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The map label for this gene is phoP [H]

Identifier: 221633576

GI number: 221633576

Start: 1592372

End: 1593091

Strand: Reverse

Name: phoP [H]

Synonym: trd_1600

Alternate gene names: 221633576

Gene position: 1593091-1592372 (Counterclockwise)

Preceding gene: 221633585

Following gene: 221633575

Centisome position: 79.54

GC content: 67.08

Gene sequence:

>720_bases
GTGCCCACGATCTTGCTCGTCGAAGACGACGACACACTGCAAGCGACGATCCGCTACAACCTCGAGCGGGAGGGCTATTC
GGTCATCGTGGCCGACGCTGGCGAGGCCGCGCTCGAGCAGGCAGCGTTCGCCCGCCCCGACCTGGTCATTCTGGACATCA
TGCTGCCTGGTCTCGACGGCTTCCAGGTCTGCCGCCAACTGCGCGAGCAGAGCACTGTGCCGATCCTCATCCTGACGGCC
CGCGATACCGAGGTCGATCGCGTGCTCGGGCTGGAGCTGGGCGCCGACGACTACCTCACCAAACCCTTCTCGATGCGCGA
ACTCCTCGCGCGCGTCAAGGCGCTCCTCCGCCGCCGCGAGCTTTTGGCCAGAGAACTGGCTGCCGGCTTCTCCCCCGACA
TCCTGGAGATCGGCCCGTTGCGGATCGATCTCGAGCAACGGCGCGTCTGGCGCGAAGGGCGCGAGGTCGCGCTCAAGCCT
CGCGAGTTCGATTTGCTCGCCTACCTGGCCCGGCACCGGGAGCGCGTCTGCCGCTCCGAGGAACTGCTTCGCGCGGTCTG
GGGCTACGACACGTTCGGCGATTTCCGCACGCTGGCTGTGCACGTGCACGGGCTGCGCGAAAAGCTCGAGGACGATCCAC
GCCGTCCGCGGTTGATCGAGACGGTTCGGGGCATCGGCTATCGCTTGACCGCGCGCTCACCACAAGCGACACGCCGCTGA

Upstream 100 bases:

>100_bases
CGCCTCCCGAACGTGTGCCGAATCCTACCAGCTCCCCAGTCGCCACGTCGATGCCGGATACTGTCCGATCCCTGGTACAC
TTCTCGATCAGGAGGGGGTC

Downstream 100 bases:

>100_bases
TGGTCATCGCTCCGTCACGATTTCCGCTCGTGCGATCGGTACGCTCCCATCGAGGGTAGCCAGCGATGCTCACGCTCTTC
CTCGCCACCGCTCTCGCCTT

Product: alkaline phosphatase synthesis transcriptional regulatory protein PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MPTILLVEDDDTLQATIRYNLEREGYSVIVADAGEAALEQAAFARPDLVILDIMLPGLDGFQVCRQLREQSTVPILILTA
RDTEVDRVLGLELGADDYLTKPFSMRELLARVKALLRRRELLARELAAGFSPDILEIGPLRIDLEQRRVWREGREVALKP
REFDLLAYLARHRERVCRSEELLRAVWGYDTFGDFRTLAVHVHGLREKLEDDPRRPRLIETVRGIGYRLTARSPQATRR

Sequences:

>Translated_239_residues
MPTILLVEDDDTLQATIRYNLEREGYSVIVADAGEAALEQAAFARPDLVILDIMLPGLDGFQVCRQLREQSTVPILILTA
RDTEVDRVLGLELGADDYLTKPFSMRELLARVKALLRRRELLARELAAGFSPDILEIGPLRIDLEQRRVWREGREVALKP
REFDLLAYLARHRERVCRSEELLRAVWGYDTFGDFRTLAVHVHGLREKLEDDPRRPRLIETVRGIGYRLTARSPQATRR
>Mature_238_residues
PTILLVEDDDTLQATIRYNLEREGYSVIVADAGEAALEQAAFARPDLVILDIMLPGLDGFQVCRQLREQSTVPILILTAR
DTEVDRVLGLELGADDYLTKPFSMRELLARVKALLRRRELLARELAAGFSPDILEIGPLRIDLEQRRVWREGREVALKPR
EFDLLAYLARHRERVCRSEELLRAVWGYDTFGDFRTLAVHVHGLREKLEDDPRRPRLIETVRGIGYRLTARSPQATRR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=40.0862068965517, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=40, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=39.1304347826087, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786784, Length=233, Percent_Identity=39.9141630901288, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=39.4736842105263, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=39.9141630901288, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=40, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=39.1489361702128, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=39.0557939914163, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=35.0649350649351, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=40.0881057268723, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=35.6223175965665, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=35.4978354978355, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=31.0043668122271, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.0188679245283, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=114, Percent_Identity=35.0877192982456, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI48994928, Length=117, Percent_Identity=38.4615384615385, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27455; Mature: 27324

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTILLVEDDDTLQATIRYNLEREGYSVIVADAGEAALEQAAFARPDLVILDIMLPGLDG
CCEEEEEECCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCH
FQVCRQLREQSTVPILILTARDTEVDRVLGLELGADDYLTKPFSMRELLARVKALLRRRE
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHCEECCCHHHCCCHHHHHHHHHHHHHHHHHH
LLARELAAGFSPDILEIGPLRIDLEQRRVWREGREVALKPREFDLLAYLARHRERVCRSE
HHHHHHHCCCCCCCEEECCEEEEHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHH
ELLRAVWGYDTFGDFRTLAVHVHGLREKLEDDPRRPRLIETVRGIGYRLTARSPQATRR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure 
PTILLVEDDDTLQATIRYNLEREGYSVIVADAGEAALEQAAFARPDLVILDIMLPGLDG
CEEEEEECCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCH
FQVCRQLREQSTVPILILTARDTEVDRVLGLELGADDYLTKPFSMRELLARVKALLRRRE
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHCEECCCHHHCCCHHHHHHHHHHHHHHHHHH
LLARELAAGFSPDILEIGPLRIDLEQRRVWREGREVALKPREFDLLAYLARHRERVCRSE
HHHHHHHCCCCCCCEEECCEEEEHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHH
ELLRAVWGYDTFGDFRTLAVHVHGLREKLEDDPRRPRLIETVRGIGYRLTARSPQATRR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]