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The map label for this gene is rkpK [H]

Identifier: 220933109

GI number: 220933109

Start: 2485332

End: 2486714

Strand: Reverse

Name: rkpK [H]

Synonym: Hore_22770

Alternate gene names: 220933109

Gene position: 2486714-2485332 (Counterclockwise)

Preceding gene: 220933110

Following gene: 220933108

Centisome position: 96.45

GC content: 46.06

Gene sequence:

>1383_bases
ATGTACGAAAATAAAATAAGTGTCATCGGAACAGGTTATGTAGGCCTGGTCAGTGGAGTCTGTCTGGCTGACTTCGGTAA
TACTGTTATCAATGTTGACATTGATGAAGAAAAGATTAACAAACTTAATAATGGTGAAGTTCCCATTTATGAGCCTGGAC
TTTCAGAATATCTACAGAGAAACTTTGAATCAGGCAGGATATCCTTTACCACAGATGTAAAAGAGGCCATCGAGAATTCA
GGGGTTGTCTTTATTGCGGTAGGTACTCCTCCAAAGGATGATGGGAGTGCTGACCTGCAGTATGTTCTTTCGGTAGCCCG
GGATATCGGTAAATATATGAATGGCTATAAAGTCATAGTGGACAAGTCTACTGTGCCCATCGGTACTGGACGGAAGGTAG
CGGCCGTTATCCAGGAGGAGCTGGACAAACGCGGGGTGGACTATAAGTTTGATGTTGTCAGCAATCCCGAATTTTTAAGG
GAGGGTAAGGCTGTTTATGATTTTACCCACCCCGACAGGGTGGTTATCGGGACCGAGAGTGAAAAGGCCCGTGATATATT
AAAAGAAGTATACCGTGCTTTATACTTAAATGATACTCCCTTTGTCTTTACCAACCTGGAGACAGCTGAAATGATAAAAT
ATGCCTCAAATGCCTTTCTGGCCACCAAGATTTCCTTTATTAACGAGATCTCGGTTCTATGTGAAAAGGTCAATGCCGAT
GTTCAGGTGGTGGCTAAAGCCATGGGTATGGACGGCCGTATCGGGGATAAATTCCTTCACGCCGGGCCCGGATATGGAGG
AAGCTGTTTCCCCAAAGATACCAGGGCCATTGTCAGGATTGCTGCTGAAAACGGGGTTGATCTCAAGGTTATTAAGGCCG
GAATTGAGGCCAATGAAAATCAGAAGCTATACATGGTAGAAAAGATTGTAAATAAGCTGGGAGACCTCAAGGGTAAGACC
CTGGGTATTCTTGGTCTTAGCTTTAAACCGGAAACAGATGATATGCGTGAAGCTCCGGCCCTGACCATTATTCCCGAACT
CATAAAACGGGGAGCCCGGATAAGGGCCTTTGACCCCGAGGGCATAAAAGAGGCCACCTGGCGGTTAAAGGATTATGAAA
AAGATATTATCTACTGTGATAATGAGTATGAGGTTATGAAGGGGTCCAATGCCCTTGTTTTACTCACTGAATGGAACCAG
TTCCGCCGGCTTGACCTGAAGAGGGTGAAAGAGCTTCTTGCTGATCCCGTTTTCTTCGACCTGAGGAATGTCTATGAAGT
AGAGGAAGTGGAAAAGGTCGGCCTTGAATATATCGGGGTCGGTACTGCCCAGAAAGCCGACGCTGAGGCCTTTAAAGAGG
CTGCAGCGGCCCGGGAGGAGTAA

Upstream 100 bases:

>100_bases
CTTTTATTAATCATAGTATATGTTTATTTGCTAAAGTGCTCTAAATATATTATCATAAACATATAAGTGAATAATTTAAC
AAGGTACTGGAGGGGTTAAG

Downstream 100 bases:

>100_bases
CACCGGAAGTTATCCGGGGGTAAAGCAGGGCCAGGTAATATAAATAGATTAACAAAAGTTTAATAATAGATTTGAATAAT
CCCTGACTGGATTTTATCCG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MYENKISVIGTGYVGLVSGVCLADFGNTVINVDIDEEKINKLNNGEVPIYEPGLSEYLQRNFESGRISFTTDVKEAIENS
GVVFIAVGTPPKDDGSADLQYVLSVARDIGKYMNGYKVIVDKSTVPIGTGRKVAAVIQEELDKRGVDYKFDVVSNPEFLR
EGKAVYDFTHPDRVVIGTESEKARDILKEVYRALYLNDTPFVFTNLETAEMIKYASNAFLATKISFINEISVLCEKVNAD
VQVVAKAMGMDGRIGDKFLHAGPGYGGSCFPKDTRAIVRIAAENGVDLKVIKAGIEANENQKLYMVEKIVNKLGDLKGKT
LGILGLSFKPETDDMREAPALTIIPELIKRGARIRAFDPEGIKEATWRLKDYEKDIIYCDNEYEVMKGSNALVLLTEWNQ
FRRLDLKRVKELLADPVFFDLRNVYEVEEVEKVGLEYIGVGTAQKADAEAFKEAAAAREE

Sequences:

>Translated_460_residues
MYENKISVIGTGYVGLVSGVCLADFGNTVINVDIDEEKINKLNNGEVPIYEPGLSEYLQRNFESGRISFTTDVKEAIENS
GVVFIAVGTPPKDDGSADLQYVLSVARDIGKYMNGYKVIVDKSTVPIGTGRKVAAVIQEELDKRGVDYKFDVVSNPEFLR
EGKAVYDFTHPDRVVIGTESEKARDILKEVYRALYLNDTPFVFTNLETAEMIKYASNAFLATKISFINEISVLCEKVNAD
VQVVAKAMGMDGRIGDKFLHAGPGYGGSCFPKDTRAIVRIAAENGVDLKVIKAGIEANENQKLYMVEKIVNKLGDLKGKT
LGILGLSFKPETDDMREAPALTIIPELIKRGARIRAFDPEGIKEATWRLKDYEKDIIYCDNEYEVMKGSNALVLLTEWNQ
FRRLDLKRVKELLADPVFFDLRNVYEVEEVEKVGLEYIGVGTAQKADAEAFKEAAAAREE
>Mature_460_residues
MYENKISVIGTGYVGLVSGVCLADFGNTVINVDIDEEKINKLNNGEVPIYEPGLSEYLQRNFESGRISFTTDVKEAIENS
GVVFIAVGTPPKDDGSADLQYVLSVARDIGKYMNGYKVIVDKSTVPIGTGRKVAAVIQEELDKRGVDYKFDVVSNPEFLR
EGKAVYDFTHPDRVVIGTESEKARDILKEVYRALYLNDTPFVFTNLETAEMIKYASNAFLATKISFINEISVLCEKVNAD
VQVVAKAMGMDGRIGDKFLHAGPGYGGSCFPKDTRAIVRIAAENGVDLKVIKAGIEANENQKLYMVEKIVNKLGDLKGKT
LGILGLSFKPETDDMREAPALTIIPELIKRGARIRAFDPEGIKEATWRLKDYEKDIIYCDNEYEVMKGSNALVLLTEWNQ
FRRLDLKRVKELLADPVFFDLRNVYEVEEVEKVGLEYIGVGTAQKADAEAFKEAAAAREE

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=474, Percent_Identity=35.8649789029536, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI296040438, Length=371, Percent_Identity=35.5795148247978, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI296040443, Length=315, Percent_Identity=36.8253968253968, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788340, Length=386, Percent_Identity=30.3108808290155, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=28.5035629453682, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17560350, Length=466, Percent_Identity=34.9785407725322, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17136908, Length=467, Percent_Identity=35.5460385438972, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51127; Mature: 51127

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYENKISVIGTGYVGLVSGVCLADFGNTVINVDIDEEKINKLNNGEVPIYEPGLSEYLQR
CCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEEECHHHHHCCCCCCCEEECCCHHHHHHC
NFESGRISFTTDVKEAIENSGVVFIAVGTPPKDDGSADLQYVLSVARDIGKYMNGYKVIV
CCCCCCEEEEHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
DKSTVPIGTGRKVAAVIQEELDKRGVDYKFDVVSNPEFLREGKAVYDFTHPDRVVIGTES
ECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCEEEECCCCCEEEEECCC
EKARDILKEVYRALYLNDTPFVFTNLETAEMIKYASNAFLATKISFINEISVLCEKVNAD
HHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
VQVVAKAMGMDGRIGDKFLHAGPGYGGSCFPKDTRAIVRIAAENGVDLKVIKAGIEANEN
HHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCC
QKLYMVEKIVNKLGDLKGKTLGILGLSFKPETDDMREAPALTIIPELIKRGARIRAFDPE
CEEEHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHCCCHHHHHHHHHCCCEEEEECCC
GIKEATWRLKDYEKDIIYCDNEYEVMKGSNALVLLTEWNQFRRLDLKRVKELLADPVFFD
CHHHHHHHHHCCCCCEEEECCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHH
LRNVYEVEEVEKVGLEYIGVGTAQKADAEAFKEAAAAREE
HHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MYENKISVIGTGYVGLVSGVCLADFGNTVINVDIDEEKINKLNNGEVPIYEPGLSEYLQR
CCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEEECHHHHHCCCCCCCEEECCCHHHHHHC
NFESGRISFTTDVKEAIENSGVVFIAVGTPPKDDGSADLQYVLSVARDIGKYMNGYKVIV
CCCCCCEEEEHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
DKSTVPIGTGRKVAAVIQEELDKRGVDYKFDVVSNPEFLREGKAVYDFTHPDRVVIGTES
ECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCEEEECCCCCEEEEECCC
EKARDILKEVYRALYLNDTPFVFTNLETAEMIKYASNAFLATKISFINEISVLCEKVNAD
HHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
VQVVAKAMGMDGRIGDKFLHAGPGYGGSCFPKDTRAIVRIAAENGVDLKVIKAGIEANEN
HHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCC
QKLYMVEKIVNKLGDLKGKTLGILGLSFKPETDDMREAPALTIIPELIKRGARIRAFDPE
CEEEHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHCCCHHHHHHHHHCCCEEEEECCC
GIKEATWRLKDYEKDIIYCDNEYEVMKGSNALVLLTEWNQFRRLDLKRVKELLADPVFFD
CHHHHHHHHHCCCCCEEEECCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHH
LRNVYEVEEVEKVGLEYIGVGTAQKADAEAFKEAAAAREE
HHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]