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The map label for this gene is gmk [H]

Identifier: 221633591

GI number: 221633591

Start: 1609918

End: 1610571

Strand: Reverse

Name: gmk [H]

Synonym: trd_1615

Alternate gene names: 221633591

Gene position: 1610571-1609918 (Counterclockwise)

Preceding gene: 221633593

Following gene: 221633587

Centisome position: 80.41

GC content: 62.69

Gene sequence:

>654_bases
GTGACGGACGACCTCGGATTGAATACGCAGGCCGATGAACTCCTCGAAGAACTCCGGCAGCGTGTCCGTCCCAAGTTGAT
CGTCATCTCCGGACCATCCGGTGTCGGCAAGGACACCGTCATCGAGCGGATGCGTCAAGCGCATCCCGAGTTCCATTTCG
CGGTCACCGCGACCACGCGTCCGCGTCGGCCTGGTGAGATCGACGGTGTCCATTACATTTTCATGACGCGCGAGGAGTTC
TTGGCCGCTCGTGACCGTGGCGAATTTCTCGAGTCGGCGGAGGTCTACGGACATCTCTACGGTGTCCCCAAGGAGCGGGT
GCGCCGCGCCTTGCGCAGCGGCAAGACGGTGGTCGTCAAAGTCGACGTGCAGGGAGCAGCGTCGATCCGGCGGCTCGTGC
CGCAGGCGATCCTGATCTTCCTCGCCCCACCCTCGATGTCCGAACTGATGCACCGCTTGCGCAGCCGCAAGACGGACGAT
CCGACCACGCTCATGGAGCGGATCGCGACCGCATCCCGGGAACTCGCTCAGGTTTACGAGTTCGACTACGTCGTCTTCAA
CGAGACGGATCGGTTGGACCAGACGCTTGCCACGATCGACGCGATCCTCGTTGCGGAGCAGAGCCGCGTCCATCAGGCCG
AAATCGTGCTCTGA

Upstream 100 bases:

>100_bases
TTCGAGTCCGACGAGCGTTCCCAACTATGGCACAATGACGACAGGTGGCCGATCCGAGCCACCCCAGGGTGGGAGCGGAC
AGCAGGGGAGGTCCGGGCCG

Downstream 100 bases:

>100_bases
GGTTCACGTCCCGGTCGCCGCTTCGGCGGTCTCTTCTTCCTCGTCCGGGATGTAGCGCAGCGTCGACCGATCTTCGATCC
GGTCGACGAAGAGAATACCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTDDLGLNTQADELLEELRQRVRPKLIVISGPSGVGKDTVIERMRQAHPEFHFAVTATTRPRRPGEIDGVHYIFMTREEF
LAARDRGEFLESAEVYGHLYGVPKERVRRALRSGKTVVVKVDVQGAASIRRLVPQAILIFLAPPSMSELMHRLRSRKTDD
PTTLMERIATASRELAQVYEFDYVVFNETDRLDQTLATIDAILVAEQSRVHQAEIVL

Sequences:

>Translated_217_residues
MTDDLGLNTQADELLEELRQRVRPKLIVISGPSGVGKDTVIERMRQAHPEFHFAVTATTRPRRPGEIDGVHYIFMTREEF
LAARDRGEFLESAEVYGHLYGVPKERVRRALRSGKTVVVKVDVQGAASIRRLVPQAILIFLAPPSMSELMHRLRSRKTDD
PTTLMERIATASRELAQVYEFDYVVFNETDRLDQTLATIDAILVAEQSRVHQAEIVL
>Mature_216_residues
TDDLGLNTQADELLEELRQRVRPKLIVISGPSGVGKDTVIERMRQAHPEFHFAVTATTRPRRPGEIDGVHYIFMTREEFL
AARDRGEFLESAEVYGHLYGVPKERVRRALRSGKTVVVKVDVQGAASIRRLVPQAILIFLAPPSMSELMHRLRSRKTDDP
TTLMERIATASRELAQVYEFDYVVFNETDRLDQTLATIDAILVAEQSRVHQAEIVL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=39.0374331550802, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=39.0374331550802, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=39.0374331550802, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI38570142, Length=172, Percent_Identity=33.1395348837209, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI14780902, Length=203, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21361598, Length=182, Percent_Identity=27.4725274725275, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=187, Percent_Identity=38.5026737967914, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=37.7906976744186, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=37.7906976744186, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71988041, Length=186, Percent_Identity=27.9569892473118, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988048, Length=186, Percent_Identity=27.9569892473118, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17557440, Length=188, Percent_Identity=30.3191489361702, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17556244, Length=122, Percent_Identity=34.4262295081967, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=190, Percent_Identity=36.3157894736842, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21356141, Length=153, Percent_Identity=40.5228758169935, Blast_Score=113, Evalue=8e-26,
Organism=Drosophila melanogaster, GI221330164, Length=121, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221330166, Length=121, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221330162, Length=121, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648808, Length=190, Percent_Identity=26.8421052631579, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281362230, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI161078487, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI161078485, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648810, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362232, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85816106, Length=147, Percent_Identity=32.6530612244898, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816281, Length=147, Percent_Identity=32.6530612244898, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551002, Length=147, Percent_Identity=32.6530612244898, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24623; Mature: 24491

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDLGLNTQADELLEELRQRVRPKLIVISGPSGVGKDTVIERMRQAHPEFHFAVTATTR
CCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCC
PRRPGEIDGVHYIFMTREEFLAARDRGEFLESAEVYGHLYGVPKERVRRALRSGKTVVVK
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEE
VDVQGAASIRRLVPQAILIFLAPPSMSELMHRLRSRKTDDPTTLMERIATASRELAQVYE
EECCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FDYVVFNETDRLDQTLATIDAILVAEQSRVHQAEIVL
HCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDDLGLNTQADELLEELRQRVRPKLIVISGPSGVGKDTVIERMRQAHPEFHFAVTATTR
CCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCC
PRRPGEIDGVHYIFMTREEFLAARDRGEFLESAEVYGHLYGVPKERVRRALRSGKTVVVK
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEE
VDVQGAASIRRLVPQAILIFLAPPSMSELMHRLRSRKTDDPTTLMERIATASRELAQVYE
EECCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FDYVVFNETDRLDQTLATIDAILVAEQSRVHQAEIVL
HCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA