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The map label for this gene is ilvG [H]

Identifier: 221635565

GI number: 221635565

Start: 149598

End: 151214

Strand: Reverse

Name: ilvG [H]

Synonym: trd_A0158

Alternate gene names: 221635565

Gene position: 151214-149598 (Counterclockwise)

Preceding gene: 221635567

Following gene: 221635562

Centisome position: 16.48

GC content: 70.62

Gene sequence:

>1617_bases
ATGGCGACTGTCGCCGAAGTCATCGCCCAGGAACTGCGAACAGCTGGGGTGGACCGCGCCTTCGGGCTTCCCGGTGGGGA
GGTGCTGGCGCTCATCGACGCGCTGCGGCGAGCGGGGATCGTCTTCACCCTCTGCCGGCATGAGGCAGTGGCCGGCATCG
CCGCCGGCGTCTACGGCAAGCTCCGCCGCACCGCTGGCGTCGCGGTCGCCACCCTGGGACCCGGCGCGGCCAACTTCCTG
CTCGCCGTCAGCAATGCCTGGCTCGACCGCGAACCGCTCCTCGCCATCACCGCCGACCTGCCCGCCAGCTGGCCACCCAG
TCACACCCACCAGCGACTCCCCCTCCACGACATCTACCGTCCTGTCACCAAGCATGTGGAGGCGGTCACGCCGCTCGACC
CGCACCGCCCGGTCCGGCGTGCCCTCATCGCCTGTACGCGCGAGCCACTGGGGCCGAGTTACCTCACTCTTTCCGCCGAG
GATGCCGTGCGACCAGCCTGCATCCTGCACGAGGAGTCGCTCGCCCTCCGACCGGCGGCGACAGCGCAGGACGCCCGGGT
CGCTGCCGAGGAATTGGCGCGTCGCCTGGCCGAGGCCGAGCGACCACTCGTCGTGATCGGTCTGGGCGTGCGGCCGGAAA
ACGCGCCGGGCCTGCGGCGCTGGCTGGCCGCGTGGCATCTCCCGGTCGCCGTGACGCCCAAGGCGAAGGGGCTGGTGGAC
GAACGCGACCCGGCCATCGATTTCGTCGGCGTCGTCGGTGGGATGGCGATCGACGGCCTCATGGTCGAAGCCGTCCAGCA
GGCCGACCTCCTCGTCGGGTTCGGCTTCGATCCGGTGGAAGTGGACAAGACCTGGCACGCCCACCGTCCGGTGCTCTGGG
TCCTGGAATCGGCCCAGGCGACAGGCCTGCTCCCGCGACGCGACCTCCTCCTGGTCGACCACCATGCGCTCCTCGCCGCG
CTCGGCGAACTGGCCCCGCCGCGCCGCTGGGAGCGCCCGTTTCAGGAGGTCCAGGCGGAGCGGGCCGCTATCGCGGCAGG
GAAGAGCCGCGCACCAGCTCAGGGACTCGCCCCAGTGCGCATCGTCGAGGTGCTGGCCGCAGTCCTCCCGGCCGAGACGA
TCGTGACGACTGACGTGGGGTCGCACAAGTATCTCTTCGGGCAGTTCTGGCCGAGCCGTCACCCGGAGACGTTCTGGATG
TCGAACGGCTTGTCCGGCATGGGGTACGGACTCGCTGCGGCGATCGGGGCCAAGCTGGCGCGGCCGGCTGCGCCGGTGCT
GGCGGTACTCGGCGACGGCGGATTCTCCATGGTCTGCCAGGAACTGGAGACCGCCCGGCGCATCGGTGCACCAGTCATCG
TCCTAATCATCGCCGATCGCTCCTACTCGCTGATCCGCATCGGCCAGGAAAACCGCGGTCTGCCACGCTACGGCGTCGAC
TTCGAGCCGATCGACAGCGTGCTCGTCGCGCAGGCCTGCGGCTGCGCTGGCACGGTGGCCCGGACTCCCGACGAACTGGC
CGCGGCCGCCCGCCAGGCGCTCGCCGCCAACGAGGCCGGGTTGCCGTTCGTCATCGAGGTACCGCTCGATCCGGACGCCT
ATCGACCGATCGTCTGA

Upstream 100 bases:

>100_bases
GGTGACGAGCGAGGCAGCCCGGATCCCGTCCCATCGCTTGCTCTCCGGCATCCCCATCCCCTACACTGCCGCCGACCGGA
CCGCGGGAAGGAGCGGAGCG

Downstream 100 bases:

>100_bases
GCGCGCACTCGCCAGCAGGGTCGCGACCAGGCATCGAGCTCGCGCCGCTTCAGTTGCGCGCTCAGGCCGAAGCGCCGGGC
CTCCCGACACACCCGGGCTT

Product: acetolactate synthase

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MATVAEVIAQELRTAGVDRAFGLPGGEVLALIDALRRAGIVFTLCRHEAVAGIAAGVYGKLRRTAGVAVATLGPGAANFL
LAVSNAWLDREPLLAITADLPASWPPSHTHQRLPLHDIYRPVTKHVEAVTPLDPHRPVRRALIACTREPLGPSYLTLSAE
DAVRPACILHEESLALRPAATAQDARVAAEELARRLAEAERPLVVIGLGVRPENAPGLRRWLAAWHLPVAVTPKAKGLVD
ERDPAIDFVGVVGGMAIDGLMVEAVQQADLLVGFGFDPVEVDKTWHAHRPVLWVLESAQATGLLPRRDLLLVDHHALLAA
LGELAPPRRWERPFQEVQAERAAIAAGKSRAPAQGLAPVRIVEVLAAVLPAETIVTTDVGSHKYLFGQFWPSRHPETFWM
SNGLSGMGYGLAAAIGAKLARPAAPVLAVLGDGGFSMVCQELETARRIGAPVIVLIIADRSYSLIRIGQENRGLPRYGVD
FEPIDSVLVAQACGCAGTVARTPDELAAAARQALAANEAGLPFVIEVPLDPDAYRPIV

Sequences:

>Translated_538_residues
MATVAEVIAQELRTAGVDRAFGLPGGEVLALIDALRRAGIVFTLCRHEAVAGIAAGVYGKLRRTAGVAVATLGPGAANFL
LAVSNAWLDREPLLAITADLPASWPPSHTHQRLPLHDIYRPVTKHVEAVTPLDPHRPVRRALIACTREPLGPSYLTLSAE
DAVRPACILHEESLALRPAATAQDARVAAEELARRLAEAERPLVVIGLGVRPENAPGLRRWLAAWHLPVAVTPKAKGLVD
ERDPAIDFVGVVGGMAIDGLMVEAVQQADLLVGFGFDPVEVDKTWHAHRPVLWVLESAQATGLLPRRDLLLVDHHALLAA
LGELAPPRRWERPFQEVQAERAAIAAGKSRAPAQGLAPVRIVEVLAAVLPAETIVTTDVGSHKYLFGQFWPSRHPETFWM
SNGLSGMGYGLAAAIGAKLARPAAPVLAVLGDGGFSMVCQELETARRIGAPVIVLIIADRSYSLIRIGQENRGLPRYGVD
FEPIDSVLVAQACGCAGTVARTPDELAAAARQALAANEAGLPFVIEVPLDPDAYRPIV
>Mature_537_residues
ATVAEVIAQELRTAGVDRAFGLPGGEVLALIDALRRAGIVFTLCRHEAVAGIAAGVYGKLRRTAGVAVATLGPGAANFLL
AVSNAWLDREPLLAITADLPASWPPSHTHQRLPLHDIYRPVTKHVEAVTPLDPHRPVRRALIACTREPLGPSYLTLSAED
AVRPACILHEESLALRPAATAQDARVAAEELARRLAEAERPLVVIGLGVRPENAPGLRRWLAAWHLPVAVTPKAKGLVDE
RDPAIDFVGVVGGMAIDGLMVEAVQQADLLVGFGFDPVEVDKTWHAHRPVLWVLESAQATGLLPRRDLLLVDHHALLAAL
GELAPPRRWERPFQEVQAERAAIAAGKSRAPAQGLAPVRIVEVLAAVLPAETIVTTDVGSHKYLFGQFWPSRHPETFWMS
NGLSGMGYGLAAAIGAKLARPAAPVLAVLGDGGFSMVCQELETARRIGAPVIVLIIADRSYSLIRIGQENRGLPRYGVDF
EPIDSVLVAQACGCAGTVARTPDELAAAARQALAANEAGLPFVIEVPLDPDAYRPIV

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=580, Percent_Identity=24.8275862068966, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI21361361, Length=522, Percent_Identity=25.095785440613, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI87081685, Length=554, Percent_Identity=26.8953068592058, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1790104, Length=480, Percent_Identity=29.375, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=26.3345195729537, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787096, Length=535, Percent_Identity=22.4299065420561, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788716, Length=583, Percent_Identity=22.8130360205832, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542570, Length=517, Percent_Identity=24.1779497098646, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323755, Length=565, Percent_Identity=27.0796460176991, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320816, Length=478, Percent_Identity=23.2217573221757, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922626, Length=502, Percent_Identity=25.0996015936255, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 57342; Mature: 57211

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVAEVIAQELRTAGVDRAFGLPGGEVLALIDALRRAGIVFTLCRHEAVAGIAAGVYGK
CCHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHH
LRRTAGVAVATLGPGAANFLLAVSNAWLDREPLLAITADLPASWPPSHTHQRLPLHDIYR
HHHHCCEEEEECCCCHHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
PVTKHVEAVTPLDPHRPVRRALIACTREPLGPSYLTLSAEDAVRPACILHEESLALRPAA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCEEEEECCCCCCCCCC
TAQDARVAAEELARRLAEAERPLVVIGLGVRPENAPGLRRWLAAWHLPVAVTPKAKGLVD
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCC
ERDPAIDFVGVVGGMAIDGLMVEAVQQADLLVGFGFDPVEVDKTWHAHRPVLWVLESAQA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEECCCCCCCCCCEEEEEECCHH
TGLLPRRDLLLVDHHALLAALGELAPPRRWERPFQEVQAERAAIAAGKSRAPAQGLAPVR
CCCCCCCCEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
IVEVLAAVLPAETIVTTDVGSHKYLFGQFWPSRHPETFWMSNGLSGMGYGLAAAIGAKLA
HHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHC
RPAAPVLAVLGDGGFSMVCQELETARRIGAPVIVLIIADRSYSLIRIGQENRGLPRYGVD
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCC
FEPIDSVLVAQACGCAGTVARTPDELAAAARQALAANEAGLPFVIEVPLDPDAYRPIV
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ATVAEVIAQELRTAGVDRAFGLPGGEVLALIDALRRAGIVFTLCRHEAVAGIAAGVYGK
CHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHH
LRRTAGVAVATLGPGAANFLLAVSNAWLDREPLLAITADLPASWPPSHTHQRLPLHDIYR
HHHHCCEEEEECCCCHHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
PVTKHVEAVTPLDPHRPVRRALIACTREPLGPSYLTLSAEDAVRPACILHEESLALRPAA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCEEEEECCCCCCCCCC
TAQDARVAAEELARRLAEAERPLVVIGLGVRPENAPGLRRWLAAWHLPVAVTPKAKGLVD
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCC
ERDPAIDFVGVVGGMAIDGLMVEAVQQADLLVGFGFDPVEVDKTWHAHRPVLWVLESAQA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEECCCCCCCCCCEEEEEECCHH
TGLLPRRDLLLVDHHALLAALGELAPPRRWERPFQEVQAERAAIAAGKSRAPAQGLAPVR
CCCCCCCCEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
IVEVLAAVLPAETIVTTDVGSHKYLFGQFWPSRHPETFWMSNGLSGMGYGLAAAIGAKLA
HHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHC
RPAAPVLAVLGDGGFSMVCQELETARRIGAPVIVLIIADRSYSLIRIGQENRGLPRYGVD
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCC
FEPIDSVLVAQACGCAGTVARTPDELAAAARQALAANEAGLPFVIEVPLDPDAYRPIV
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]