Click here to switch to the map view.

The map label for this gene is cymR [H]

Identifier: 221633611

GI number: 221633611

Start: 1629847

End: 1630287

Strand: Reverse

Name: cymR [H]

Synonym: trd_1635

Alternate gene names: 221633611

Gene position: 1630287-1629847 (Counterclockwise)

Preceding gene: 221633619

Following gene: 221633610

Centisome position: 81.39

GC content: 68.03

Gene sequence:

>441_bases
ATGAAGGTTTCGACGCGCGGCGAGTACGGATTGCGAGCGATGGTCTCGCTGGCCCGCATGTACGGGCGCGGCCCCATGCC
GTTGAGCGTCATCGCGCAGGACTCGGCCGTGCCGCTGGCGTACCTGGAGCAGCTCATGCTGCCGTTGCGCCGGGCTGGGC
TCGTCGTTTCCACCCGCGGCGCCCATGGGGGCTACGAGCTGGCTCGCCCACCCGAGCAGGTGAAGGTCGGCGAGATCTAC
CGCGTGATGGAAGGGCCGATCGCTCCCATGGACTGCGTGCGCGAGGACGCCGACGAGGATATCTGCCCGATGATCGACGG
TTGCGCGACGCGGATCGTCTGGCTCAAGCTGCGCGACAGTATCGTCGAGGTCCTCGACTCGACGACGCTGGCCGATCTCA
TCAGTCACGCGCCGCGTCCACGCGCCGAGCAGCCGGTCTGA

Upstream 100 bases:

>100_bases
CCGAGCGATGCGGTAAGGTAAGAGCGCGGGGCGAGAATCATTCTCAGCTGCGAGGAAGTCGCAGGTCGTCTCGCCTGCCT
CCAGCGATAGGACACGAGCC

Downstream 100 bases:

>100_bases
TGCCGGACGCAGTCGTCGATACGGGGAGGGATGCGTGAACCGAACCGAAATCTACCTCGACCATGCGGCGACCACCCCGG
TCGATCCCCGCGTGCTCGAG

Product: Transcriptional regulator superfamily

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKVSTRGEYGLRAMVSLARMYGRGPMPLSVIAQDSAVPLAYLEQLMLPLRRAGLVVSTRGAHGGYELARPPEQVKVGEIY
RVMEGPIAPMDCVREDADEDICPMIDGCATRIVWLKLRDSIVEVLDSTTLADLISHAPRPRAEQPV

Sequences:

>Translated_146_residues
MKVSTRGEYGLRAMVSLARMYGRGPMPLSVIAQDSAVPLAYLEQLMLPLRRAGLVVSTRGAHGGYELARPPEQVKVGEIY
RVMEGPIAPMDCVREDADEDICPMIDGCATRIVWLKLRDSIVEVLDSTTLADLISHAPRPRAEQPV
>Mature_146_residues
MKVSTRGEYGLRAMVSLARMYGRGPMPLSVIAQDSAVPLAYLEQLMLPLRRAGLVVSTRGAHGGYELARPPEQVKVGEIY
RVMEGPIAPMDCVREDADEDICPMIDGCATRIVWLKLRDSIVEVLDSTTLADLISHAPRPRAEQPV

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790621, Length=134, Percent_Identity=27.6119402985075, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 16045; Mature: 16045

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSTRGEYGLRAMVSLARMYGRGPMPLSVIAQDSAVPLAYLEQLMLPLRRAGLVVSTRG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCEEEEECC
AHGGYELARPPEQVKVGEIYRVMEGPIAPMDCVREDADEDICPMIDGCATRIVWLKLRDS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IVEVLDSTTLADLISHAPRPRAEQPV
HHHHHCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKVSTRGEYGLRAMVSLARMYGRGPMPLSVIAQDSAVPLAYLEQLMLPLRRAGLVVSTRG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCEEEEECC
AHGGYELARPPEQVKVGEIYRVMEGPIAPMDCVREDADEDICPMIDGCATRIVWLKLRDS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IVEVLDSTTLADLISHAPRPRAEQPV
HHHHHCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]