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The map label for this gene is icd [H]

Identifier: 221632664

GI number: 221632664

Start: 639235

End: 640725

Strand: Reverse

Name: icd [H]

Synonym: trd_0647

Alternate gene names: 221632664

Gene position: 640725-639235 (Counterclockwise)

Preceding gene: 221632665

Following gene: 221632663

Centisome position: 31.99

GC content: 58.48

Gene sequence:

>1491_bases
ATGGAGCAGTCAGGAGGAAGCGGTGCAACGATGAAGTACGTCGTGACCCCGAATGGGAAAAAACTCGTGACCTTGATACC
TGGCGACGGCATCGGACCGGAGATCGTGGAGAGTGCTTGCCGACTCATCGAGGCGGTTGGTGCACCGATCGAGTGGGAAG
TCCGCCGGGCCGGTGCGAGCGTCTTCCGAGAAGGGATCGCGAGCGGTGTACCCGACGACACGATCGAGTCGATCAAGCGC
ACCCGGGTGGTCCTGAAGGGACCACTGGAAACACCGGTCGGCTATGGCGAGAAGAGTGCCAATGTGACGTTGCGCAAGCT
CTTCGAGGCATTCGCGAATGTCCGCCCGGTGCGCGAACTCCCCTCGGTTCCCACACCCTACCGCGGACGTAACATCGATC
TCGTCGTCGTTCGCGAGAATATCGAAGATCTCTACGCTGCTATCGAATATCGCGAAACTCCTGGAGTGACCATCGCCCAT
AAGCTGATATCCTATAAAGGGAGCGAAAAGATCATCCGCTTTGCCTTCGAACTCGCCCGCGCAGAAGGCAGGAAGAAGGT
TACCTGCGCGACCAAGTCCAATATTTTGAAACTGACCGAAGGATGGTTTCAGCACATTTTCGAGGAAATCGCTTCCGAGT
ACCCGGACATCGAAGCCAACCACCTCATCATCGATAACTGTGCACACCAACTCGTCAAAGCTCCTGAGCAGTTCGAGGTC
ATCGTCACGACCAATCTGAATGGTGATATCATCTCCGATCTCGCCTCGGGTCTGGTCGGCGGGCTCGGCTTCGCCGCCTC
AGGAAATTACGGCCACGAGGTAGCCATTTTCGAACCTGTGCACGGCACAGCACCGAAATATGCTGGGAAGAACGTCATCA
ATCCTACCGCCATGATCCTCACTGCGGTGATGATGTTGCGCTACATCGACGAGTTCGAGACAGCGGAGACGATCGAGCAA
GCCCTCATCGTCACGCTCGAAGAAGGGAAAGCGCTCACCCGCGATGTCGTCGGCGACGAGCGAGCCGTTTCGACGACGGC
CTTCACCGATGCGATCATCGCCAATCTCGGCCGTCGTTCCGCAACGTGGAAGACACGTCCTTACCAGCCGATTCGTATTC
CTGCACAGCGCCCGGAACTCGATCCAGTTCGTCCCAGTCGACGCCGTGTGGTGGGCGTCGACCTCATCGTCGAGGGAACC
GAACCACCCCAGATCTTGGGGCCTAATCTCGAGCGCCTGATCGACGATCTCCCGCTACGGCTTCACCTCATTTCGAGTCG
TGGCCTTCAGGTCTATCCTGACGTCGGCACCACCATCGATTACGTCGATCACTGGCGCTGCCGATTCCTGAGCCACGACG
GGGAGGTCTCCACAGCAACGGTCACTGCCCTGCTCGAACGACTGAGCGCTCGCTATCGTTGGAGCCGGGTCCAGCTGCTG
CACGAGTTCGATGGGGAGCCTGGTTTCACCCGTGCCCAGGGCGAGGATTGA

Upstream 100 bases:

>100_bases
AATCGCAATAACCTCCAGCCGTGGGAGCGATAAACCAGCGGTTGACAACGGGCCGGTTTCTCGAGTATGGTGCCCGTTCG
GGCTGGGCAGACCGCCAGCG

Downstream 100 bases:

>100_bases
GAGAGGTACGGCACTGTGCAGGTAACAAACGCTTCCTCGCGCCCGCTCGTCGGCATCATCATGGGCTCACGATCCGACTG
GGAGACGATGAGTCACGCTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MEQSGGSGATMKYVVTPNGKKLVTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRAGASVFREGIASGVPDDTIESIKR
TRVVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRGRNIDLVVVRENIEDLYAAIEYRETPGVTIAH
KLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEV
IVTTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTAVMMLRYIDEFETAETIEQ
ALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGRRSATWKTRPYQPIRIPAQRPELDPVRPSRRRVVGVDLIVEGT
EPPQILGPNLERLIDDLPLRLHLISSRGLQVYPDVGTTIDYVDHWRCRFLSHDGEVSTATVTALLERLSARYRWSRVQLL
HEFDGEPGFTRAQGED

Sequences:

>Translated_496_residues
MEQSGGSGATMKYVVTPNGKKLVTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRAGASVFREGIASGVPDDTIESIKR
TRVVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRGRNIDLVVVRENIEDLYAAIEYRETPGVTIAH
KLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEV
IVTTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTAVMMLRYIDEFETAETIEQ
ALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGRRSATWKTRPYQPIRIPAQRPELDPVRPSRRRVVGVDLIVEGT
EPPQILGPNLERLIDDLPLRLHLISSRGLQVYPDVGTTIDYVDHWRCRFLSHDGEVSTATVTALLERLSARYRWSRVQLL
HEFDGEPGFTRAQGED
>Mature_496_residues
MEQSGGSGATMKYVVTPNGKKLVTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRAGASVFREGIASGVPDDTIESIKR
TRVVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRGRNIDLVVVRENIEDLYAAIEYRETPGVTIAH
KLISYKGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEV
IVTTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTAVMMLRYIDEFETAETIEQ
ALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGRRSATWKTRPYQPIRIPAQRPELDPVRPSRRRVVGVDLIVEGT
EPPQILGPNLERLIDDLPLRLHLISSRGLQVYPDVGTTIDYVDHWRCRFLSHDGEVSTATVTALLERLSARYRWSRVQLL
HEFDGEPGFTRAQGED

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=335, Percent_Identity=43.8805970149254, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4758582, Length=337, Percent_Identity=37.3887240356083, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI28178838, Length=313, Percent_Identity=38.3386581469649, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI28178821, Length=339, Percent_Identity=37.7581120943953, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI28178816, Length=339, Percent_Identity=37.7581120943953, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI28178819, Length=205, Percent_Identity=41.4634146341463, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1787381, Length=409, Percent_Identity=33.7408312958435, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788101, Length=325, Percent_Identity=33.8461538461538, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87081683, Length=358, Percent_Identity=33.5195530726257, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71986051, Length=334, Percent_Identity=45.5089820359281, Blast_Score=277, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI25144293, Length=331, Percent_Identity=40.1812688821752, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17550882, Length=345, Percent_Identity=38.5507246376812, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17505779, Length=326, Percent_Identity=38.0368098159509, Blast_Score=214, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6324709, Length=352, Percent_Identity=43.1818181818182, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324291, Length=341, Percent_Identity=40.7624633431085, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322097, Length=354, Percent_Identity=35.0282485875706, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=30.1939058171745, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24643270, Length=339, Percent_Identity=42.7728613569322, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24643268, Length=339, Percent_Identity=42.7728613569322, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=41.5204678362573, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI161078633, Length=347, Percent_Identity=37.1757925072046, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24650122, Length=347, Percent_Identity=37.1757925072046, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI161078637, Length=347, Percent_Identity=37.1757925072046, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI281362242, Length=339, Percent_Identity=40.7079646017699, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24648872, Length=339, Percent_Identity=40.7079646017699, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161078635, Length=336, Percent_Identity=37.797619047619, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI161078639, Length=346, Percent_Identity=36.7052023121387, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI20130355, Length=358, Percent_Identity=27.3743016759777, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45550436, Length=267, Percent_Identity=22.0973782771536, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 54741; Mature: 54741

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQSGGSGATMKYVVTPNGKKLVTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRAGAS
CCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHH
VFREGIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVREL
HHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHC
PSVPTPYRGRNIDLVVVRENIEDLYAAIEYRETPGVTIAHKLISYKGSEKIIRFAFELAR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
AEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEV
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCEEE
IVTTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMIL
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
TAVMMLRYIDEFETAETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGRRS
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
ATWKTRPYQPIRIPAQRPELDPVRPSRRRVVGVDLIVEGTEPPQILGPNLERLIDDLPLR
CCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHCCCCHHHHHHCCCEE
LHLISSRGLQVYPDVGTTIDYVDHWRCRFLSHDGEVSTATVTALLERLSARYRWSRVQLL
EEEECCCCCEEECCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HEFDGEPGFTRAQGED
HHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEQSGGSGATMKYVVTPNGKKLVTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRAGAS
CCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHH
VFREGIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVREL
HHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHC
PSVPTPYRGRNIDLVVVRENIEDLYAAIEYRETPGVTIAHKLISYKGSEKIIRFAFELAR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
AEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEV
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCEEE
IVTTNLNGDIISDLASGLVGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMIL
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
TAVMMLRYIDEFETAETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGRRS
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
ATWKTRPYQPIRIPAQRPELDPVRPSRRRVVGVDLIVEGTEPPQILGPNLERLIDDLPLR
CCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHCCCCHHHHHHCCCEE
LHLISSRGLQVYPDVGTTIDYVDHWRCRFLSHDGEVSTATVTALLERLSARYRWSRVQLL
EEEECCCCCEEECCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HEFDGEPGFTRAQGED
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]