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The map label for this gene is trpC [H]

Identifier: 221232558

GI number: 221232558

Start: 1780121

End: 1780888

Strand: Reverse

Name: trpC [H]

Synonym: SPN23F_18340

Alternate gene names: 221232558

Gene position: 1780888-1780121 (Counterclockwise)

Preceding gene: 221232559

Following gene: 221232557

Centisome position: 80.17

GC content: 46.74

Gene sequence:

>768_bases
ATGAGTCAGGAATTTTTAGCACGAATCTTAGAGCAGAAGGCGCGTGAGGTGGAGCAGATGAAGCTGGAGCAAATCCAGCC
TCTGCGCCAGACCTATCGCTTGGCAGAATTTTTGAAGAATCATCAGGACCGCTTGCAGGTAATCGCTGAGGTCAAGAAAG
CTAGCCCTAGTTTGGGAGATATCAATCTCGATGTGGATATTGTGCAACAGGCCCAGACTTATGAAGAAAACGGAGCAGTG
ATGATTTCGGTGTTGACAGATGAGGTTTTCTTTAAAGGGCATTTGGATTATCTACGGGAAATTTCCAGTCAGGTAGAGAT
TCCGACGCTCAACAAAGACTTTATCATAGATGAAAAGCAAATCATCCGCGCTCGCAATGCAGGTGCGACAGTTATCTTGC
TTATTGTGGCAGCCTTGTCCGAAGAACGCCTCAAGGAACTGTATGACTACGCGACAGAGCTTGGTCTGGAAGTCTTAGTG
GAGACTCACAATCTAGCTGAACTAGAGGTAGCCCACAGACTTGGTGCTGAGATTATCGGGGTCAACAACCGCAACTTGAC
TACCTTTGAGGTCGACTTGCAGACCAGTGTAGATTTAGCCCCTTACTTTGAGGAAGGTCGCTATTACATTTCTGAATCTG
CCATTTTCACAGGGCAGGATGCGGAACGACTAGCCCCATACTTTAACGGAATTTTGGTAGGGACAGCTCTTATGCAGGCA
GAAAATGTGGCCCAGAGAATCAAGGAGTTGCAGATTGACAAAGGTTAA

Upstream 100 bases:

>100_bases
GTAAGATTGATAGCATCAAGGAAGGAGTTGCCTTGGCCCGTCAAGTGATTGCTAGAGGCAAGGCCCTTGAAAAACTCAGA
CTGTTACAGGAGTACCAAAA

Downstream 100 bases:

>100_bases
AATTTGTGGACTATCGACCAAAGAAGCGGTGGAAACAGCCGTTTCAGCAGGAGCCGACTATATCGGTTTTGTCTTTGCAC
CTAGTAAAAGACAGGTGACT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAV
MISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
ENVAQRIKELQIDKG

Sequences:

>Translated_255_residues
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAV
MISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
ENVAQRIKELQIDKG
>Mature_254_residues
SQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVM
ISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVE
THNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQAE
NVAQRIKELQIDKG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=256, Percent_Identity=36.71875, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=38.8888888888889, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28940; Mature: 28809

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
INLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQ
CCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
IIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVETHNLAELEVAHRLGAEIIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
VNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
CCCCCEEEEEEEECCCCCCCHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHH
ENVAQRIKELQIDKG
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
INLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQ
CCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
IIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVETHNLAELEVAHRLGAEIIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
VNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
CCCCCEEEEEEEECCCCCCCHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHH
ENVAQRIKELQIDKG
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA