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The map label for this gene is iscS [H]

Identifier: 221633610

GI number: 221633610

Start: 1628640

End: 1629812

Strand: Reverse

Name: iscS [H]

Synonym: trd_1634

Alternate gene names: 221633610

Gene position: 1629812-1628640 (Counterclockwise)

Preceding gene: 221633611

Following gene: 221633601

Centisome position: 81.37

GC content: 66.24

Gene sequence:

>1173_bases
GTGAACCGAACCGAAATCTACCTCGACCATGCGGCGACCACCCCGGTCGATCCCCGCGTGCTCGAGGCGATGCTCCCCTT
CTTTACGGAACGATTCGGGAATCCCTCGAGCATCTACGCGGCGGGACGCGAGGCCCGCGCCGCGCTCGACCAGGCGCGTG
CCCGCATCGCCCGTCTCCTCAACTGCCAGGCGCGCGAGATCGTCTTCACCAGCGGCGGCACCGAGAGCGATAACCTCGCT
GTCAAAGGTGTCGCATTCTGGCACCTGGTGAACGGGCGCGGTCGGCACATCGTGACCACCGCCTTCGAGCACCATGCTGT
TCTCCACAGCGCTGAGTACCTCGAGCGCTTCGGCTTCCACGTCACCTACGTCGCACCGGACGCTGATGGGATCGTCCAGC
CGGAAGCGATCGAGGCAGCGCTCCGTCCGGATACCATTCTGGTTTCCGTGATGTACGCCAACAACGAGATCGGGACGATC
CAGCCGATCCGCGAGATCGCCCACTTGTGTCGCGAGCGCGGCATCACCGTCCACACCGATGCTGTCCAGGCAGCTGGCAC
CTTGCCGCTCGATGTCGAGGAGCTCGGCGTCGACCTGCTTTCCATCAGTGCCCATAAGTTCTACGGGCCCAAGGGGGTCG
GGTTGCTCTACGTGCGCAGCGGGACGCCCATCCTCTGGCAACAGCACGGCGGTGCGCAGGAGAGCAACCGGCGCGCGGGC
ACGGAGAACGTCCCCGGTATCGTCGGTATGGCGCGAGCGCTCGAGCTAGCGTACGAGGAGCTCGACGAGCGCAACGCGCA
TGTCCAGGCGTTGCGCGACCGGCTGATCGACGGGATTCTCCAGCGCATCCCGGACAGTCGACTGAACGGGCATCGCCACC
AGCGGCTGCCCAACAACGTGAACGTGACCTTCGCGGGTGTCGATGGCGAGACGTTGCTCTTGAACCTCGACCTGCACGGG
ATCGCTGCCTCCTCTGGATCAGCCTGCACGACCGGTTCCACCGAGCCGAGCCACGTCTTGCTCGCGATCGGCGCGACACC
CGAGCAGGCCCGCAGCAGCGTGCGCCTCACGCTCGGCAAGGACAATACGGCGCGCGAGATCGAGCGGACGCTCGACGTGC
TCGAGGAAACGGTCGCCCGGCTGCGCAAGCTGGCTGGCGCACGGAGCCGCTAG

Upstream 100 bases:

>100_bases
GACTCGACGACGCTGGCCGATCTCATCAGTCACGCGCCGCGTCCACGCGCCGAGCAGCCGGTCTGATGCCGGACGCAGTC
GTCGATACGGGGAGGGATGC

Downstream 100 bases:

>100_bases
TTCCTGGGTATCGGAATTCGTCCCCCACGCGGCGGGGATGTGCTGCGTCCCATCCTGGGACGACGTTCCCCCTACCGTCT
CTGCCCGGCGACGCCGCCGT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNRTEIYLDHAATTPVDPRVLEAMLPFFTERFGNPSSIYAAGREARAALDQARARIARLLNCQAREIVFTSGGTESDNLA
VKGVAFWHLVNGRGRHIVTTAFEHHAVLHSAEYLERFGFHVTYVAPDADGIVQPEAIEAALRPDTILVSVMYANNEIGTI
QPIREIAHLCRERGITVHTDAVQAAGTLPLDVEELGVDLLSISAHKFYGPKGVGLLYVRSGTPILWQQHGGAQESNRRAG
TENVPGIVGMARALELAYEELDERNAHVQALRDRLIDGILQRIPDSRLNGHRHQRLPNNVNVTFAGVDGETLLLNLDLHG
IAASSGSACTTGSTEPSHVLLAIGATPEQARSSVRLTLGKDNTAREIERTLDVLEETVARLRKLAGARSR

Sequences:

>Translated_390_residues
MNRTEIYLDHAATTPVDPRVLEAMLPFFTERFGNPSSIYAAGREARAALDQARARIARLLNCQAREIVFTSGGTESDNLA
VKGVAFWHLVNGRGRHIVTTAFEHHAVLHSAEYLERFGFHVTYVAPDADGIVQPEAIEAALRPDTILVSVMYANNEIGTI
QPIREIAHLCRERGITVHTDAVQAAGTLPLDVEELGVDLLSISAHKFYGPKGVGLLYVRSGTPILWQQHGGAQESNRRAG
TENVPGIVGMARALELAYEELDERNAHVQALRDRLIDGILQRIPDSRLNGHRHQRLPNNVNVTFAGVDGETLLLNLDLHG
IAASSGSACTTGSTEPSHVLLAIGATPEQARSSVRLTLGKDNTAREIERTLDVLEETVARLRKLAGARSR
>Mature_390_residues
MNRTEIYLDHAATTPVDPRVLEAMLPFFTERFGNPSSIYAAGREARAALDQARARIARLLNCQAREIVFTSGGTESDNLA
VKGVAFWHLVNGRGRHIVTTAFEHHAVLHSAEYLERFGFHVTYVAPDADGIVQPEAIEAALRPDTILVSVMYANNEIGTI
QPIREIAHLCRERGITVHTDAVQAAGTLPLDVEELGVDLLSISAHKFYGPKGVGLLYVRSGTPILWQQHGGAQESNRRAG
TENVPGIVGMARALELAYEELDERNAHVQALRDRLIDGILQRIPDSRLNGHRHQRLPNNVNVTFAGVDGETLLLNLDLHG
IAASSGSACTTGSTEPSHVLLAIGATPEQARSSVRLTLGKDNTAREIERTLDVLEETVARLRKLAGARSR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=383, Percent_Identity=45.6919060052219, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI156713448, Length=418, Percent_Identity=36.8421052631579, Blast_Score=236, Evalue=4e-62,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=49.0909090909091, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=27.8325123152709, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789175, Length=402, Percent_Identity=26.1194029850746, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=383, Percent_Identity=46.7362924281984, Blast_Score=337, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17533177, Length=323, Percent_Identity=34.3653250773994, Blast_Score=165, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319831, Length=386, Percent_Identity=45.3367875647668, Blast_Score=325, Evalue=6e-90,
Organism=Drosophila melanogaster, GI20129463, Length=383, Percent_Identity=45.6919060052219, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42533; Mature: 42533

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTEIYLDHAATTPVDPRVLEAMLPFFTERFGNPSSIYAAGREARAALDQARARIARLL
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
NCQAREIVFTSGGTESDNLAVKGVAFWHLVNGRGRHIVTTAFEHHAVLHSAEYLERFGFH
CCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCCE
VTYVAPDADGIVQPEAIEAALRPDTILVSVMYANNEIGTIQPIREIAHLCRERGITVHTD
EEEECCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEH
AVQAAGTLPLDVEELGVDLLSISAHKFYGPKGVGLLYVRSGTPILWQQHGGAQESNRRAG
HHHHCCCCCCCHHHHCCCCEEECHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCC
TENVPGIVGMARALELAYEELDERNAHVQALRDRLIDGILQRIPDSRLNGHRHQRLPNNV
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCC
NVTFAGVDGETLLLNLDLHGIAASSGSACTTGSTEPSHVLLAIGATPEQARSSVRLTLGK
EEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHCCCEEEEECC
DNTAREIERTLDVLEETVARLRKLAGARSR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRTEIYLDHAATTPVDPRVLEAMLPFFTERFGNPSSIYAAGREARAALDQARARIARLL
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
NCQAREIVFTSGGTESDNLAVKGVAFWHLVNGRGRHIVTTAFEHHAVLHSAEYLERFGFH
CCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCCE
VTYVAPDADGIVQPEAIEAALRPDTILVSVMYANNEIGTIQPIREIAHLCRERGITVHTD
EEEECCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEH
AVQAAGTLPLDVEELGVDLLSISAHKFYGPKGVGLLYVRSGTPILWQQHGGAQESNRRAG
HHHHCCCCCCCHHHHCCCCEEECHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCC
TENVPGIVGMARALELAYEELDERNAHVQALRDRLIDGILQRIPDSRLNGHRHQRLPNNV
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCC
NVTFAGVDGETLLLNLDLHGIAASSGSACTTGSTEPSHVLLAIGATPEQARSSVRLTLGK
EEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHCCCEEEEECC
DNTAREIERTLDVLEETVARLRKLAGARSR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA