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The map label for this gene is gcvPA

Identifier: 220933174

GI number: 220933174

Start: 2560099

End: 2561442

Strand: Reverse

Name: gcvPA

Synonym: Hore_23420

Alternate gene names: 220933174

Gene position: 2561442-2560099 (Counterclockwise)

Preceding gene: 220933175

Following gene: 220933173

Centisome position: 99.35

GC content: 45.46

Gene sequence:

>1344_bases
TTGGATTATATCTCCAATACCCCTTCTGAGAAAGAGGCTATGCTAAAAAAAATAGGTGTAGAAAATGTTGAGGACCTCTT
TAAACCCATTCCTGATGATGTTACCTTTAAACGGCCCTTTAATATTCCCCCGGGCCTGTCTGAACTTGAGCTGAAACGGA
TGATAAAGAGTAAAGCTGCCCGGAATATAAGTATGGAAGAACAGATCTGCTTTGCCGGGGGAGGGGCTTATGACCATTAT
ATTCCGGCTCATATCGACCACCTAATATCCAGGTCTGAGTTTTATACTGCCTATACTCCCTATCAGGCAGAATTGAGTCA
GGGGGTCCTCCAGGCCATGTATGAATACCAGAGTATGATCTGTGAGCTTACCGGAATGGAGGTAGCCAACTCTTCTTTGC
TCGATGGCGGGTCTGCGACTGGAGAGGCTGTTCTGATGGCTTCAAGAATTAGCCGGAAGAAGAAAATCCTGATGTCAAGG
GGTATAAACCCGGTTTACCGTGAAGTTGCCAGGACATATGGCAGACCCCGGGGGCTGGAGTTTATTGATCTGGGCCTGAA
TGAAACGGTGACTGACATGGAAGAGCTGGAACAAAAGCTTGATGAAGATACCGGGGCTGTTGTTCTTCAGTACCCCAACT
TTTTCGGGTCAATTGAAGACCTCAATGTTGTTAAAAACCTGATTTCAGCACGGAAACGAACCCTGTTAATTATAGTAGTT
AACCCCTTAACCCTGGGGGTTTTAAAACCACCAGCTGAGTTTGGAGCCGATATTGTTGTCGGTGAGGGCCAGGTTCTGGG
TAATCCCATTAATTACGGGGGACCATATCTGGGGATTATGGCTACCAGGAAAAGATATGTAAGACAGATGCCGGGGCGGA
TTGTAGGGGCAACAACAGATTCTGATGGTAAGAGGGGTTATGTTTTGACTCTCCAGACCAGAGAGCAGCATATCCGCCGG
GCCAGGGCTACCTCCAATATCTGTACCAATGAAGCCCTCAATGCCCTGACAGCTGCTATTTACATGGCAACAATGGGTAA
AAAAGGTATTAAAGAGGTAGGCGAACAATCCTTTAAAAAAGCCCACTATATGGCTGATAGGATAGATGATATGGAGGGTT
TTGAAGTGGTTAATAAAGATAACTTTTTCCATGAGTTTGTAATTAAAACCCCCCTGCCATCTGCTGAAATTGGTGAAAGA
CTTAAAAGAAAAGGAATACTGGGTGGCCTAGATGTCTCCCGCTGGTATTCTTTTGATGGTTTTCTGGTATGTACGACTGA
AAAAAGGACCAGGGAAGAAATAGATGGGTATCTGGAGGCCCTGGAGGTGATATCCAGTGATTGA

Upstream 100 bases:

>100_bases
TCAGGATGGCTTGTTAAGATAAAGCTGGCCGACAAAAAGGAGCTTGAAGACCTTATGAGTAGTGAAGAATATGCCAGATA
CCTGGAGGAGGTAGAATAAG

Downstream 100 bases:

>100_bases
ACCACTTATTAAAGATTACAGCAGTCAGGGCCGGAAGGGTTATTCCCTGCCCGAACTTGATGTACCCGATATAGATGTTA
AAGAGTATTTAAAAGAGGGT

Product: glycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDYISNTPSEKEAMLKKIGVENVEDLFKPIPDDVTFKRPFNIPPGLSELELKRMIKSKAARNISMEEQICFAGGGAYDHY
IPAHIDHLISRSEFYTAYTPYQAELSQGVLQAMYEYQSMICELTGMEVANSSLLDGGSATGEAVLMASRISRKKKILMSR
GINPVYREVARTYGRPRGLEFIDLGLNETVTDMEELEQKLDEDTGAVVLQYPNFFGSIEDLNVVKNLISARKRTLLIIVV
NPLTLGVLKPPAEFGADIVVGEGQVLGNPINYGGPYLGIMATRKRYVRQMPGRIVGATTDSDGKRGYVLTLQTREQHIRR
ARATSNICTNEALNALTAAIYMATMGKKGIKEVGEQSFKKAHYMADRIDDMEGFEVVNKDNFFHEFVIKTPLPSAEIGER
LKRKGILGGLDVSRWYSFDGFLVCTTEKRTREEIDGYLEALEVISSD

Sequences:

>Translated_447_residues
MDYISNTPSEKEAMLKKIGVENVEDLFKPIPDDVTFKRPFNIPPGLSELELKRMIKSKAARNISMEEQICFAGGGAYDHY
IPAHIDHLISRSEFYTAYTPYQAELSQGVLQAMYEYQSMICELTGMEVANSSLLDGGSATGEAVLMASRISRKKKILMSR
GINPVYREVARTYGRPRGLEFIDLGLNETVTDMEELEQKLDEDTGAVVLQYPNFFGSIEDLNVVKNLISARKRTLLIIVV
NPLTLGVLKPPAEFGADIVVGEGQVLGNPINYGGPYLGIMATRKRYVRQMPGRIVGATTDSDGKRGYVLTLQTREQHIRR
ARATSNICTNEALNALTAAIYMATMGKKGIKEVGEQSFKKAHYMADRIDDMEGFEVVNKDNFFHEFVIKTPLPSAEIGER
LKRKGILGGLDVSRWYSFDGFLVCTTEKRTREEIDGYLEALEVISSD
>Mature_447_residues
MDYISNTPSEKEAMLKKIGVENVEDLFKPIPDDVTFKRPFNIPPGLSELELKRMIKSKAARNISMEEQICFAGGGAYDHY
IPAHIDHLISRSEFYTAYTPYQAELSQGVLQAMYEYQSMICELTGMEVANSSLLDGGSATGEAVLMASRISRKKKILMSR
GINPVYREVARTYGRPRGLEFIDLGLNETVTDMEELEQKLDEDTGAVVLQYPNFFGSIEDLNVVKNLISARKRTLLIIVV
NPLTLGVLKPPAEFGADIVVGEGQVLGNPINYGGPYLGIMATRKRYVRQMPGRIVGATTDSDGKRGYVLTLQTREQHIRR
ARATSNICTNEALNALTAAIYMATMGKKGIKEVGEQSFKKAHYMADRIDDMEGFEVVNKDNFFHEFVIKTPLPSAEIGER
LKRKGILGGLDVSRWYSFDGFLVCTTEKRTREEIDGYLEALEVISSD

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=352, Percent_Identity=35.2272727272727, Blast_Score=222, Evalue=5e-58,
Organism=Escherichia coli, GI1789269, Length=359, Percent_Identity=31.7548746518106, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=381, Percent_Identity=37.007874015748, Blast_Score=224, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=461, Percent_Identity=33.1887201735358, Blast_Score=236, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24645648, Length=395, Percent_Identity=37.9746835443038, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_HALOH (B8D1D5)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002510082.1
- ProteinModelPortal:   B8D1D5
- SMR:   B8D1D5
- GeneID:   7314225
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_23420
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49917; Mature: 49917

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYISNTPSEKEAMLKKIGVENVEDLFKPIPDDVTFKRPFNIPPGLSELELKRMIKSKAA
CCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHH
RNISMEEQICFAGGGAYDHYIPAHIDHLISRSEFYTAYTPYQAELSQGVLQAMYEYQSMI
CCCCHHHCEEEECCCCCCCCCHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHH
CELTGMEVANSSLLDGGSATGEAVLMASRISRKKKILMSRGINPVYREVARTYGRPRGLE
HHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCE
FIDLGLNETVTDMEELEQKLDEDTGAVVLQYPNFFGSIEDLNVVKNLISARKRTLLIIVV
EEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEE
NPLTLGVLKPPAEFGADIVVGEGQVLGNPINYGGPYLGIMATRKRYVRQMPGRIVGATTD
CCCEEECCCCHHHHCCEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
SDGKRGYVLTLQTREQHIRRARATSNICTNEALNALTAAIYMATMGKKGIKEVGEQSFKK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AHYMADRIDDMEGFEVVNKDNFFHEFVIKTPLPSAEIGERLKRKGILGGLDVSRWYSFDG
HHHHHHHHCCCCCCEEECCCCCEEHEEEECCCCCHHHHHHHHHCCCCCCCCHHHHCCCCC
FLVCTTEKRTREEIDGYLEALEVISSD
EEEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDYISNTPSEKEAMLKKIGVENVEDLFKPIPDDVTFKRPFNIPPGLSELELKRMIKSKAA
CCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHH
RNISMEEQICFAGGGAYDHYIPAHIDHLISRSEFYTAYTPYQAELSQGVLQAMYEYQSMI
CCCCHHHCEEEECCCCCCCCCHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHH
CELTGMEVANSSLLDGGSATGEAVLMASRISRKKKILMSRGINPVYREVARTYGRPRGLE
HHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCE
FIDLGLNETVTDMEELEQKLDEDTGAVVLQYPNFFGSIEDLNVVKNLISARKRTLLIIVV
EEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEE
NPLTLGVLKPPAEFGADIVVGEGQVLGNPINYGGPYLGIMATRKRYVRQMPGRIVGATTD
CCCEEECCCCHHHHCCEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
SDGKRGYVLTLQTREQHIRRARATSNICTNEALNALTAAIYMATMGKKGIKEVGEQSFKK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AHYMADRIDDMEGFEVVNKDNFFHEFVIKTPLPSAEIGERLKRKGILGGLDVSRWYSFDG
HHHHHHHHCCCCCCEEECCCCCEEHEEEECCCCCHHHHHHHHHCCCCCCCCHHHHCCCCC
FLVCTTEKRTREEIDGYLEALEVISSD
EEEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA