, Length=266, Percent_Identity=30.8270676691729, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24644337, Length=260, Percent_Identity=29.6153846153846, Blast_Score=81, Evalue=6e-16, Organism=Drosophila melanogaster, GI24649181, Length=212, Percent_Identity=29.7169811320755, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI24643142, Length=259, Percent_Identity=31.2741312741313, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI18859837, Length=193, Percent_Identity=31.0880829015544, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI21355631, Length=178, Percent_Identity=30.3370786516854, Blast_Score=67, Evalue=9e-12, Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI24581726, Length=221, Percent_Identity=27.1493212669683, Blast_Score=65, Evalue=5e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 29073; Mature: 29073
Theoretical pI: Translated: 6.03; Mature: 6.03
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMMMFGQLCDLSGLVALVTGAGGGERGGLGAAIARVLAQAGAQVAVNDLALEDAEATASM CCCHHHHHHCCCCHHHEEECCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH IRALGLVAEALPADVADPEQADQLVARVIERFGKIDILVNKAEYHSRAYRPDEIPTEEWQ HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHCCCCCCCCCHHHHH RSVAVNVHAPFYLSRAAVRDMRRRKFGRIINVSNIAAIRASVLHGTPYVATKEALYGFTR CEEEEEECCCHHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHH HLATEVAQHGITVNAILPGFVLTPKLAALWPDERIARLAPTIPALRAGTPEEIASLVVYL HHHHHHHHCCCEEEEECCCHHHCCHHHHHCCHHHHHHHCCCCCHHCCCCHHHHHHHHHHH ASPEAGYLTGAAIPIDGAVSIVPGGRMDPDNCFV CCCCCCCEECCCCCCCCCEEECCCCCCCCCCCCC >Mature Secondary Structure MMMMFGQLCDLSGLVALVTGAGGGERGGLGAAIARVLAQAGAQVAVNDLALEDAEATASM CCCHHHHHHCCCCHHHEEECCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH IRALGLVAEALPADVADPEQADQLVARVIERFGKIDILVNKAEYHSRAYRPDEIPTEEWQ HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHCCCCCCCCCHHHHH RSVAVNVHAPFYLSRAAVRDMRRRKFGRIINVSNIAAIRASVLHGTPYVATKEALYGFTR CEEEEEECCCHHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHH HLATEVAQHGITVNAILPGFVLTPKLAALWPDERIARLAPTIPALRAGTPEEIASLVVYL HHHHHHHHCCCEEEEECCCHHHCCHHHHHCCHHHHHHHCCCCCHHCCCCHHHHHHHHHHH ASPEAGYLTGAAIPIDGAVSIVPGGRMDPDNCFV CCCCCCCEECCCCCCCCCEEECCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10360571 [H]