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The map label for this gene is accC [H]

Identifier: 221633596

GI number: 221633596

Start: 1614706

End: 1616058

Strand: Reverse

Name: accC [H]

Synonym: trd_1620

Alternate gene names: 221633596

Gene position: 1616058-1614706 (Counterclockwise)

Preceding gene: 221633597

Following gene: 221633595

Centisome position: 80.68

GC content: 66.59

Gene sequence:

>1353_bases
ATGATCCGCAAGGTCCTCATCGCCAACCGAGGCGAGATCGCGCTGCGCGTCCTCCGCGCGTGCCGGGAACTGGGTGTCCC
GGCCGTCGTCGCCTACTCGGAGGCCGACCGAGAATCGTTGCCGGTGCGTTTGGCTGACGAGGCGATTTGTATCGGGCCGG
CACCAGCTGAGCGGAGCTACAACCATATTCCTGCCATCATCAGTGCGGCGGTCGTCACCGGCTGCGATGCCCTCCACCCC
GGTTACGGGTTTTTGGCCGAGAACGCACTCCTGGCCGAGATCTGCGAAGAATGCGGGATCACTTTCATCGGACCCCGACC
GCAGACGCTCCGTGCGCTCGGCGACAAGGCAGAAGCGCGTCGGCTCATGCAGCGCGCCGGGCTCCCGATCGTCCCAGGGA
GTGAGACGCCCGTTCGCGATGCGAGCGAGGCCCGGCGCATCGCGCGCAAGCTGGGCTATCCCGTTCTCGTCAAGGCCGCA
GCCGGTGGCGGTGGACGCGGCATGCGGATCGTGCGGGAGGAACGCGAACTCGCCACGGCTCTGCAAGTCGCTCAGCAGGA
AGCGCAGGCAGCCTTCGGCGATCCCTCCGTCTATCTGGAACGCTACCTGGAGCGGCCACGGCACGTCGAGGTGCAGATCT
TGGCTGATCAGCACGGGAACATCGTCGCCGTCGGTGAGCGCGACTGCTCCATCCAGCGCCGCTACCAGAAACTGATCGAA
GAGGCCCCCGCACCCGATTTGTCAGCGAGGGTGCGCGACGCGCTCCATGAGGCCGCTGTTCGTGGTGCACGGGCGGTCGG
TTACGTCGGTGCTGGCACCTTCGAGTTCCTGGTCGATCGGGAAGGCCATTTCTACTTCACCGAAGCCAATGCGCGTCTCC
AGGTCGAGCATCCGGTCACCGAAGCCGTGACCGGCCTCGATCTCGTCCAGTGGCAGTTGGCTATCGCGGCCGGCGAGCGC
CTCGCGCTGCGCGAGCGCGATCTTGCGCCCCGCGGGCACGCCATCGAGGTGCGCGTCACGGCCGAGGATCCCGACCGTGA
CTTCGCGCCGCGTCCTGGCCGCATCGAGCAATTGGTCTGGCCAGGTGGACCCGGAATCCGCGTCGACTCGCATGCCTATG
CTGGCTACGTCGTCCCGCCGCACTACGACTCGCTTTTGGGTAAGGTGATCGCCTGGGGGCTCGATCGGGCACAAGCGATC
GAGCGACTCGACCGCGCTCTCCGCGAAACGATCATCGACGGTGTGCCCACCCCGATCCCGCTTCTCCGTCGCATCCTGCA
GCACCCGGATTTTCGGGCTAGCCGGCACACGACGACCTTCCTGGCCGAGTACCTCGCCAGCCAGCAGAGCTGA

Upstream 100 bases:

>100_bases
TCGCCGAGGCGATCGCCTTCCTCGTCTCGCCGGGGGCACGGTACATCACGGGAGCTGTCCTGGCTGTCGATGGCGGGCTC
ACCATGGCATCGTGAGCGGC

Downstream 100 bases:

>100_bases
GCAGGGTACAATCGATCCGTGGGGGCTGCTCGGCAGTCCTCTCGATGGCGCTACGGTTCCGCTCGCCGCGAGGATTCCAT
GGATTCGGTTCCGATCGCGA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIRKVLIANRGEIALRVLRACRELGVPAVVAYSEADRESLPVRLADEAICIGPAPAERSYNHIPAIISAAVVTGCDALHP
GYGFLAENALLAEICEECGITFIGPRPQTLRALGDKAEARRLMQRAGLPIVPGSETPVRDASEARRIARKLGYPVLVKAA
AGGGGRGMRIVREERELATALQVAQQEAQAAFGDPSVYLERYLERPRHVEVQILADQHGNIVAVGERDCSIQRRYQKLIE
EAPAPDLSARVRDALHEAAVRGARAVGYVGAGTFEFLVDREGHFYFTEANARLQVEHPVTEAVTGLDLVQWQLAIAAGER
LALRERDLAPRGHAIEVRVTAEDPDRDFAPRPGRIEQLVWPGGPGIRVDSHAYAGYVVPPHYDSLLGKVIAWGLDRAQAI
ERLDRALRETIIDGVPTPIPLLRRILQHPDFRASRHTTTFLAEYLASQQS

Sequences:

>Translated_450_residues
MIRKVLIANRGEIALRVLRACRELGVPAVVAYSEADRESLPVRLADEAICIGPAPAERSYNHIPAIISAAVVTGCDALHP
GYGFLAENALLAEICEECGITFIGPRPQTLRALGDKAEARRLMQRAGLPIVPGSETPVRDASEARRIARKLGYPVLVKAA
AGGGGRGMRIVREERELATALQVAQQEAQAAFGDPSVYLERYLERPRHVEVQILADQHGNIVAVGERDCSIQRRYQKLIE
EAPAPDLSARVRDALHEAAVRGARAVGYVGAGTFEFLVDREGHFYFTEANARLQVEHPVTEAVTGLDLVQWQLAIAAGER
LALRERDLAPRGHAIEVRVTAEDPDRDFAPRPGRIEQLVWPGGPGIRVDSHAYAGYVVPPHYDSLLGKVIAWGLDRAQAI
ERLDRALRETIIDGVPTPIPLLRRILQHPDFRASRHTTTFLAEYLASQQS
>Mature_450_residues
MIRKVLIANRGEIALRVLRACRELGVPAVVAYSEADRESLPVRLADEAICIGPAPAERSYNHIPAIISAAVVTGCDALHP
GYGFLAENALLAEICEECGITFIGPRPQTLRALGDKAEARRLMQRAGLPIVPGSETPVRDASEARRIARKLGYPVLVKAA
AGGGGRGMRIVREERELATALQVAQQEAQAAFGDPSVYLERYLERPRHVEVQILADQHGNIVAVGERDCSIQRRYQKLIE
EAPAPDLSARVRDALHEAAVRGARAVGYVGAGTFEFLVDREGHFYFTEANARLQVEHPVTEAVTGLDLVQWQLAIAAGER
LALRERDLAPRGHAIEVRVTAEDPDRDFAPRPGRIEQLVWPGGPGIRVDSHAYAGYVVPPHYDSLLGKVIAWGLDRAQAI
ERLDRALRETIIDGVPTPIPLLRRILQHPDFRASRHTTTFLAEYLASQQS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=47.972972972973, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=48.993288590604, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=48.993288590604, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=48.993288590604, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=46.1538461538462, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=46.1538461538462, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=46.1538461538462, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=32.8094302554028, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=32.8094302554028, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=32.8094302554028, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=32.8094302554028, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=32.8094302554028, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=31.1154598825832, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1789654, Length=451, Percent_Identity=52.1064301552106, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=47.5225225225225, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=48.4375, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=43.2126696832579, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=499, Percent_Identity=31.062124248497, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=30.1556420233463, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=30.1556420233463, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193204318, Length=236, Percent_Identity=26.271186440678, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=441, Percent_Identity=42.6303854875283, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.0892857142857, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.9821428571429, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=524, Percent_Identity=30.7251908396947, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=31.8965517241379, Blast_Score=222, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=46.4125560538117, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=49.1071428571429, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=49.1071428571429, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=49.1071428571429, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=49.1071428571429, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=49.1071428571429, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=49.1071428571429, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=49.1071428571429, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=49.1071428571429, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=49.1071428571429, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=49.1071428571429, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=45.8128078817734, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=32.4701195219124, Blast_Score=238, Evalue=9e-63,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=32.4701195219124, Blast_Score=237, Evalue=9e-63,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=32.4701195219124, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=32.4701195219124, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49351; Mature: 49351

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKVLIANRGEIALRVLRACRELGVPAVVAYSEADRESLPVRLADEAICIGPAPAERSY
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCEEEECCCCCCCCC
NHIPAIISAAVVTGCDALHPGYGFLAENALLAEICEECGITFIGPRPQTLRALGDKAEAR
CCHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCHHHHH
RLMQRAGLPIVPGSETPVRDASEARRIARKLGYPVLVKAAAGGGGRGMRIVREERELATA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LQVAQQEAQAAFGDPSVYLERYLERPRHVEVQILADQHGNIVAVGERDCSIQRRYQKLIE
HHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPAPDLSARVRDALHEAAVRGARAVGYVGAGTFEFLVDREGHFYFTEANARLQVEHPVT
HCCCCCHHHHHHHHHHHHHHHCCHHEEEECCCCEEEEEECCCCEEEEECCCEEEECCCHH
EAVTGLDLVQWQLAIAAGERLALRERDLAPRGHAIEVRVTAEDPDRDFAPRPGRIEQLVW
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEE
PGGPGIRVDSHAYAGYVVPPHYDSLLGKVIAWGLDRAQAIERLDRALRETIIDGVPTPIP
CCCCCCEECCCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHH
LLRRILQHPDFRASRHTTTFLAEYLASQQS
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRKVLIANRGEIALRVLRACRELGVPAVVAYSEADRESLPVRLADEAICIGPAPAERSY
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCEEEECCCCCCCCC
NHIPAIISAAVVTGCDALHPGYGFLAENALLAEICEECGITFIGPRPQTLRALGDKAEAR
CCHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCHHHHH
RLMQRAGLPIVPGSETPVRDASEARRIARKLGYPVLVKAAAGGGGRGMRIVREERELATA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LQVAQQEAQAAFGDPSVYLERYLERPRHVEVQILADQHGNIVAVGERDCSIQRRYQKLIE
HHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPAPDLSARVRDALHEAAVRGARAVGYVGAGTFEFLVDREGHFYFTEANARLQVEHPVT
HCCCCCHHHHHHHHHHHHHHHCCHHEEEECCCCEEEEEECCCCEEEEECCCEEEECCCHH
EAVTGLDLVQWQLAIAAGERLALRERDLAPRGHAIEVRVTAEDPDRDFAPRPGRIEQLVW
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEE
PGGPGIRVDSHAYAGYVVPPHYDSLLGKVIAWGLDRAQAIERLDRALRETIIDGVPTPIP
CCCCCCEECCCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHH
LLRRILQHPDFRASRHTTTFLAEYLASQQS
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]