Click here to switch to the map view.

The map label for this gene is degU [H]

Identifier: 221633346

GI number: 221633346

Start: 1354928

End: 1355668

Strand: Reverse

Name: degU [H]

Synonym: trd_1366

Alternate gene names: 221633346

Gene position: 1355668-1354928 (Counterclockwise)

Preceding gene: 221633348

Following gene: 221633345

Centisome position: 67.68

GC content: 60.59

Gene sequence:

>741_bases
TTGAATGGAGCAAGAAGCGAGCAGAGCCGGACCAGTGATGGGCAGGCGGAGCGGGAGCGCGAGATGGGGAACGGACGGCG
GATTCGGGTGCTGATCGTCGATGACCATGACCTCTTTCGCGAAGGGCTGCGCCAGCTGATCGAGACCGATCCTGCGATCG
AGGTCGTCGGTGAAGCAGCCAATGGTCAGGACGCGCTGAAAATGGTCGCCGAGCTCCAGCCGGATGTGGTGCTCATGGAC
ATCAACATGCCGGGGATGGATGGCATCCGTGCGACGGAGGCGATCGTCCAACAATACCGACATGTTCATGTCCTCATGCT
GACGATGTACGATGACGAGGAGTATGTCCTCCACGCGATTCGTGCCGGAGCGCGCAGTTATCTCGTCAAGAACAGCAAAC
CGGAGGAGTTGCTCCGGGCGATTCATGTCGCCGCCGAGGGTGGTGCCACGATCGACCCGGATCTCGCCCCGATCCTGATG
CGCGAATACCAACGACTTCTGACGAAGGCGCCGACTCGAGGGCAGGACCTCTCGGATCGTGAGCTGACGATGCTGCGGCT
GTTGGCACAGGGTTACAACAATCGCCAGATCGCGGATGCGCTCAATTTGGCCGAGAGCACAGTCAAAAACAACCTTTCTG
CCCTGTTCCAAAAGCTGGGAGTGCGGGATCGCACGCAAGCGGTGATCTACGCCATCTCGCACGGCTTGGTTCCCCGGCCG
ACTGACGTGCCGCGTCGCTGA

Upstream 100 bases:

>100_bases
GGGACAGCCATCGCGTGCACGGTGCCGCTCAGGCGGGCGTTGTGAGCACCATCGGGAAGATCAGGACGTTCCGGTGATGA
CAACTGAGCGAGACTTGGAG

Downstream 100 bases:

>100_bases
GCGTGGCGCTGCGAGCTGATTTGTGGCACAGTATGAGGTGCGCCACCGGTGTCGGTGGCGTTCGTCGTTGTCTTTGGATG
GGTGGGAGGCGAACGGATCA

Product: transcriptional regulatory protein degU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MNGARSEQSRTSDGQAEREREMGNGRRIRVLIVDDHDLFREGLRQLIETDPAIEVVGEAANGQDALKMVAELQPDVVLMD
INMPGMDGIRATEAIVQQYRHVHVLMLTMYDDEEYVLHAIRAGARSYLVKNSKPEELLRAIHVAAEGGATIDPDLAPILM
REYQRLLTKAPTRGQDLSDRELTMLRLLAQGYNNRQIADALNLAESTVKNNLSALFQKLGVRDRTQAVIYAISHGLVPRP
TDVPRR

Sequences:

>Translated_246_residues
MNGARSEQSRTSDGQAEREREMGNGRRIRVLIVDDHDLFREGLRQLIETDPAIEVVGEAANGQDALKMVAELQPDVVLMD
INMPGMDGIRATEAIVQQYRHVHVLMLTMYDDEEYVLHAIRAGARSYLVKNSKPEELLRAIHVAAEGGATIDPDLAPILM
REYQRLLTKAPTRGQDLSDRELTMLRLLAQGYNNRQIADALNLAESTVKNNLSALFQKLGVRDRTQAVIYAISHGLVPRP
TDVPRR
>Mature_246_residues
MNGARSEQSRTSDGQAEREREMGNGRRIRVLIVDDHDLFREGLRQLIETDPAIEVVGEAANGQDALKMVAELQPDVVLMD
INMPGMDGIRATEAIVQQYRHVHVLMLTMYDDEEYVLHAIRAGARSYLVKNSKPEELLRAIHVAAEGGATIDPDLAPILM
REYQRLLTKAPTRGQDLSDRELTMLRLLAQGYNNRQIADALNLAESTVKNNLSALFQKLGVRDRTQAVIYAISHGLVPRP
TDVPRR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=202, Percent_Identity=41.0891089108911, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=35.3488372093023, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=34.4497607655502, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=34.6938775510204, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786747, Length=208, Percent_Identity=27.8846153846154, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=38.7387387387387, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788546, Length=221, Percent_Identity=26.6968325791855, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082052, Length=103, Percent_Identity=37.8640776699029, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27560; Mature: 27560

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGARSEQSRTSDGQAEREREMGNGRRIRVLIVDDHDLFREGLRQLIETDPAIEVVGEAA
CCCCCCCHHCCCCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCCC
NGQDALKMVAELQPDVVLMDINMPGMDGIRATEAIVQQYRHVHVLMLTMYDDEEYVLHAI
CCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEEEEECCHHHHHHHH
RAGARSYLVKNSKPEELLRAIHVAAEGGATIDPDLAPILMREYQRLLTKAPTRGQDLSDR
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
ELTMLRLLAQGYNNRQIADALNLAESTVKNNLSALFQKLGVRDRTQAVIYAISHGLVPRP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TDVPRR
CCCCCC
>Mature Secondary Structure
MNGARSEQSRTSDGQAEREREMGNGRRIRVLIVDDHDLFREGLRQLIETDPAIEVVGEAA
CCCCCCCHHCCCCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCCC
NGQDALKMVAELQPDVVLMDINMPGMDGIRATEAIVQQYRHVHVLMLTMYDDEEYVLHAI
CCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEEEEECCHHHHHHHH
RAGARSYLVKNSKPEELLRAIHVAAEGGATIDPDLAPILMREYQRLLTKAPTRGQDLSDR
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
ELTMLRLLAQGYNNRQIADALNLAESTVKNNLSALFQKLGVRDRTQAVIYAISHGLVPRP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TDVPRR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]