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The map label for this gene is tmk

Identifier: 221632235

GI number: 221632235

Start: 206419

End: 207051

Strand: Reverse

Name: tmk

Synonym: trd_0201

Alternate gene names: 221632235

Gene position: 207051-206419 (Counterclockwise)

Preceding gene: 221632236

Following gene: 221632234

Centisome position: 10.34

GC content: 64.45

Gene sequence:

>633_bases
GTGAGTTGGTTCATCACCTTCGAGGGACCGGAAGGAGCAGGCAAGACGACACAATGCGCTCTTTTGGCTGCCCGGCTCCG
CGAAGCTGGTTATTCCCTTCTCGTCACGCGAGAACCGGGTGGTACACCGCTCGGCGAAACCATCCGCGAGTGGCTTCTGG
CTGGCGAGGCACTTCGCCCGGAAACGGAAGCCCTGCTCTTCACCGCTGCCCGGGCTGAGCACGTGTGGGATCGGATCCGG
CCCGCCCTGGAACGCGGCACCATCGTCCTGTGTGACCGTTATGTCGATTCCACGTTGGCCTATCAGGGAGCTGGGCGCGG
TCTGGACGAAGGATGGCTCCGCGAGTTGCATCGGATCGCAACGGGCGACTTGTGGCCCGATCTGACGATCCTGCTGGATG
TTCCAGTGGAAGTCGGCCTGGCTCGCCGCCGGGCTGCCGCCGCGACGATCACGCGGCTCGATCAGGAAGAACTCGCCTTC
CACCGACGGGTCCGCGCTTGGTACCATGCCGCTGCACAGCGCGACCCCCAGCGCTGGCGTGTCGTCGATGCGACATTGCC
GCCTGAGGTTGTCGCCGACGCCGTCTGGGCAACCGTGACGGAAGTCATGAAACGGGGAAGACGTTCACCATGA

Upstream 100 bases:

>100_bases
GCCTCCAGCATCAGCTCGCCGAGCGGTACAACCTGGCATCCCGCAGCCGCGGGCGAGAGCCCTTCCGCCGGGTCGAAATC
TACCGCGAGGACGAGAGCTG

Downstream 100 bases:

>100_bases
CGGCCCCCTCGAAGCTCGTGATCGCCGTCGTCCAGGCACGCGATGCCGACAGGCTGCTCGATGCGCTCCAGCACGAGGGA
TTCCGCGCGACCCGGATTAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSWFITFEGPEGAGKTTQCALLAARLREAGYSLLVTREPGGTPLGETIREWLLAGEALRPETEALLFTAARAEHVWDRIR
PALERGTIVLCDRYVDSTLAYQGAGRGLDEGWLRELHRIATGDLWPDLTILLDVPVEVGLARRRAAAATITRLDQEELAF
HRRVRAWYHAAAQRDPQRWRVVDATLPPEVVADAVWATVTEVMKRGRRSP

Sequences:

>Translated_210_residues
MSWFITFEGPEGAGKTTQCALLAARLREAGYSLLVTREPGGTPLGETIREWLLAGEALRPETEALLFTAARAEHVWDRIR
PALERGTIVLCDRYVDSTLAYQGAGRGLDEGWLRELHRIATGDLWPDLTILLDVPVEVGLARRRAAAATITRLDQEELAF
HRRVRAWYHAAAQRDPQRWRVVDATLPPEVVADAVWATVTEVMKRGRRSP
>Mature_209_residues
SWFITFEGPEGAGKTTQCALLAARLREAGYSLLVTREPGGTPLGETIREWLLAGEALRPETEALLFTAARAEHVWDRIRP
ALERGTIVLCDRYVDSTLAYQGAGRGLDEGWLRELHRIATGDLWPDLTILLDVPVEVGLARRRAAAATITRLDQEELAFH
RRVRAWYHAAAQRDPQRWRVVDATLPPEVVADAVWATVTEVMKRGRRSP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=43.9024390243902, Blast_Score=141, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_THERP (B9KXL4)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002521456.1
- GeneID:   7355223
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_0201
- OMA:   LFITLEG
- ProtClustDB:   CLSK2807437
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23532; Mature: 23401

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWFITFEGPEGAGKTTQCALLAARLREAGYSLLVTREPGGTPLGETIREWLLAGEALRP
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
ETEALLFTAARAEHVWDRIRPALERGTIVLCDRYVDSTLAYQGAGRGLDEGWLRELHRIA
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TGDLWPDLTILLDVPVEVGLARRRAAAATITRLDQEELAFHRRVRAWYHAAAQRDPQRWR
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEE
VVDATLPPEVVADAVWATVTEVMKRGRRSP
EEECCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SWFITFEGPEGAGKTTQCALLAARLREAGYSLLVTREPGGTPLGETIREWLLAGEALRP
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
ETEALLFTAARAEHVWDRIRPALERGTIVLCDRYVDSTLAYQGAGRGLDEGWLRELHRIA
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TGDLWPDLTILLDVPVEVGLARRRAAAATITRLDQEELAFHRRVRAWYHAAAQRDPQRWR
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEE
VVDATLPPEVVADAVWATVTEVMKRGRRSP
EEECCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA