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The map label for this gene is clpP [H]

Identifier: 221633185

GI number: 221633185

Start: 1190394

End: 1191011

Strand: Reverse

Name: clpP [H]

Synonym: trd_1202

Alternate gene names: 221633185

Gene position: 1191011-1190394 (Counterclockwise)

Preceding gene: 221633186

Following gene: 221633184

Centisome position: 59.46

GC content: 58.9

Gene sequence:

>618_bases
ATGGAGCGAGACATCCGACCTGAACTCGTCATCCCGATGGTGATCGAAACGACAAGTCGTGGTGAGCGTGCGTACGATAT
CTACTCGCGCCTGCTCCGCGATCGGATCATCTTTCTTGGAACGCCGATCGACGATCAGGTGGCGAATGCCGTAATCGCCC
AAATGCTGTTCCTGGCACACGAGAACCCGGAGGCTGATATCAAGCTCTATATCAATAGCCCGGGTGGCCTCGTGTACGCT
GGCCTGGCGATCTACGATACGATGCAGATGATCGAGCCGGACGTCGCGACCTACTGTGTAGGACTCGGTGCCAGCATGGC
GGCGGTTCTCCTCGCAGCGGGAACGAAGGGGAAGCGCTTCGCCCTTCCCCACTCGCGGGTTCTGATTCACCAGGGTACTT
CCGGATTCCGCGGCTCGGTGCCGGATATCGAGATCCAGGCACGGGAGACCTTGAATCTGACTACGATGCTGACCGAACTC
CTGGCGTTCCATACCGGTCAGCCGTTCGAGCGTGTGAAACGGGATACCGAGCGAGACTATTTCATGAGCGCGTACGAGGC
GAAGGACTACGGGATCGTGGATCACGTGCTCGAGCCGGTCAAACTCCAGCGAGCGTAG

Upstream 100 bases:

>100_bases
CGACGCCAGCTTCCGAGTCAGCGGAATCGCTGGCGGTAACGGAGACTGGATCCCGAGCGGATGATGACCAGGCATCCTGA
GGGTACGAGGAGGCTATGCG

Downstream 100 bases:

>100_bases
GCGAGCCAACGGGTGGAGAAGGGGCGATGGGGATGACAACGCGTGGGGGACGGGTCTTTTATCGCTGTTCGTTCTGTGGC
AAGAGCCAGGAGGAGGTGCG

Product: Clp protease

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MERDIRPELVIPMVIETTSRGERAYDIYSRLLRDRIIFLGTPIDDQVANAVIAQMLFLAHENPEADIKLYINSPGGLVYA
GLAIYDTMQMIEPDVATYCVGLGASMAAVLLAAGTKGKRFALPHSRVLIHQGTSGFRGSVPDIEIQARETLNLTTMLTEL
LAFHTGQPFERVKRDTERDYFMSAYEAKDYGIVDHVLEPVKLQRA

Sequences:

>Translated_205_residues
MERDIRPELVIPMVIETTSRGERAYDIYSRLLRDRIIFLGTPIDDQVANAVIAQMLFLAHENPEADIKLYINSPGGLVYA
GLAIYDTMQMIEPDVATYCVGLGASMAAVLLAAGTKGKRFALPHSRVLIHQGTSGFRGSVPDIEIQARETLNLTTMLTEL
LAFHTGQPFERVKRDTERDYFMSAYEAKDYGIVDHVLEPVKLQRA
>Mature_205_residues
MERDIRPELVIPMVIETTSRGERAYDIYSRLLRDRIIFLGTPIDDQVANAVIAQMLFLAHENPEADIKLYINSPGGLVYA
GLAIYDTMQMIEPDVATYCVGLGASMAAVLLAAGTKGKRFALPHSRVLIHQGTSGFRGSVPDIEIQARETLNLTTMLTEL
LAFHTGQPFERVKRDTERDYFMSAYEAKDYGIVDHVLEPVKLQRA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=55.3191489361702, Blast_Score=212, Evalue=2e-55,
Organism=Escherichia coli, GI1786641, Length=198, Percent_Identity=60.1010101010101, Blast_Score=251, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=196, Percent_Identity=49.4897959183673, Blast_Score=205, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=52.3809523809524, Blast_Score=208, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22902; Mature: 22902

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERDIRPELVIPMVIETTSRGERAYDIYSRLLRDRIIFLGTPIDDQVANAVIAQMLFLAH
CCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC
ENPEADIKLYINSPGGLVYAGLAIYDTMQMIEPDVATYCVGLGASMAAVLLAAGTKGKRF
CCCCCEEEEEEECCCCEEEEHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCCCEE
ALPHSRVLIHQGTSGFRGSVPDIEIQARETLNLTTMLTELLAFHTGQPFERVKRDTERDY
ECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
FMSAYEAKDYGIVDHVLEPVKLQRA
HHHHHCCCCCCHHHHHHCCHHHCCC
>Mature Secondary Structure
MERDIRPELVIPMVIETTSRGERAYDIYSRLLRDRIIFLGTPIDDQVANAVIAQMLFLAH
CCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC
ENPEADIKLYINSPGGLVYAGLAIYDTMQMIEPDVATYCVGLGASMAAVLLAAGTKGKRF
CCCCCEEEEEEECCCCEEEEHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCCCEE
ALPHSRVLIHQGTSGFRGSVPDIEIQARETLNLTTMLTELLAFHTGQPFERVKRDTERDY
ECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
FMSAYEAKDYGIVDHVLEPVKLQRA
HHHHHCCCCCCHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA