Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 221633364

GI number: 221633364

Start: 1374090

End: 1375220

Strand: Reverse

Name: hemE [H]

Synonym: trd_1384

Alternate gene names: 221633364

Gene position: 1375220-1374090 (Counterclockwise)

Preceding gene: 221633367

Following gene: 221633363

Centisome position: 68.66

GC content: 63.48

Gene sequence:

>1131_bases
GTGCGCACAGTGGTAGACTCGGAACGAAGCGGATGGGTCACCATGCCCATCTCGATGGCCAAAGAGGCAGAAGGAGATCA
TCGATCGGATGACGCAATGGTAAATTCACCCCTGCTGCGGGCGTGCCGTCGAAAAACGGTCGACATGACTCCCGTGTGGT
TGATGCGGCAAGCTGGGCGGTATCTTCCGGAATACCGTGCCTTGCGCGAGCGTTACAGCCTCTTGGAACTCTGTCGCCAA
CCGGAACTCGCCGCCGAAGTGACACTCCAGCCGCTCCGCCGTTATCCTCTCGACGCAGCGATCATCTTTGCCGATATCCT
GCTGCCAGTGCTCGCGCTCGGTGTACCGCTCAGCTTCGCCGAGGGCGAAGGGCCGGTCATCGGTGCGCCGATCCGCGATC
CGGCAGCGGTCGACCGGCTCCCTGAACCGGACGAAAGTCCTCTGTGGCCGGTGGCCGAGGCGATCCGGATCGTGCGAGCG
GAATTGCCGGAGCGGGTGGCAGTCATCGGTTTCGCGGGGGCTCCCTTCACACTGGCCAGCTACCTGATCGAGGGTGGGAG
CTCCCGCCAGTACGTGCGGACGAAACGATTTCTCCTCACCGAGCGGTCTGCTTGGGAACGCTTGCTGGAGCGCTTGACCG
AGCTCACGATCCGCTATCTCATGCTGCAGGTTCGCGCTGGCGCAGAGGTCGTTCAGCTCTTCGACAGCTGGGCAGGAGCA
TTGGCACCGGCTGTCTACCGTGACGCGGTGCTTCCGTGGACACGACGCATCGTTGCAGCGGTTCGCGAACTCGGCGTCCC
GGTCATCGTCTTCAGCACTGGAACAGCCGGCTATCTCGATCTGGTGGCTGACACGGGAGCCGATGTCATCGGCGTGGACT
GGCGGATCGAGCTCGATCGTGCCTGGAACGCGATCGGCGCGCGAGCGATCCAAGGGAATCTCGATCCGGCTTGGCTCCTC
GCTCCAGCTGAGGACCTTCGGAAAGCTGCGCGCGATGTCTTGGACCGTGCAGCAGGCCGACCCGGTCACATTTTCAACCT
CGGGCACGGCGTGCTGCCGGAGACATCGCCCGATGCGGTCGCGATCCTCGTCGAGTTCGTGCACGAGTACAGCGCCCGTG
TCCGAGACTGA

Upstream 100 bases:

>100_bases
CTCGGAACCCGGCGATGGCCGGTGCGTAGCCAATCTCTCCTATGTGAGGCACTGAAGGTACTGATCGGGTGAATTTGCAA
AAAGGAGGGAACTTGCACTG

Downstream 100 bases:

>100_bases
GTATGAGAAGGGAGGAAAACCGTGACACGCGAGCGCGTCGCTGTCTTGCTCATGGCCTACGGAGGACCCGATCGTTTGGA
CGATCTTCCGGCCTTCCTCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MRTVVDSERSGWVTMPISMAKEAEGDHRSDDAMVNSPLLRACRRKTVDMTPVWLMRQAGRYLPEYRALRERYSLLELCRQ
PELAAEVTLQPLRRYPLDAAIIFADILLPVLALGVPLSFAEGEGPVIGAPIRDPAAVDRLPEPDESPLWPVAEAIRIVRA
ELPERVAVIGFAGAPFTLASYLIEGGSSRQYVRTKRFLLTERSAWERLLERLTELTIRYLMLQVRAGAEVVQLFDSWAGA
LAPAVYRDAVLPWTRRIVAAVRELGVPVIVFSTGTAGYLDLVADTGADVIGVDWRIELDRAWNAIGARAIQGNLDPAWLL
APAEDLRKAARDVLDRAAGRPGHIFNLGHGVLPETSPDAVAILVEFVHEYSARVRD

Sequences:

>Translated_376_residues
MRTVVDSERSGWVTMPISMAKEAEGDHRSDDAMVNSPLLRACRRKTVDMTPVWLMRQAGRYLPEYRALRERYSLLELCRQ
PELAAEVTLQPLRRYPLDAAIIFADILLPVLALGVPLSFAEGEGPVIGAPIRDPAAVDRLPEPDESPLWPVAEAIRIVRA
ELPERVAVIGFAGAPFTLASYLIEGGSSRQYVRTKRFLLTERSAWERLLERLTELTIRYLMLQVRAGAEVVQLFDSWAGA
LAPAVYRDAVLPWTRRIVAAVRELGVPVIVFSTGTAGYLDLVADTGADVIGVDWRIELDRAWNAIGARAIQGNLDPAWLL
APAEDLRKAARDVLDRAAGRPGHIFNLGHGVLPETSPDAVAILVEFVHEYSARVRD
>Mature_376_residues
MRTVVDSERSGWVTMPISMAKEAEGDHRSDDAMVNSPLLRACRRKTVDMTPVWLMRQAGRYLPEYRALRERYSLLELCRQ
PELAAEVTLQPLRRYPLDAAIIFADILLPVLALGVPLSFAEGEGPVIGAPIRDPAAVDRLPEPDESPLWPVAEAIRIVRA
ELPERVAVIGFAGAPFTLASYLIEGGSSRQYVRTKRFLLTERSAWERLLERLTELTIRYLMLQVRAGAEVVQLFDSWAGA
LAPAVYRDAVLPWTRRIVAAVRELGVPVIVFSTGTAGYLDLVADTGADVIGVDWRIELDRAWNAIGARAIQGNLDPAWLL
APAEDLRKAARDVLDRAAGRPGHIFNLGHGVLPETSPDAVAILVEFVHEYSARVRD

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=41.5254237288136, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=43.3526011560694, Blast_Score=281, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=35.3760445682451, Blast_Score=223, Evalue=5e-59,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=40.6976744186046, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=40.6976744186046, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 41641; Mature: 41641

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVVDSERSGWVTMPISMAKEAEGDHRSDDAMVNSPLLRACRRKTVDMTPVWLMRQAGR
CCCCCCCCCCCEEEECHHHHHHCCCCCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHH
YLPEYRALRERYSLLELCRQPELAAEVTLQPLRRYPLDAAIIFADILLPVLALGVPLSFA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEC
EGEGPVIGAPIRDPAAVDRLPEPDESPLWPVAEAIRIVRAELPERVAVIGFAGAPFTLAS
CCCCCEEECCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
YLIEGGSSRQYVRTKRFLLTERSAWERLLERLTELTIRYLMLQVRAGAEVVQLFDSWAGA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LAPAVYRDAVLPWTRRIVAAVRELGVPVIVFSTGTAGYLDLVADTGADVIGVDWRIELDR
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCEEECEEEEEHHH
AWNAIGARAIQGNLDPAWLLAPAEDLRKAARDVLDRAAGRPGHIFNLGHGVLPETSPDAV
HHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHH
AILVEFVHEYSARVRD
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRTVVDSERSGWVTMPISMAKEAEGDHRSDDAMVNSPLLRACRRKTVDMTPVWLMRQAGR
CCCCCCCCCCCEEEECHHHHHHCCCCCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHH
YLPEYRALRERYSLLELCRQPELAAEVTLQPLRRYPLDAAIIFADILLPVLALGVPLSFA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEC
EGEGPVIGAPIRDPAAVDRLPEPDESPLWPVAEAIRIVRAELPERVAVIGFAGAPFTLAS
CCCCCEEECCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
YLIEGGSSRQYVRTKRFLLTERSAWERLLERLTELTIRYLMLQVRAGAEVVQLFDSWAGA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LAPAVYRDAVLPWTRRIVAAVRELGVPVIVFSTGTAGYLDLVADTGADVIGVDWRIELDR
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCEEECEEEEEHHH
AWNAIGARAIQGNLDPAWLLAPAEDLRKAARDVLDRAAGRPGHIFNLGHGVLPETSPDAV
HHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHH
AILVEFVHEYSARVRD
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA