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The map label for this gene is purE [H]

Identifier: 221632663

GI number: 221632663

Start: 638704

End: 639219

Strand: Reverse

Name: purE [H]

Synonym: trd_0646

Alternate gene names: 221632663

Gene position: 639219-638704 (Counterclockwise)

Preceding gene: 221632664

Following gene: 221632662

Centisome position: 31.91

GC content: 63.76

Gene sequence:

>516_bases
GTGCAGGTAACAAACGCTTCCTCGCGCCCGCTCGTCGGCATCATCATGGGCTCACGATCCGACTGGGAGACGATGAGTCA
CGCTGCCAGCACGCTCGATCACCTGAATATTCCGTACGAGGTTCGTGTCGTGTCAGCGCACCGGACTCCGGACCTCATGT
TCGAGTATGCGGCGACAGCCGAAGCACGCGGGATCGAGGTCATCATCGCCGGAGCTGGGGGCGCCGCCCATCTGCCCGGG
ATGACCGCCGCCAAGACTGTCGTACCGGTTCTCGGCGTGCCGGTGCAGACCCACACGCTGCACGGACTCGATTCGCTGCT
TTCGATTGTCCAGATGCCTGCCGGAGTACCGGTCGGCACACTCGCCATCGGTCGCGCCGGTGCAGTCAATGCTGCGCTCC
TGGCAGCAGCTATTCTCGGGACGAAGTACCCCGAGATCCGCGAGCGTCTTCGCCGTTTCCGAGACGAACAAACGCGCGCA
GTTCTGGAGAACCCTGACCCGCGACAGGCACCGTGA

Upstream 100 bases:

>100_bases
CGCTCGCTATCGTTGGAGCCGGGTCCAGCTGCTGCACGAGTTCGATGGGGAGCCTGGTTTCACCCGTGCCCAGGGCGAGG
ATTGAGAGAGGTACGGCACT

Downstream 100 bases:

>100_bases
AGGAGCGACCGATGCGCATCGGCATTCTCGGCGGAGGGCAACTCGGGCGAATGCTGGCGCTCGCCGGTTATCCGCTCGGT
CTGCACTTTCGCGGTCTCGA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MQVTNASSRPLVGIIMGSRSDWETMSHAASTLDHLNIPYEVRVVSAHRTPDLMFEYAATAEARGIEVIIAGAGGAAHLPG
MTAAKTVVPVLGVPVQTHTLHGLDSLLSIVQMPAGVPVGTLAIGRAGAVNAALLAAAILGTKYPEIRERLRRFRDEQTRA
VLENPDPRQAP

Sequences:

>Translated_171_residues
MQVTNASSRPLVGIIMGSRSDWETMSHAASTLDHLNIPYEVRVVSAHRTPDLMFEYAATAEARGIEVIIAGAGGAAHLPG
MTAAKTVVPVLGVPVQTHTLHGLDSLLSIVQMPAGVPVGTLAIGRAGAVNAALLAAAILGTKYPEIRERLRRFRDEQTRA
VLENPDPRQAP
>Mature_171_residues
MQVTNASSRPLVGIIMGSRSDWETMSHAASTLDHLNIPYEVRVVSAHRTPDLMFEYAATAEARGIEVIIAGAGGAAHLPG
MTAAKTVVPVLGVPVQTHTLHGLDSLLSIVQMPAGVPVGTLAIGRAGAVNAALLAAAILGTKYPEIRERLRRFRDEQTRA
VLENPDPRQAP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=66.6666666666667, Blast_Score=180, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324702, Length=154, Percent_Identity=55.1948051948052, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18101; Mature: 18101

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTNASSRPLVGIIMGSRSDWETMSHAASTLDHLNIPYEVRVVSAHRTPDLMFEYAATA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCC
EARGIEVIIAGAGGAAHLPGMTAAKTVVPVLGVPVQTHTLHGLDSLLSIVQMPAGVPVGT
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
LAIGRAGAVNAALLAAAILGTKYPEIRERLRRFRDEQTRAVLENPDPRQAP
EECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQVTNASSRPLVGIIMGSRSDWETMSHAASTLDHLNIPYEVRVVSAHRTPDLMFEYAATA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCC
EARGIEVIIAGAGGAAHLPGMTAAKTVVPVLGVPVQTHTLHGLDSLLSIVQMPAGVPVGT
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
LAIGRAGAVNAALLAAAILGTKYPEIRERLRRFRDEQTRAVLENPDPRQAP
EECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]