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The map label for this gene is folK [H]

Identifier: 221633304

GI number: 221633304

Start: 1315652

End: 1316155

Strand: Reverse

Name: folK [H]

Synonym: trd_1324

Alternate gene names: 221633304

Gene position: 1316155-1315652 (Counterclockwise)

Preceding gene: 221633305

Following gene: 221633303

Centisome position: 65.71

GC content: 64.09

Gene sequence:

>504_bases
GTGATCGTTGCAATCGGCTTGGGCAGCAACCTGGGTGACCGGCGCAAGCTGCTGCGCGACGCGGTCCGCGGGCTCGATGC
GGTCGGGGAGCGGCTGAGCGTCTCATCCCTTTACGAGACAGAGCCGGTTGGCTTTCGGGAACAGCCCTGGTTCCTGAATG
CGGTCGTCCTCCTGGAGACGAACAGCGATCCGATGTCGCTGATGCAGGTTCTGTCCGCACTCGAACGACGAGCTGGTCGC
GAGCGATCGTTTCCGAATGCACCGCGGACGTTGGACCTGGATCTCTTGCTGTACGGTGAAGACGTCATCGAGACGCCGCA
ACTGGTGGTCCCGCATCCGCGCATGCACGACCGGGCGTTCGTCCTGGTGCCGCTGGCCGAGGTCGCACCGAATCTCGTCC
ATCCGCGATCGGGGAAGACGATACGCGAGCTGCTCGATCGACTCGAGGACTGGTCGAGCGGGATCCGCCGGATCGCTGGT
CTGGAGTGGCTCACTGAGGGTTGA

Upstream 100 bases:

>100_bases
CACTCGCGATCGCGAACGGGGCCGATATCGTCCGCGTGCACGATGTTGCGGCGATGGTACGGGTTGTACGGATGAGCGAT
GCAGTGGTGCGTGGAACGTG

Downstream 100 bases:

>100_bases
TGGTGGGGCAGCAGGAATTCGTCCTCGCTCTCGATATCGGGAGTTCATCCGTTCGTGCCGGCCTTTTCGACCGGACTGGT
CGACTGGTCGAAGGAACAGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MIVAIGLGSNLGDRRKLLRDAVRGLDAVGERLSVSSLYETEPVGFREQPWFLNAVVLLETNSDPMSLMQVLSALERRAGR
ERSFPNAPRTLDLDLLLYGEDVIETPQLVVPHPRMHDRAFVLVPLAEVAPNLVHPRSGKTIRELLDRLEDWSSGIRRIAG
LEWLTEG

Sequences:

>Translated_167_residues
MIVAIGLGSNLGDRRKLLRDAVRGLDAVGERLSVSSLYETEPVGFREQPWFLNAVVLLETNSDPMSLMQVLSALERRAGR
ERSFPNAPRTLDLDLLLYGEDVIETPQLVVPHPRMHDRAFVLVPLAEVAPNLVHPRSGKTIRELLDRLEDWSSGIRRIAG
LEWLTEG
>Mature_167_residues
MIVAIGLGSNLGDRRKLLRDAVRGLDAVGERLSVSSLYETEPVGFREQPWFLNAVVLLETNSDPMSLMQVLSALERRAGR
ERSFPNAPRTLDLDLLLYGEDVIETPQLVVPHPRMHDRAFVLVPLAEVAPNLVHPRSGKTIRELLDRLEDWSSGIRRIAG
LEWLTEG

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=158, Percent_Identity=41.1392405063291, Blast_Score=107, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=155, Percent_Identity=37.4193548387097, Blast_Score=100, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18730; Mature: 18730

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVAIGLGSNLGDRRKLLRDAVRGLDAVGERLSVSSLYETEPVGFREQPWFLNAVVLLET
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEC
NSDPMSLMQVLSALERRAGRERSFPNAPRTLDLDLLLYGEDVIETPQLVVPHPRMHDRAF
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCHHHCCCCEEECCCCCCCCEE
VLVPLAEVAPNLVHPRSGKTIRELLDRLEDWSSGIRRIAGLEWLTEG
EEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVAIGLGSNLGDRRKLLRDAVRGLDAVGERLSVSSLYETEPVGFREQPWFLNAVVLLET
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEC
NSDPMSLMQVLSALERRAGRERSFPNAPRTLDLDLLLYGEDVIETPQLVVPHPRMHDRAF
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCHHHCCCCEEECCCCCCCCEE
VLVPLAEVAPNLVHPRSGKTIRELLDRLEDWSSGIRRIAGLEWLTEG
EEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]