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The map label for this gene is gyaR [H]

Identifier: 220933017

GI number: 220933017

Start: 2375056

End: 2375880

Strand: Reverse

Name: gyaR [H]

Synonym: Hore_21840

Alternate gene names: 220933017

Gene position: 2375880-2375056 (Counterclockwise)

Preceding gene: 220933018

Following gene: 220933016

Centisome position: 92.15

GC content: 45.09

Gene sequence:

>825_bases
ATGTTAAGTGACCCCATTGACGGGGGAGTAATTAAAAGCAACCCTGATCTGAAAGTGGTTGCCAACTATGCGGTAGGATA
TAACAATATTGATGTTGAAGCCGCTACCAGACAGGGGGTGGCTGTGACCAATACTCCCGGTGTTTTAACTGAAGCAACTG
CTGATTTGACCTGGGCTTTATTAATGGCTGTGGCCAGGCGGATAATAGAATCAGACCAGTTTGTAAGGCAGGGACAGTTT
AAAGGATGGGGACCGAGGTTAATGCTGGGAAGTGATGTTTATGGAAAAACACTGGGGATTATCGGTTTTGGCCGGATCGG
GCAGGCTGTGGCCAGACGGGCCCGGGGTTTTAATATGGAGATTCTTTATAATAAAAGAACCCGCCTTTCCCGGGACCGGG
AAGAAAAACTGGGAGTTCAGTATGCTGAGGTTGATGAATTGCTTAAGAGGGCAGATTATATCTCCATAAATGCTCCTTTG
AATAAGTCAACATACCATCTGGTTGGCCTGCAGGAATTTGAACTTATGAAAAATACTGCTATAGTTATAAATACCGGACG
GGGTCCAATAATAGATGAAAGTGCCCTGGTCGAGGCTTTAAAAGAGGGGAAAATAGCCGGGGCCGGCCTCGATGTTTATG
AAGAAGAACCAGAAGTACATCCGGGTCTTATGGAGCTTGATAATGTTGTGTTAACCCCTCACACCGGGAGTGGTACCATT
GAGACCAGGGATAAAATGGCGGTTATGGTGGCAGAAGATGTTATTGCTGTTTTAAAAGGAAAAAGACCAGCAAATTTGGT
TAATCCAGGAGTCTATAAGAATTGA

Upstream 100 bases:

>100_bases
ACTTGAAAAAGAATGTCATGTGACTGTTAACAGGAATAGCAGGAGTCTGGGAAGGGAGGAATTAATTAATAACATAAAAG
GAATCGACGGGTTGGTCTCT

Downstream 100 bases:

>100_bases
ATTGTATCCCCGGGATGACATGCTAAATTAAATAACTTAGGTTAAATTAAAGCAAGTCCTGACAGGGGCTTGCTTTATGT
AATATTTGGAATATATAAAA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MLSDPIDGGVIKSNPDLKVVANYAVGYNNIDVEAATRQGVAVTNTPGVLTEATADLTWALLMAVARRIIESDQFVRQGQF
KGWGPRLMLGSDVYGKTLGIIGFGRIGQAVARRARGFNMEILYNKRTRLSRDREEKLGVQYAEVDELLKRADYISINAPL
NKSTYHLVGLQEFELMKNTAIVINTGRGPIIDESALVEALKEGKIAGAGLDVYEEEPEVHPGLMELDNVVLTPHTGSGTI
ETRDKMAVMVAEDVIAVLKGKRPANLVNPGVYKN

Sequences:

>Translated_274_residues
MLSDPIDGGVIKSNPDLKVVANYAVGYNNIDVEAATRQGVAVTNTPGVLTEATADLTWALLMAVARRIIESDQFVRQGQF
KGWGPRLMLGSDVYGKTLGIIGFGRIGQAVARRARGFNMEILYNKRTRLSRDREEKLGVQYAEVDELLKRADYISINAPL
NKSTYHLVGLQEFELMKNTAIVINTGRGPIIDESALVEALKEGKIAGAGLDVYEEEPEVHPGLMELDNVVLTPHTGSGTI
ETRDKMAVMVAEDVIAVLKGKRPANLVNPGVYKN
>Mature_274_residues
MLSDPIDGGVIKSNPDLKVVANYAVGYNNIDVEAATRQGVAVTNTPGVLTEATADLTWALLMAVARRIIESDQFVRQGQF
KGWGPRLMLGSDVYGKTLGIIGFGRIGQAVARRARGFNMEILYNKRTRLSRDREEKLGVQYAEVDELLKRADYISINAPL
NKSTYHLVGLQEFELMKNTAIVINTGRGPIIDESALVEALKEGKIAGAGLDVYEEEPEVHPGLMELDNVVLTPHTGSGTI
ETRDKMAVMVAEDVIAVLKGKRPANLVNPGVYKN

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=265, Percent_Identity=36.2264150943396, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI23308577, Length=260, Percent_Identity=36.1538461538462, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=34.3629343629344, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=34.3629343629344, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=33.976833976834, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=33.5907335907336, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=34.3629343629344, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=44.2379182156134, Blast_Score=234, Evalue=3e-63,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=32.8125, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1788660, Length=240, Percent_Identity=26.25, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=244, Percent_Identity=31.9672131147541, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=30.5970149253731, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=38.2113821138211, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=261, Percent_Identity=30.6513409961686, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=257, Percent_Identity=29.9610894941634, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=281, Percent_Identity=26.3345195729537, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=164, Percent_Identity=33.5365853658537, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=183, Percent_Identity=29.5081967213115, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=224, Percent_Identity=26.3392857142857, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=40.2390438247012, Blast_Score=180, Evalue=7e-46,
Organism=Drosophila melanogaster, GI28571528, Length=264, Percent_Identity=41.2878787878788, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=37.2, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=37.2, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=37.2, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24585514, Length=251, Percent_Identity=36.6533864541833, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28574282, Length=251, Percent_Identity=36.6533864541833, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19921140, Length=252, Percent_Identity=38.8888888888889, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24585516, Length=266, Percent_Identity=29.6992481203008, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=33.0769230769231, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=33.0769230769231, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=33.0769230769231, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=33.0769230769231, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=33.0769230769231, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 29893; Mature: 29893

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDPIDGGVIKSNPDLKVVANYAVGYNNIDVEAATRQGVAVTNTPGVLTEATADLTWAL
CCCCCCCCCEEECCCCEEEEEEEEECCCCEEEEECCCCCEEEECCCCCEEHHHHHHHHHH
LMAVARRIIESDQFVRQGQFKGWGPRLMLGSDVYGKTLGIIGFGRIGQAVARRARGFNME
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEECEEECHHHHHHHHHHHCCCCEE
ILYNKRTRLSRDREEKLGVQYAEVDELLKRADYISINAPLNKSTYHLVGLQEFELMKNTA
EEECCCHHHCCCHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCEEEEECHHHHHHHCCCE
IVINTGRGPIIDESALVEALKEGKIAGAGLDVYEEEPEVHPGLMELDNVVLTPHTGSGTI
EEEECCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHCCEEEECCCCCCCE
ETRDKMAVMVAEDVIAVLKGKRPANLVNPGVYKN
ECCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSDPIDGGVIKSNPDLKVVANYAVGYNNIDVEAATRQGVAVTNTPGVLTEATADLTWAL
CCCCCCCCCEEECCCCEEEEEEEEECCCCEEEEECCCCCEEEECCCCCEEHHHHHHHHHH
LMAVARRIIESDQFVRQGQFKGWGPRLMLGSDVYGKTLGIIGFGRIGQAVARRARGFNME
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEECEEECHHHHHHHHHHHCCCCEE
ILYNKRTRLSRDREEKLGVQYAEVDELLKRADYISINAPLNKSTYHLVGLQEFELMKNTA
EEECCCHHHCCCHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCEEEEECHHHHHHHCCCE
IVINTGRGPIIDESALVEALKEGKIAGAGLDVYEEEPEVHPGLMELDNVVLTPHTGSGTI
EEEECCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHCCEEEECCCCCCCE
ETRDKMAVMVAEDVIAVLKGKRPANLVNPGVYKN
ECCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA