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The map label for this gene is ygcA [C]

Identifier: 221232637

GI number: 221232637

Start: 1873080

End: 1874423

Strand: Reverse

Name: ygcA [C]

Synonym: SPN23F_19230

Alternate gene names: 221232637

Gene position: 1874423-1873080 (Counterclockwise)

Preceding gene: 221232640

Following gene: 221232634

Centisome position: 84.38

GC content: 37.95

Gene sequence:

>1344_bases
GTGAAACAAAAAATACCATTAAAAATCAAGCGCATGGGAATTAACGGTGAGGGAATCGGCTTTTACCAAAAAACATTAGT
CTTTGTACCAGGAGCTCTCAAAGGCGAAGATATCTATTGTCAGATTACTTCTATTAGACGCAACTTTGTTGAAGCAAAAT
TACTGAAGGTCAACAAGAAGTCTAAATTTCGAATTGTGCCATCTTGTACTATTTATAATGAATGCGGAGGCTGCCAAATC
ATGCACCTGCATTATGATAAGCAGCTGGAGTTCAAGACGGACTTACTTCATCAAGCGCTGAAAAAATTTGCTCCTGCAGG
ATATGAAAATTATGAAATTCGTCCAACTATTGGAATGCAGGAACCAAAATATTACAGAGCTAAGTTACAATTTCAGACTC
GAAAATTTAAAAATCAGGTCAAGGCGGGCTTATATGCACAAAACTCTCACTATTTAGTAGAGTTGAAAGACTGCCTGGTA
CAAGATAAGGAAACCCAAGTGATTGCTAATCGCTTAGCAGAATTACTTACTTATCACCAGATTCCAATCACGGATGAGAG
AAAAGTTCTAGGTGTCCGTACTATTATGGTCCGACGCGCGAGAAAGACCGGACAGGTTCAGATTATTATTGTTACAAACC
GCCAGCTTAATTTAACTCAATTGGTAAAAGAGTTGGTTAAAGATTTCCCAGAAGTTGTGACAGTAGCTGTTAATACAAAT
ACAGCTAAAACCAGTGAGATATATGGTGAAAAGACAGAGATTATCTGGGGGCAAGAGAGTATTCAAGAAGGTGTACTCAA
TTATGAATTTTCACTATCCCCTCGAGCTTTTTATCAACTAAATCCTGAGCAAACAGAAGTCCTCTATAGCGAAGCAGTAA
AAGCGCTGGATGTTGATAAAGAAGACCATTTGATTGACGCTTATTGTGGAGTTGGAACGATTGGATTTGCCTTTGCAAAG
AAAGTTAAAACACTCAGAGGTATGGATATTATTCCAGAAGCTATTGAAGATGCCAAGCGAAATGCTAAAAGAATGGGATT
TGACAATACTCATTATGAAGCTGGAACGGCAGAAGAGATTATTCCTCGTTGGTACAAGGAAGGCTACCGAGCAGATGCTT
TGATTGTTGACCCACCACGTACAGGTCTGGATGATAAGTTATTAGATACTATTCTTACTTATGTACCAGAAAAAATGGTT
TATATTTCTTGTAATGTTTCGACCTTGGCTCGTGATTTGGTACGCTTAGTAGAAGTCTATGATCTTCATTATATCCAGTC
GGTCGATATGTTCCCACATACAGCTCGAACTGAAGCTGTTGTAAAATTAATAAAAAAAGTTTAA

Upstream 100 bases:

>100_bases
AAGCTCCATCAGGTAGAGTCTTTTTTTCTTTTCAAGTTTTGTGATTTTCATAGCTCTATTATAACTCAAAATGTGATAAG
ATAGGGGTATGAATCTGAAA

Downstream 100 bases:

>100_bases
AAAAGTAGTTGACAAAGTTTGAAAAGGCTGTATAATAGTAAGAGTTGAAAATAACAACTCAGGTCCGTTGGTCAAGGGGT
TAAGACACCGCCTTTTCACG

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYCQITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQI
MHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELKDCLV
QDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLVKELVKDFPEVVTVAVNTN
TAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAK
KVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLLDTILTYVPEKMV
YISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKKV

Sequences:

>Translated_447_residues
MKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYCQITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQI
MHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELKDCLV
QDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLVKELVKDFPEVVTVAVNTN
TAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAK
KVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLLDTILTYVPEKMV
YISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKKV
>Mature_447_residues
MKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYCQITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQI
MHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELKDCLV
QDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLVKELVKDFPEVVTVAVNTN
TAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAK
KVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLLDTILTYVPEKMV
YISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKKV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=210, Percent_Identity=32.3809523809524, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI51173878, Length=210, Percent_Identity=32.3809523809524, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI269784680, Length=277, Percent_Identity=27.0758122743682, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI269784676, Length=277, Percent_Identity=27.0758122743682, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI20149688, Length=277, Percent_Identity=27.0758122743682, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI269784678, Length=277, Percent_Identity=27.0758122743682, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1789148, Length=453, Percent_Identity=26.0485651214128, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787083, Length=384, Percent_Identity=25, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790403, Length=166, Percent_Identity=28.9156626506024, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71997438, Length=193, Percent_Identity=26.9430051813472, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322909, Length=432, Percent_Identity=23.1481481481481, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24666579, Length=422, Percent_Identity=26.7772511848341, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51288; Mature: 51288

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYCQITSIRRNFVEAKLLKVNKK
CCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHEECCC
SKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQ
CCEEEEECEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
EPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELKDCLVQDKETQVIANRLAELLTYHQ
CCHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHCC
IPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLVKELVKDFPEVVTVAVNTN
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHEEEEEECC
TAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALDVDK
CCCHHHHCCCCEEEEECHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCC
EDHLIDAYCGVGTIGFAFAKKVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEI
CCCEEEHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
IPRWYKEGYRADALIVDPPRTGLDDKLLDTILTYVPEKMVYISCNVSTLARDLVRLVEVY
HHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHH
DLHYIQSVDMFPHTARTEAVVKLIKKV
HHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYCQITSIRRNFVEAKLLKVNKK
CCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHEECCC
SKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQALKKFAPAGYENYEIRPTIGMQ
CCEEEEECEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
EPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELKDCLVQDKETQVIANRLAELLTYHQ
CCHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHCC
IPITDERKVLGVRTIMVRRARKTGQVQIIIVTNRQLNLTQLVKELVKDFPEVVTVAVNTN
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHEEEEEECC
TAKTSEIYGEKTEIIWGQESIQEGVLNYEFSLSPRAFYQLNPEQTEVLYSEAVKALDVDK
CCCHHHHCCCCEEEEECHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCC
EDHLIDAYCGVGTIGFAFAKKVKTLRGMDIIPEAIEDAKRNAKRMGFDNTHYEAGTAEEI
CCCEEEHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
IPRWYKEGYRADALIVDPPRTGLDDKLLDTILTYVPEKMVYISCNVSTLARDLVRLVEVY
HHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHH
DLHYIQSVDMFPHTARTEAVVKLIKKV
HHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11544234 [H]