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The map label for this gene is aroB [H]

Identifier: 221632918

GI number: 221632918

Start: 901120

End: 902808

Strand: Reverse

Name: aroB [H]

Synonym: trd_0920

Alternate gene names: 221632918

Gene position: 902808-901120 (Counterclockwise)

Preceding gene: 221632921

Following gene: 221632917

Centisome position: 45.07

GC content: 63.59

Gene sequence:

>1689_bases
GTGATCAAACGGATCGCACTCATCGGGCTCAGCGGGTCAGGGAAGAGTTCGATCGCGCCGCTCGTCGCGGATTTGCTCGG
CTGGCGTGTCGTCGATACTGATCGGCTAGTCGAAGAGCGTTTCGGTCTGCCGATCGCAGAGATCTTTGCGCGGTACGGCG
AGAGCGTTTTCCGAGCAGCAGAGCGAGAAGCTTTGCTGCAGGCGTCACTGGCCGAGCACGTAGTGATCGCCACTGGCGGT
GGCATCGTGTTGGACGATCGGAACTGGATTCCCTTGCGCACCGAGACGGCCTTGGTGCACTTACGTGCACGGATCGAGAC
CTTGGTGGATCGTTTGCACCGCCAGTCTGAACGAGAACTGCAGCCGACTGTTCGGCCGCTGCTCGCTGGCGACACAGCAG
CGAAACTGCAGGAGCTTTGGCAGCGACGGCGAGCGCTCTATGAGCAGGCTGATGTCGTCATCGATACCGATGACGAGGCG
CCGGAGGAGATTGCGCAACGCATCGTCGAAGCAGTGCGAGAGCTGGAGGACCGAGGAAGCGTGCCGTTCCGCGCTCTGCT
CGGTGCTGCCGGGCGCTCCGAACTCTACGTGGCTTCGGGTATTTTGACGAGAATCGGCGAGCTGGTGCGACGCCGTTGGC
CCAAGGCTCGGCGCGCCTTTCTCGTCAGCGATGAGCAGGTCGCGCGATACTGGGGCGCGAGCGCCCGAACGTCACTGACT
GCTGCTGATTTCGATGTCGTGGCGACCGCTATTCCCCCGGGAGAGCACTCGAAGTCGCTCGTGACCGTGGCATCGCTTCT
CGACTGGATGCTGGCGGCCGGCATCGAGCGTTCCGATGTCGTCGTGGCGCTCGGGGGTGGAGTGGTCGGTGACGTCGCCG
GTTTTGCGGCTTCGATTGTCCTCCGTGGTGTCGCGCTCGTGCAAGTGCCGACGAGCCTTTTGGCGATGGTCGATGCGAGC
GTCGGCGGAAAGACGGGGGTCGATCATCCGCTCGGCAAGAATCTCATCGGGAGTTTCTATCAGCCGCATCTGGTGCTGGC
GGATCCAGTCGTGCTCGCGACGCTTCCGGCTGAAGAGCGTCGCTCCGGGTGGGCCGAAGTGGTGAAGCATGCGATGATCG
AGTGCACCGCGACCGAGACGAAGGAACCGCGGCTGCTGAACATGCTCGCCGAGCGGCCGTACGACGCGTGGTGGCAGGAT
GCCGACTCACTCGCGCGGCTCATCCGGCAGAACATTCAGATCAAGGCGAGCGTTGTCGCCCGTGATGAGCGCGAATCCGG
ACTGCGCCGGATTCTCAACTACGGTCACACCTTGGGTCACGCAATCGAGGCGACGAGTGGGTACCGGTTGCGGCATGGCG
AGGCGATCGCGGTGGGTATGCGGGCGGTCGCTCGCATCGCGCATCGACTGGACTCCTGTCGCGCAGATCTCGTTCCGTTG
CAGGACGAGCTCCTGGATCAGGCCGGGTTACCGCGTGCGGTCGATCTCCCACTCGCCGATGTGCTCGAGCGCCTTCGTTA
TGACAAAAAAGCCGAAGGCGGACGCCTCACCTGGATTCTGCCGCTCGCACCGGGTCACGTCGAGGTGCGGCGCGACGTGC
CCATGAGCGTGATCGAGGACATCTGCCGAGCACTGCTGAGAACCGAATCGAGGATCGTGAGCGGGAGAGGTGCCGGGGGA
GACCGATGA

Upstream 100 bases:

>100_bases
CGGCCTTCGCTGAGCGTATCCTAGCACACATCTGAATCCGCTCGTGGGATACAATCGCTCGGAGGCGGCGCCTCGCTCAC
GGATCGTGAAGGGGTCGCAG

Downstream 100 bases:

>100_bases
CGGATGCGCCGAGCGAATGGCGACCCCTTCACTGGACGGGAGAGTCGCTCGTCATCGTCGATCAAACGGCTCTTCCGGAT
GAAGAGCGGCTTGTCGAGTG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MIKRIALIGLSGSGKSSIAPLVADLLGWRVVDTDRLVEERFGLPIAEIFARYGESVFRAAEREALLQASLAEHVVIATGG
GIVLDDRNWIPLRTETALVHLRARIETLVDRLHRQSERELQPTVRPLLAGDTAAKLQELWQRRRALYEQADVVIDTDDEA
PEEIAQRIVEAVRELEDRGSVPFRALLGAAGRSELYVASGILTRIGELVRRRWPKARRAFLVSDEQVARYWGASARTSLT
AADFDVVATAIPPGEHSKSLVTVASLLDWMLAAGIERSDVVVALGGGVVGDVAGFAASIVLRGVALVQVPTSLLAMVDAS
VGGKTGVDHPLGKNLIGSFYQPHLVLADPVVLATLPAEERRSGWAEVVKHAMIECTATETKEPRLLNMLAERPYDAWWQD
ADSLARLIRQNIQIKASVVARDERESGLRRILNYGHTLGHAIEATSGYRLRHGEAIAVGMRAVARIAHRLDSCRADLVPL
QDELLDQAGLPRAVDLPLADVLERLRYDKKAEGGRLTWILPLAPGHVEVRRDVPMSVIEDICRALLRTESRIVSGRGAGG
DR

Sequences:

>Translated_562_residues
MIKRIALIGLSGSGKSSIAPLVADLLGWRVVDTDRLVEERFGLPIAEIFARYGESVFRAAEREALLQASLAEHVVIATGG
GIVLDDRNWIPLRTETALVHLRARIETLVDRLHRQSERELQPTVRPLLAGDTAAKLQELWQRRRALYEQADVVIDTDDEA
PEEIAQRIVEAVRELEDRGSVPFRALLGAAGRSELYVASGILTRIGELVRRRWPKARRAFLVSDEQVARYWGASARTSLT
AADFDVVATAIPPGEHSKSLVTVASLLDWMLAAGIERSDVVVALGGGVVGDVAGFAASIVLRGVALVQVPTSLLAMVDAS
VGGKTGVDHPLGKNLIGSFYQPHLVLADPVVLATLPAEERRSGWAEVVKHAMIECTATETKEPRLLNMLAERPYDAWWQD
ADSLARLIRQNIQIKASVVARDERESGLRRILNYGHTLGHAIEATSGYRLRHGEAIAVGMRAVARIAHRLDSCRADLVPL
QDELLDQAGLPRAVDLPLADVLERLRYDKKAEGGRLTWILPLAPGHVEVRRDVPMSVIEDICRALLRTESRIVSGRGAGG
DR
>Mature_562_residues
MIKRIALIGLSGSGKSSIAPLVADLLGWRVVDTDRLVEERFGLPIAEIFARYGESVFRAAEREALLQASLAEHVVIATGG
GIVLDDRNWIPLRTETALVHLRARIETLVDRLHRQSERELQPTVRPLLAGDTAAKLQELWQRRRALYEQADVVIDTDDEA
PEEIAQRIVEAVRELEDRGSVPFRALLGAAGRSELYVASGILTRIGELVRRRWPKARRAFLVSDEQVARYWGASARTSLT
AADFDVVATAIPPGEHSKSLVTVASLLDWMLAAGIERSDVVVALGGGVVGDVAGFAASIVLRGVALVQVPTSLLAMVDAS
VGGKTGVDHPLGKNLIGSFYQPHLVLADPVVLATLPAEERRSGWAEVVKHAMIECTATETKEPRLLNMLAERPYDAWWQD
ADSLARLIRQNIQIKASVVARDERESGLRRILNYGHTLGHAIEATSGYRLRHGEAIAVGMRAVARIAHRLDSCRADLVPL
QDELLDQAGLPRAVDLPLADVLERLRYDKKAEGGRLTWILPLAPGHVEVRRDVPMSVIEDICRALLRTESRIVSGRGAGG
DR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=346, Percent_Identity=41.6184971098266, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1786587, Length=169, Percent_Identity=36.6863905325444, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082255, Length=170, Percent_Identity=32.3529411764706, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320332, Length=297, Percent_Identity=40.0673400673401, Blast_Score=199, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037 [H]

Pfam domain/function: PF01761 DHQ_synthase [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 61522; Mature: 61522

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRIALIGLSGSGKSSIAPLVADLLGWRVVDTDRLVEERFGLPIAEIFARYGESVFRAA
CCCEEEEEEECCCCCCHHHHHHHHHHCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EREALLQASLAEHVVIATGGGIVLDDRNWIPLRTETALVHLRARIETLVDRLHRQSEREL
HHHHHHHHHHHCEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPTVRPLLAGDTAAKLQELWQRRRALYEQADVVIDTDDEAPEEIAQRIVEAVRELEDRGS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCCC
VPFRALLGAAGRSELYVASGILTRIGELVRRRWPKARRAFLVSDEQVARYWGASARTSLT
CCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHEEECCHHHHHHHHCCCCCCCCE
AADFDVVATAIPPGEHSKSLVTVASLLDWMLAAGIERSDVVVALGGGVVGDVAGFAASIV
ECCHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
LRGVALVQVPTSLLAMVDASVGGKTGVDHPLGKNLIGSFYQPHLVLADPVVLATLPAEER
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEECCEEEEECCCHHH
RSGWAEVVKHAMIECTATETKEPRLLNMLAERPYDAWWQDADSLARLIRQNIQIKASVVA
HCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCEEEHHHH
RDERESGLRRILNYGHTLGHAIEATSGYRLRHGEAIAVGMRAVARIAHRLDSCRADLVPL
CCHHHHHHHHHHHHCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
QDELLDQAGLPRAVDLPLADVLERLRYDKKAEGGRLTWILPLAPGHVEVRRDVPMSVIED
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEECCCCHHHHHH
ICRALLRTESRIVSGRGAGGDR
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIKRIALIGLSGSGKSSIAPLVADLLGWRVVDTDRLVEERFGLPIAEIFARYGESVFRAA
CCCEEEEEEECCCCCCHHHHHHHHHHCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EREALLQASLAEHVVIATGGGIVLDDRNWIPLRTETALVHLRARIETLVDRLHRQSEREL
HHHHHHHHHHHCEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPTVRPLLAGDTAAKLQELWQRRRALYEQADVVIDTDDEAPEEIAQRIVEAVRELEDRGS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCCC
VPFRALLGAAGRSELYVASGILTRIGELVRRRWPKARRAFLVSDEQVARYWGASARTSLT
CCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHEEECCHHHHHHHHCCCCCCCCE
AADFDVVATAIPPGEHSKSLVTVASLLDWMLAAGIERSDVVVALGGGVVGDVAGFAASIV
ECCHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
LRGVALVQVPTSLLAMVDASVGGKTGVDHPLGKNLIGSFYQPHLVLADPVVLATLPAEER
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEECCEEEEECCCHHH
RSGWAEVVKHAMIECTATETKEPRLLNMLAERPYDAWWQDADSLARLIRQNIQIKASVVA
HCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCEEEHHHH
RDERESGLRRILNYGHTLGHAIEATSGYRLRHGEAIAVGMRAVARIAHRLDSCRADLVPL
CCHHHHHHHHHHHHCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
QDELLDQAGLPRAVDLPLADVLERLRYDKKAEGGRLTWILPLAPGHVEVRRDVPMSVIED
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEECCCCHHHHHH
ICRALLRTESRIVSGRGAGGDR
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA