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The map label for this gene is gmd [H]

Identifier: 221632914

GI number: 221632914

Start: 896456

End: 897457

Strand: Reverse

Name: gmd [H]

Synonym: trd_0916

Alternate gene names: 221632914

Gene position: 897457-896456 (Counterclockwise)

Preceding gene: 221632915

Following gene: 221632912

Centisome position: 44.81

GC content: 60.38

Gene sequence:

>1002_bases
ATGCGGCGAGCCTTGATCACCGGTGCGACCGGGTTCGCTGGACGGTACCTCGCGGATCGACTGGCCGCAACGGGTCATTG
GGAGGTGATTGGGCTCTCGGCGCGACCCAGCCCGCCGGCCTCGTCACTGAAACAGCACCTTGTCTGTGATCTCATGAACG
GCGAACTCGTTCGCCGCACATTGGCACACTGGCACCCTGAGGTGATCTTTCACCTGGCAGCCGTCAGTTACGTTCCGCGT
TCTTTTCAGGACCCTTACGGAACGATCGCGAACAACGTTCTCGGACAGGTCAACTTGCTGGAGGCAGTTCGTTCGCTCGA
ACCACCACCGCTGGTCGTCATCGTCAGTTCGTCGGATGCCTACGGCCTCGTCTACGAACATGAGCTTCCGGTCACAGAGT
CCCAACCGTTTCGGCCACTGAGCCCGTACGGTGTGAGCAAGGCGACGCAGGATCTCTTGGGACTTCAGTATCATCTGACC
TATGGTTTACCGATCGTGCGAGTCCGTCCTTTTACTCATATCGGGCCAGGCCAAAGCGAGCGATTTGCGCTCTCCGGATT
TGCCCGTCAGATCGCGGAAGCTGAGTTGGGTATGGCGCCGCCCGTTCTCCTCGTCGGTGAACTCGACGTCGAACGGGATC
TTCTCGACGTGCGCGACGTCGTCCGAGCTTATGAACTCTTGGCCGAGCCCCGTTTCAGTGGCGAGGTCTTCAATCTCGCC
AGTGGGGTGTCGTGGTCACTCCGCGCGTTGGTCGAGCGGTTGCTGTCGCTCGCGCGTATTCCGTTGCGACTGGAACGTGA
CCCTGCTCGTCTCCGCCCGATCGATGTACGTGTTCTTCGGGGAGATGCGACAGCCTTGCGCACGGCCACTGGTTGGCAGC
CAACAATACCGATCGAGCAAACACTCGAGGATATGCTGGAATACTGGCGGCGAACCTTGCGGCCCTCACGCACCGGTGAT
CGATCGGTGTTCGGCGAGCACGGTGAGCGTTCCCCCTTGTAG

Upstream 100 bases:

>100_bases
GATTTGCCCTGGGAGCGGACGGACAAGGCAGAGTTGCTTCGGTCGGAAGCGGGGCTGGTCGGAAGCCTACCGGAGCGATG
ACGGAAGAGTGGGCGCTCCT

Downstream 100 bases:

>100_bases
AGACAACGTCAGAAGAGACTCTACCGTTTCGGCAGAAAGGGTTGGCCGGGACGACCATCCGAGACAGCGGCGAACGATCC
AGACACGGCCTTCATGATCC

Product: GDP-6-deoxy-D-lyxo-4-hexulose reductase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MRRALITGATGFAGRYLADRLAATGHWEVIGLSARPSPPASSLKQHLVCDLMNGELVRRTLAHWHPEVIFHLAAVSYVPR
SFQDPYGTIANNVLGQVNLLEAVRSLEPPPLVVIVSSSDAYGLVYEHELPVTESQPFRPLSPYGVSKATQDLLGLQYHLT
YGLPIVRVRPFTHIGPGQSERFALSGFARQIAEAELGMAPPVLLVGELDVERDLLDVRDVVRAYELLAEPRFSGEVFNLA
SGVSWSLRALVERLLSLARIPLRLERDPARLRPIDVRVLRGDATALRTATGWQPTIPIEQTLEDMLEYWRRTLRPSRTGD
RSVFGEHGERSPL

Sequences:

>Translated_333_residues
MRRALITGATGFAGRYLADRLAATGHWEVIGLSARPSPPASSLKQHLVCDLMNGELVRRTLAHWHPEVIFHLAAVSYVPR
SFQDPYGTIANNVLGQVNLLEAVRSLEPPPLVVIVSSSDAYGLVYEHELPVTESQPFRPLSPYGVSKATQDLLGLQYHLT
YGLPIVRVRPFTHIGPGQSERFALSGFARQIAEAELGMAPPVLLVGELDVERDLLDVRDVVRAYELLAEPRFSGEVFNLA
SGVSWSLRALVERLLSLARIPLRLERDPARLRPIDVRVLRGDATALRTATGWQPTIPIEQTLEDMLEYWRRTLRPSRTGD
RSVFGEHGERSPL
>Mature_333_residues
MRRALITGATGFAGRYLADRLAATGHWEVIGLSARPSPPASSLKQHLVCDLMNGELVRRTLAHWHPEVIFHLAAVSYVPR
SFQDPYGTIANNVLGQVNLLEAVRSLEPPPLVVIVSSSDAYGLVYEHELPVTESQPFRPLSPYGVSKATQDLLGLQYHLT
YGLPIVRVRPFTHIGPGQSERFALSGFARQIAEAELGMAPPVLLVGELDVERDLLDVRDVVRAYELLAEPRFSGEVFNLA
SGVSWSLRALVERLLSLARIPLRLERDPARLRPIDVRVLRGDATALRTATGWQPTIPIEQTLEDMLEYWRRTLRPSRTGD
RSVFGEHGERSPL

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=342, Percent_Identity=28.0701754385965, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788366, Length=350, Percent_Identity=30.2857142857143, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI48994969, Length=262, Percent_Identity=30.1526717557252, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=26.7647058823529, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI133901786, Length=342, Percent_Identity=26.6081871345029, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI133901790, Length=344, Percent_Identity=26.453488372093, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17539424, Length=344, Percent_Identity=26.453488372093, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17539422, Length=344, Percent_Identity=26.453488372093, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI133901788, Length=344, Percent_Identity=26.453488372093, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17507723, Length=342, Percent_Identity=26.9005847953216, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17568069, Length=326, Percent_Identity=24.8466257668712, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24158427, Length=340, Percent_Identity=26.4705882352941, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356223, Length=326, Percent_Identity=25.7668711656442, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 37042; Mature: 37042

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRALITGATGFAGRYLADRLAATGHWEVIGLSARPSPPASSLKQHLVCDLMNGELVRRT
CCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHH
LAHWHPEVIFHLAAVSYVPRSFQDPYGTIANNVLGQVNLLEAVRSLEPPPLVVIVSSSDA
HHHHCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
YGLVYEHELPVTESQPFRPLSPYGVSKATQDLLGLQYHLTYGLPIVRVRPFTHIGPGQSE
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCEEEEECCCCCCCCCCCC
RFALSGFARQIAEAELGMAPPVLLVGELDVERDLLDVRDVVRAYELLAEPRFSGEVFNLA
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SGVSWSLRALVERLLSLARIPLRLERDPARLRPIDVRVLRGDATALRTATGWQPTIPIEQ
CCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEEECCCHHHEECCCCCCCCCHHH
TLEDMLEYWRRTLRPSRTGDRSVFGEHGERSPL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRALITGATGFAGRYLADRLAATGHWEVIGLSARPSPPASSLKQHLVCDLMNGELVRRT
CCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHH
LAHWHPEVIFHLAAVSYVPRSFQDPYGTIANNVLGQVNLLEAVRSLEPPPLVVIVSSSDA
HHHHCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
YGLVYEHELPVTESQPFRPLSPYGVSKATQDLLGLQYHLTYGLPIVRVRPFTHIGPGQSE
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCEEEEECCCCCCCCCCCC
RFALSGFARQIAEAELGMAPPVLLVGELDVERDLLDVRDVVRAYELLAEPRFSGEVFNLA
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SGVSWSLRALVERLLSLARIPLRLERDPARLRPIDVRVLRGDATALRTATGWQPTIPIEQ
CCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEEECCCHHHEECCCCCCCCCHHH
TLEDMLEYWRRTLRPSRTGDRSVFGEHGERSPL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]