Click here to switch to the map view.

The map label for this gene is hemL [H]

Identifier: 221633587

GI number: 221633587

Start: 1604401

End: 1605897

Strand: Reverse

Name: hemL [H]

Synonym: trd_1611

Alternate gene names: 221633587

Gene position: 1605897-1604401 (Counterclockwise)

Preceding gene: 221633591

Following gene: 221633585

Centisome position: 80.17

GC content: 64.93

Gene sequence:

>1497_bases
ATGCAGCCAATCGCATCGGTCATGCTCCTTTCTGTCCCGCAGATCGGCTTGGACGCCAGCGCTCGCCTGACCGATAATGC
CTCTCGGCGAGCCGGCGACGCGCGAGGAGGCAAGACGATGGCCCGACGAACGCTGACGATCGAAGAAGAGTATCGCGCCA
AGCACCCGACCTCGCAGGCGCGCTACGAACGTGCTTTGCGGGACTTTCCGAGCGGCGTCACCCACGACGTGCGGTACCAG
AAACCGTTCCCCCTGTACGTCGAGCGGGCCAGTGGCGCACACAAGTGGGACGTCGATGGCAACGAGTTGATCGACTACAC
GATGGGCCATGGAGCCCTGCTCCTCGGTCATGCCCACCCGCAGATCGTCGAGGCAGTCCAGGTGCAGATCCGGCGCGGCA
CACACTATGGTGCCGGGCACGATCTCGAACTGGAATGGGCGGAACGAATCCGCGAGCTCAAGCCTTCCTGTGAGCGGGTC
AAGTTCACCGCCTCCGGAACGGAAGCCACTTTGCTCGCCATGCGACTCGCCCGGGCATATACCGGTCGCGAAAAGATCCT
CAAGTTCGCTGGTCACTTCCACGGTTGGCAGGACTATGCGCTGCCGGGCGAAAAGCCGCCGTTCGACGCGCAGCCGATCC
CGGGGGTGCCTCGTGCTGTCCTCGAATCGGTCGTCGTGGCGCCGGTGAATGACCTCGACTTCGTGGAGCGCCGCCTGGCG
GAAGGGGATATCGCAGCGGTGATCCTGGAACCCAGCGGTGCCTCGTGGGCCTCCATCCCCTTGCCCGAGGGCTTTCTGCA
TCGCCTGCGCGCCATCACCGAGCGGACAGGAACGCTGCTCATCTTCGACGAAGTGATCACCGGTTTCCGCTGGTCGCCCG
GCGGCGTGCAGGGGCTGCTCGGCATCCGCCCCGACCTCACGACGATGGCCAAGATCGTCGCTGGTGGACTCCCCGGTGGG
GCAGTCGGTGGGCGAGCCGACATCATGGCGCTTCTCGAGTTCCGCGACGATCCAGAGTGGAATCGCCGGCGCGTGGCGCA
TCCGGGAACGTTCAATGCCAACCCCTTGTCCGCTGCCGCCGGTTGTGCATGCTTGCAGCTCGTCGCCGATCCGGCTGTTC
AGCGTCATGCCGATGCCATGGCGGCGCGCTTGCGTCGCGGGATGAATCACGTCCTGGTCACCCATGGGATACCCGGCTTC
GTGTGGGGTGAAAGCTCGGTATTTCACATCGCGCTCGGCCACACCTGCACGAACCAGCGTGGCGAGGATATCCGCATGCC
CGAGGGGGTCTCGCCGATCGTGCTGAAAACCGGCATGTCACCGGCACTCGCCACGACGCTCTACCAGGCAATGGTGAACG
AAGGGGTCGATCTCTTCCACGGTGGGGGCCTCTTGAGCGTTGCCCACACGCCTGAGGACATCGACCGGACGATCGAGGCC
TTCGAGCGCGCCGTGCTCCGGATGCGCGACGAGGGATGGTTCGAGCGATCGACGTGA

Upstream 100 bases:

>100_bases
TCGTCTCGTTTGACCAGGATCCGGACACCGCCCAGGGCGTGGCTCAGCCGGGTCGCCTCCTCGAGCGGCGTCGGCAGCTG
GGCCAGGGGAAAGCGCGGCA

Downstream 100 bases:

>100_bases
GGTGAGCGCGGTTCGCGCTCAATCATCACCTGGGCGCGTACCAACGGCCGTCGCCAGCCCGACCGGCGTCCGCCACTCTG
CGCGGCGCGGGTCGATCCCG

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MQPIASVMLLSVPQIGLDASARLTDNASRRAGDARGGKTMARRTLTIEEEYRAKHPTSQARYERALRDFPSGVTHDVRYQ
KPFPLYVERASGAHKWDVDGNELIDYTMGHGALLLGHAHPQIVEAVQVQIRRGTHYGAGHDLELEWAERIRELKPSCERV
KFTASGTEATLLAMRLARAYTGREKILKFAGHFHGWQDYALPGEKPPFDAQPIPGVPRAVLESVVVAPVNDLDFVERRLA
EGDIAAVILEPSGASWASIPLPEGFLHRLRAITERTGTLLIFDEVITGFRWSPGGVQGLLGIRPDLTTMAKIVAGGLPGG
AVGGRADIMALLEFRDDPEWNRRRVAHPGTFNANPLSAAAGCACLQLVADPAVQRHADAMAARLRRGMNHVLVTHGIPGF
VWGESSVFHIALGHTCTNQRGEDIRMPEGVSPIVLKTGMSPALATTLYQAMVNEGVDLFHGGGLLSVAHTPEDIDRTIEA
FERAVLRMRDEGWFERST

Sequences:

>Translated_498_residues
MQPIASVMLLSVPQIGLDASARLTDNASRRAGDARGGKTMARRTLTIEEEYRAKHPTSQARYERALRDFPSGVTHDVRYQ
KPFPLYVERASGAHKWDVDGNELIDYTMGHGALLLGHAHPQIVEAVQVQIRRGTHYGAGHDLELEWAERIRELKPSCERV
KFTASGTEATLLAMRLARAYTGREKILKFAGHFHGWQDYALPGEKPPFDAQPIPGVPRAVLESVVVAPVNDLDFVERRLA
EGDIAAVILEPSGASWASIPLPEGFLHRLRAITERTGTLLIFDEVITGFRWSPGGVQGLLGIRPDLTTMAKIVAGGLPGG
AVGGRADIMALLEFRDDPEWNRRRVAHPGTFNANPLSAAAGCACLQLVADPAVQRHADAMAARLRRGMNHVLVTHGIPGF
VWGESSVFHIALGHTCTNQRGEDIRMPEGVSPIVLKTGMSPALATTLYQAMVNEGVDLFHGGGLLSVAHTPEDIDRTIEA
FERAVLRMRDEGWFERST
>Mature_498_residues
MQPIASVMLLSVPQIGLDASARLTDNASRRAGDARGGKTMARRTLTIEEEYRAKHPTSQARYERALRDFPSGVTHDVRYQ
KPFPLYVERASGAHKWDVDGNELIDYTMGHGALLLGHAHPQIVEAVQVQIRRGTHYGAGHDLELEWAERIRELKPSCERV
KFTASGTEATLLAMRLARAYTGREKILKFAGHFHGWQDYALPGEKPPFDAQPIPGVPRAVLESVVVAPVNDLDFVERRLA
EGDIAAVILEPSGASWASIPLPEGFLHRLRAITERTGTLLIFDEVITGFRWSPGGVQGLLGIRPDLTTMAKIVAGGLPGG
AVGGRADIMALLEFRDDPEWNRRRVAHPGTFNANPLSAAAGCACLQLVADPAVQRHADAMAARLRRGMNHVLVTHGIPGF
VWGESSVFHIALGHTCTNQRGEDIRMPEGVSPIVLKTGMSPALATTLYQAMVNEGVDLFHGGGLLSVAHTPEDIDRTIEA
FERAVLRMRDEGWFERST

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=350, Percent_Identity=27.7142857142857, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI24119277, Length=345, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI37574042, Length=352, Percent_Identity=25.5681818181818, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226442709, Length=321, Percent_Identity=26.1682242990654, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI284507298, Length=237, Percent_Identity=28.2700421940928, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786349, Length=443, Percent_Identity=37.020316027088, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789016, Length=355, Percent_Identity=30.1408450704225, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1787560, Length=322, Percent_Identity=32.2981366459627, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788044, Length=327, Percent_Identity=31.1926605504587, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789759, Length=322, Percent_Identity=29.5031055900621, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693181, Length=315, Percent_Identity=29.5238095238095, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=323, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=327, Percent_Identity=25.0764525993884, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574759, Length=392, Percent_Identity=24.7448979591837, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161085790, Length=392, Percent_Identity=24.7448979591837, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356575, Length=336, Percent_Identity=25.297619047619, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=321, Percent_Identity=23.0529595015576, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 54483; Mature: 54483

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPIASVMLLSVPQIGLDASARLTDNASRRAGDARGGKTMARRTLTIEEEYRAKHPTSQA
CCHHHHHHHHHCCCCCCCCCCEECCCCHHHCCCCCCCHHHHHHEEEECHHHHCCCCCHHH
RYERALRDFPSGVTHDVRYQKPFPLYVERASGAHKWDVDGNELIDYTMGHGALLLGHAHP
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCEEEEECCCCEEEEECCCH
QIVEAVQVQIRRGTHYGAGHDLELEWAERIRELKPSCERVKFTASGTEATLLAMRLARAY
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHH
TGREKILKFAGHFHGWQDYALPGEKPPFDAQPIPGVPRAVLESVVVAPVNDLDFVERRLA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHC
EGDIAAVILEPSGASWASIPLPEGFLHRLRAITERTGTLLIFDEVITGFRWSPGGVQGLL
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCCCEEE
GIRPDLTTMAKIVAGGLPGGAVGGRADIMALLEFRDDPEWNRRRVAHPGTFNANPLSAAA
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
GCACLQLVADPAVQRHADAMAARLRRGMNHVLVTHGIPGFVWGESSVFHIALGHTCTNQR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCEEEEEECCCCCCCC
GEDIRMPEGVSPIVLKTGMSPALATTLYQAMVNEGVDLFHGGGLLSVAHTPEDIDRTIEA
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHHHHHHHHH
FERAVLRMRDEGWFERST
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQPIASVMLLSVPQIGLDASARLTDNASRRAGDARGGKTMARRTLTIEEEYRAKHPTSQA
CCHHHHHHHHHCCCCCCCCCCEECCCCHHHCCCCCCCHHHHHHEEEECHHHHCCCCCHHH
RYERALRDFPSGVTHDVRYQKPFPLYVERASGAHKWDVDGNELIDYTMGHGALLLGHAHP
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCEEEEECCCCEEEEECCCH
QIVEAVQVQIRRGTHYGAGHDLELEWAERIRELKPSCERVKFTASGTEATLLAMRLARAY
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHH
TGREKILKFAGHFHGWQDYALPGEKPPFDAQPIPGVPRAVLESVVVAPVNDLDFVERRLA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHC
EGDIAAVILEPSGASWASIPLPEGFLHRLRAITERTGTLLIFDEVITGFRWSPGGVQGLL
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCCCEEE
GIRPDLTTMAKIVAGGLPGGAVGGRADIMALLEFRDDPEWNRRRVAHPGTFNANPLSAAA
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
GCACLQLVADPAVQRHADAMAARLRRGMNHVLVTHGIPGFVWGESSVFHIALGHTCTNQR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCEEEEEECCCCCCCC
GEDIRMPEGVSPIVLKTGMSPALATTLYQAMVNEGVDLFHGGGLLSVAHTPEDIDRTIEA
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHHHHHHHHH
FERAVLRMRDEGWFERST
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]