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The map label for this gene is folP [H]

Identifier: 221633305

GI number: 221633305

Start: 1316152

End: 1317000

Strand: Reverse

Name: folP [H]

Synonym: trd_1325

Alternate gene names: 221633305

Gene position: 1317000-1316152 (Counterclockwise)

Preceding gene: 221633306

Following gene: 221633304

Centisome position: 65.75

GC content: 64.19

Gene sequence:

>849_bases
GTGTCGAGTGCTGCAGTCGAGGTACCACGTGTGGACTCTCCACCTTTCGATCGTTGGCCATGGGGGCGCCGCACCTTCGT
GATGGGGATCATCAATGTGACGCCCGATTCGTTCAGTGGTGATGGGCTCGTCGATCGGCTGGAAGAGGTCGTGGAGCGTG
CCCGCGCGATGGTGGAAGCGGGAGCCGACATCCTCGATGTCGGTGGTGAATCGACGCGCCCGGGCCACACGCCCGTTCCA
GCCGAGGAAGAGCTGCGGCGGGTCATCCCAGCGATTCGGGCGATCCGCGCTGCGCTGCCGGACATCCCGATCTCGATCGA
CACCTCCAAGGCGGTGGTCGCCGAGGCGGCTCTGGCTGCGGGTGCGACGATGATCAACGACGTACGGGGTTTGACTGGTG
ATCCAGCGATGGCTTCACTGGCGGCTCAGGCAGGGGTTCCGGTCGTCATCATGCATGACCGGGAAATCCGTCGTCCCGAG
GAACTGATCCCGCGACTGGTGCGGGAACTGGGGCAGCGGATCGATCGTGCCTTGGCTGCGGGCGTGAAATGGGAGCGGAT
CATCATCGATCCAGGATTCGGTTTCGGCAAGGAACCGGAACTCAATCTGTTGCTGCTCCGTCGTCTCCGCGAGGTGACCG
TGCTGGGGCGACCGCTCCTGGTCGGGACATCGCGCAAGCGCACGATCGGGTATGTTTTGGGAACGCCACCAGAGGATCGG
CTCGAGGGGACTGCGGCGACGGTCGCACTCGCGATCGCGAACGGGGCCGATATCGTCCGCGTGCACGATGTTGCGGCGAT
GGTACGGGTTGTACGGATGAGCGATGCAGTGGTGCGTGGAACGTGGTGA

Upstream 100 bases:

>100_bases
TGGAAGCTGGCACCACCGATCGCGGGGGCGCATCTCGAGCGAGTCGGGGTCGAAATTCGTCGGGTACGGGATGCGTGACG
CGGATGCAGGAGGGAACACC

Downstream 100 bases:

>100_bases
TCGTTGCAATCGGCTTGGGCAGCAACCTGGGTGACCGGCGCAAGCTGCTGCGCGACGCGGTCCGCGGGCTCGATGCGGTC
GGGGAGCGGCTGAGCGTCTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSSAAVEVPRVDSPPFDRWPWGRRTFVMGIINVTPDSFSGDGLVDRLEEVVERARAMVEAGADILDVGGESTRPGHTPVP
AEEELRRVIPAIRAIRAALPDIPISIDTSKAVVAEAALAAGATMINDVRGLTGDPAMASLAAQAGVPVVIMHDREIRRPE
ELIPRLVRELGQRIDRALAAGVKWERIIIDPGFGFGKEPELNLLLLRRLREVTVLGRPLLVGTSRKRTIGYVLGTPPEDR
LEGTAATVALAIANGADIVRVHDVAAMVRVVRMSDAVVRGTW

Sequences:

>Translated_282_residues
MSSAAVEVPRVDSPPFDRWPWGRRTFVMGIINVTPDSFSGDGLVDRLEEVVERARAMVEAGADILDVGGESTRPGHTPVP
AEEELRRVIPAIRAIRAALPDIPISIDTSKAVVAEAALAAGATMINDVRGLTGDPAMASLAAQAGVPVVIMHDREIRRPE
ELIPRLVRELGQRIDRALAAGVKWERIIIDPGFGFGKEPELNLLLLRRLREVTVLGRPLLVGTSRKRTIGYVLGTPPEDR
LEGTAATVALAIANGADIVRVHDVAAMVRVVRMSDAVVRGTW
>Mature_281_residues
SSAAVEVPRVDSPPFDRWPWGRRTFVMGIINVTPDSFSGDGLVDRLEEVVERARAMVEAGADILDVGGESTRPGHTPVPA
EEELRRVIPAIRAIRAALPDIPISIDTSKAVVAEAALAAGATMINDVRGLTGDPAMASLAAQAGVPVVIMHDREIRRPEE
LIPRLVRELGQRIDRALAAGVKWERIIIDPGFGFGKEPELNLLLLRRLREVTVLGRPLLVGTSRKRTIGYVLGTPPEDRL
EGTAATVALAIANGADIVRVHDVAAMVRVVRMSDAVVRGTW

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=44.015444015444, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=31.0344827586207, Blast_Score=135, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30424; Mature: 30292

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAVEVPRVDSPPFDRWPWGRRTFVMGIINVTPDSFSGDGLVDRLEEVVERARAMVEA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
GADILDVGGESTRPGHTPVPAEEELRRVIPAIRAIRAALPDIPISIDTSKAVVAEAALAA
CCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
GATMINDVRGLTGDPAMASLAAQAGVPVVIMHDREIRRPEELIPRLVRELGQRIDRALAA
HHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GVKWERIIIDPGFGFGKEPELNLLLLRRLREVTVLGRPLLVGTSRKRTIGYVLGTPPEDR
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCHHH
LEGTAATVALAIANGADIVRVHDVAAMVRVVRMSDAVVRGTW
HCCHHHHEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSAAVEVPRVDSPPFDRWPWGRRTFVMGIINVTPDSFSGDGLVDRLEEVVERARAMVEA
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
GADILDVGGESTRPGHTPVPAEEELRRVIPAIRAIRAALPDIPISIDTSKAVVAEAALAA
CCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
GATMINDVRGLTGDPAMASLAAQAGVPVVIMHDREIRRPEELIPRLVRELGQRIDRALAA
HHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GVKWERIIIDPGFGFGKEPELNLLLLRRLREVTVLGRPLLVGTSRKRTIGYVLGTPPEDR
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCHHH
LEGTAATVALAIANGADIVRVHDVAAMVRVVRMSDAVVRGTW
HCCHHHHEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]