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The map label for this gene is alr [H]

Identifier: 221635562

GI number: 221635562

Start: 146373

End: 147674

Strand: Reverse

Name: alr [H]

Synonym: trd_A0156

Alternate gene names: 221635562

Gene position: 147674-146373 (Counterclockwise)

Preceding gene: 221635565

Following gene: 221635561

Centisome position: 16.09

GC content: 68.89

Gene sequence:

>1302_bases
ATGGGAACGCAACGCGACCCCGGTCTCGGGGATCCCAATCAGCACGATGCCTCCGCTCTCCCCGCGGCGACCGAGCAGGT
CGACTGGCCCACGCGACTGTCCTGTGCACGAGCCGGGCTCCATGCGATCATCGACCTGGACCAGCTGGCGACGAATGCCC
GGACGCTAGTCCGCTTTCTCCCGCCCGATGTCGAGCTCCTCGCCGTCCTCAAGGCGAATGCCTACGGCCACGGACTCGTC
CCCAGCGCGCTCGCCGCGCTGGCGGGAGGCGCACGCTGGCTCGGCGTCGCGCGCATCGAGGAAGGTCTACTGCTCCGGCA
GGCCGGTCTCACTGCACCCGTCATCGTGCTGGGTCCCCCCAACCATGCACGCCTGCGCGCAGCGGTCGCGGCTGACCTCA
CCCTGGCGGTCGGCTCTCTGGCCGACGTCGAGGCAGTCCGGTCAGCCGCCAGCGCGCTCGGTCGCCCAGCCCGTGTCCAC
CTCGAGGTCGATACCGGCATGCACCGGTTCGGTGCCACGCCTGACGAAGCAGTCGCGCTGGCCCGCGGGTTGGCATCCGA
CCCGCTTCTCTCCTTCGAAGGGATCTACACCCATTTCGCGACCGCCGATGCCCCGGATTGCCGGACACTCCGTCGCCAGA
TGGAGCGCTTCCGCGCCGTCCGCGAGCGGTTGCTGGCCGAAGGTATCCACCCGCCAGTCGTGCACCAGGCGAACAGTGCT
GCCACGCTGCGCGGCGCGCTCGGCGACCCCGATCTCCCCGGTCGGCGCGTGGTTCGGGTCGGTATCCTCTTCTATGGTCT
CACCCCCGACCCAGCGCTGCTGCTTCCACCCGGCATTCGACCAGCGCTCACGCTCCAGGCCCGGCTCGCCCGCTGCTTCG
TTGTCCACGCGGGCGAAGGGATCTCCTACGGACATACCTATGTCACCAAAGCGCTCACCCACTGTGGCCTGGTCCCCGTC
GGCTATGCGGATGGTCTTCCGCGGGCGCTCTCCAACCAGGGCTGGTTCCTCGTCCAGGGACAGCGCTGCCCGATCCTCGG
ACGGGTCTGCATGGATCAAACGACGATCTCGCTCGAGGCGGTCCCTCAGGCGGAAATCGGTACTACGGTCATCGTGCTCG
GTACCGGCGAGGACGGCGCGATGACCGCGTGGGACGCTGCGACGCTCAGCGGCACCATCGCCTACGAGATCCTCACCAGC
CTGGCGACCAGGATTCCGCGCCTCTACCAGCGCGGCGGAGAAATCGTCGGCCTCGCGGACGCCTTCGGTCTCGTCTGGCG
CGACAGGATGCGAGCGCGGTAG

Upstream 100 bases:

>100_bases
CGAGTCACCCTCCCCGACGTTCGGAAAAGACGAGCGCTCTCGTCTCTCCCCACCCGCTGCTGCTGGGGCATACTAGTCAA
CGGCCACTCCGGGGGAAGGG

Downstream 100 bases:

>100_bases
CATCGACTCGACAGTGCGGAACCGGCCCTGCCGCGGTGCCAGTGTGGACCGCCAGGGAGGAGAAAGCTGGCGATGCCCGA
GCGAGCGATCCGCATCCTCC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MGTQRDPGLGDPNQHDASALPAATEQVDWPTRLSCARAGLHAIIDLDQLATNARTLVRFLPPDVELLAVLKANAYGHGLV
PSALAALAGGARWLGVARIEEGLLLRQAGLTAPVIVLGPPNHARLRAAVAADLTLAVGSLADVEAVRSAASALGRPARVH
LEVDTGMHRFGATPDEAVALARGLASDPLLSFEGIYTHFATADAPDCRTLRRQMERFRAVRERLLAEGIHPPVVHQANSA
ATLRGALGDPDLPGRRVVRVGILFYGLTPDPALLLPPGIRPALTLQARLARCFVVHAGEGISYGHTYVTKALTHCGLVPV
GYADGLPRALSNQGWFLVQGQRCPILGRVCMDQTTISLEAVPQAEIGTTVIVLGTGEDGAMTAWDAATLSGTIAYEILTS
LATRIPRLYQRGGEIVGLADAFGLVWRDRMRAR

Sequences:

>Translated_433_residues
MGTQRDPGLGDPNQHDASALPAATEQVDWPTRLSCARAGLHAIIDLDQLATNARTLVRFLPPDVELLAVLKANAYGHGLV
PSALAALAGGARWLGVARIEEGLLLRQAGLTAPVIVLGPPNHARLRAAVAADLTLAVGSLADVEAVRSAASALGRPARVH
LEVDTGMHRFGATPDEAVALARGLASDPLLSFEGIYTHFATADAPDCRTLRRQMERFRAVRERLLAEGIHPPVVHQANSA
ATLRGALGDPDLPGRRVVRVGILFYGLTPDPALLLPPGIRPALTLQARLARCFVVHAGEGISYGHTYVTKALTHCGLVPV
GYADGLPRALSNQGWFLVQGQRCPILGRVCMDQTTISLEAVPQAEIGTTVIVLGTGEDGAMTAWDAATLSGTIAYEILTS
LATRIPRLYQRGGEIVGLADAFGLVWRDRMRAR
>Mature_432_residues
GTQRDPGLGDPNQHDASALPAATEQVDWPTRLSCARAGLHAIIDLDQLATNARTLVRFLPPDVELLAVLKANAYGHGLVP
SALAALAGGARWLGVARIEEGLLLRQAGLTAPVIVLGPPNHARLRAAVAADLTLAVGSLADVEAVRSAASALGRPARVHL
EVDTGMHRFGATPDEAVALARGLASDPLLSFEGIYTHFATADAPDCRTLRRQMERFRAVRERLLAEGIHPPVVHQANSAA
TLRGALGDPDLPGRRVVRVGILFYGLTPDPALLLPPGIRPALTLQARLARCFVVHAGEGISYGHTYVTKALTHCGLVPVG
YADGLPRALSNQGWFLVQGQRCPILGRVCMDQTTISLEAVPQAEIGTTVIVLGTGEDGAMTAWDAATLSGTIAYEILTSL
ATRIPRLYQRGGEIVGLADAFGLVWRDRMRAR

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1790487, Length=371, Percent_Identity=33.9622641509434, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787439, Length=372, Percent_Identity=31.989247311828, Blast_Score=141, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 45900; Mature: 45769

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00395 ALANINE_RACEMASE ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTQRDPGLGDPNQHDASALPAATEQVDWPTRLSCARAGLHAIIDLDQLATNARTLVRFL
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCHHHEEEHHHHHHHHHHHHHHC
PPDVELLAVLKANAYGHGLVPSALAALAGGARWLGVARIEEGLLLRQAGLTAPVIVLGPP
CCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHEEHHHHHCCHHEEECCCCCCEEEECCC
NHARLRAAVAADLTLAVGSLADVEAVRSAASALGRPARVHLEVDTGMHRFGATPDEAVAL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCHHHHHHH
ARGLASDPLLSFEGIYTHFATADAPDCRTLRRQMERFRAVRERLLAEGIHPPVVHQANSA
HHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
ATLRGALGDPDLPGRRVVRVGILFYGLTPDPALLLPPGIRPALTLQARLARCFVVHAGEG
CEEECCCCCCCCCCCCEEEEEEEEEECCCCCCEEECCCCCHHHHHHHHHHEEEEEECCCC
ISYGHTYVTKALTHCGLVPVGYADGLPRALSNQGWFLVQGQRCPILGRVCMDQTTISLEA
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHCCCEEEEEE
VPQAEIGTTVIVLGTGEDGAMTAWDAATLSGTIAYEILTSLATRIPRLYQRGGEIVGLAD
CCCCCCCCEEEEEECCCCCCEEEECHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
AFGLVWRDRMRAR
HHHHHHHHHHCCC
>Mature Secondary Structure 
GTQRDPGLGDPNQHDASALPAATEQVDWPTRLSCARAGLHAIIDLDQLATNARTLVRFL
CCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCHHHEEEHHHHHHHHHHHHHHC
PPDVELLAVLKANAYGHGLVPSALAALAGGARWLGVARIEEGLLLRQAGLTAPVIVLGPP
CCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHEEHHHHHCCHHEEECCCCCCEEEECCC
NHARLRAAVAADLTLAVGSLADVEAVRSAASALGRPARVHLEVDTGMHRFGATPDEAVAL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCHHHHHHH
ARGLASDPLLSFEGIYTHFATADAPDCRTLRRQMERFRAVRERLLAEGIHPPVVHQANSA
HHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
ATLRGALGDPDLPGRRVVRVGILFYGLTPDPALLLPPGIRPALTLQARLARCFVVHAGEG
CEEECCCCCCCCCCCCEEEEEEEEEECCCCCCEEECCCCCHHHHHHHHHHEEEEEECCCC
ISYGHTYVTKALTHCGLVPVGYADGLPRALSNQGWFLVQGQRCPILGRVCMDQTTISLEA
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHCCCEEEEEE
VPQAEIGTTVIVLGTGEDGAMTAWDAATLSGTIAYEILTSLATRIPRLYQRGGEIVGLAD
CCCCCCCCEEEEEECCCCCCEEEECHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
AFGLVWRDRMRAR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA