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The map label for this gene is degS [H]

Identifier: 220933016

GI number: 220933016

Start: 2373406

End: 2374581

Strand: Reverse

Name: degS [H]

Synonym: Hore_21830

Alternate gene names: 220933016

Gene position: 2374581-2373406 (Counterclockwise)

Preceding gene: 220933017

Following gene: 220933015

Centisome position: 92.1

GC content: 36.56

Gene sequence:

>1176_bases
GTGGGACAGAATATTGACCCGTCCAGATCTCTGGAAAAGATTCTTGAAAAGACAGTAGAAGTTTTAGCCGAGAGCAAGAA
GGAGATATTTACTATAGCCGAATCAATCCGCCGGGAATATGATAATATAAAGAGAGAACTAGATTTGATTAATGAGGAAA
TAAATGAAGTTGTAGCTAAAGTTGATAAGCTCCAGGAGGTTAACAGAATTGCGAGAATAAGGCTTATGGAAGTTAGCCGG
GATTTTGAAAAACATAGTGAATATGATATCAAATATGCCTATCAACAGGCTGAGGATACTTCTGTCCAGATAGCGGTATT
AAGGGAAAAAGAAGAACAGTTAAAGAAGAGAAGGGCCGAACTTGAAAACAGGTTAATTAATTTAAAAAGAAATATTGAAA
AGGCAGAAAATATGGTTTCCAGAGTAGGGGTTGTTCATGATTATTTACTTGGAGAATTATCCAATTTAAGTGAGCAATTT
GATGATTTAAGACAAAAACAACAGCTGGCCATTAAAATAATTCAGGCCCAGGAAGATGAACGGAAGAGGGTCGCCCGTGA
AATTCACGATGGACCGGCCCAGTCAATTGCCAATCTTGTCTTTAGAGTGGAACTTGCTCAGAAACTTATGGACAAGGATT
TAAAAAAGGCCAGGAATGAACTTGAGGATGTTAAAGAGCTGGTAAGATTAAGTATGCAGGAAGTCAGAAAAATTATTTAC
GACCTGAGGCCCATGTCTCTTGATGACCTTGGTTTAATTCCTACTTTAAGGCGTTATATAAATAAATTCAATGAACAGAC
TAAAATCATTATAGATTTTAATATTTTGGGTCCAAAAAGGCGGCTGCCAAATACATATGAAATTACAATATTTCGCTTAA
TTCAGGAAGGTCTTAATAACATTTATAAACACTCTAAAGCCAGTACAGGGACTGTTACCCTGGAATATACTCCTGAACAA
ATCAATATCTTAATCAGTGATGATGGTATCGGGTTTAAACCTGAAGAGGTGGGGGCCAATAAATTTGGCCTGGTAAGTAT
GAGAGAGAGGTGTGAGTTGTTAGGAGGTAAACTTGATCTTTTTTCTGAAAAAAACAAAGGGACAAAAATAAAAATAACAT
TACCAATAAAACAAAGAGGTGGGAAAGATGAAGCCGACAAAGGTATTAGTAGCTGA

Upstream 100 bases:

>100_bases
AGAATATTTAACTTTGTAGAAGTGGGGTTATTAATGAGTTTTGTGGATTTGTCAGGTCATAAATTATACAACCGGGAATT
GGGGATAGAGGGGGACACAG

Downstream 100 bases:

>100_bases
CGACCACGATCTGGTAAGAGAGGGGATCTGTAAACTCCTCGAATTATATGAAGATATTAAAGTAGTGGGAGAGGCTGGAG
ATGGCCTGGAAACCGTGAAA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MGQNIDPSRSLEKILEKTVEVLAESKKEIFTIAESIRREYDNIKRELDLINEEINEVVAKVDKLQEVNRIARIRLMEVSR
DFEKHSEYDIKYAYQQAEDTSVQIAVLREKEEQLKKRRAELENRLINLKRNIEKAENMVSRVGVVHDYLLGELSNLSEQF
DDLRQKQQLAIKIIQAQEDERKRVAREIHDGPAQSIANLVFRVELAQKLMDKDLKKARNELEDVKELVRLSMQEVRKIIY
DLRPMSLDDLGLIPTLRRYINKFNEQTKIIIDFNILGPKRRLPNTYEITIFRLIQEGLNNIYKHSKASTGTVTLEYTPEQ
INILISDDGIGFKPEEVGANKFGLVSMRERCELLGGKLDLFSEKNKGTKIKITLPIKQRGGKDEADKGISS

Sequences:

>Translated_391_residues
MGQNIDPSRSLEKILEKTVEVLAESKKEIFTIAESIRREYDNIKRELDLINEEINEVVAKVDKLQEVNRIARIRLMEVSR
DFEKHSEYDIKYAYQQAEDTSVQIAVLREKEEQLKKRRAELENRLINLKRNIEKAENMVSRVGVVHDYLLGELSNLSEQF
DDLRQKQQLAIKIIQAQEDERKRVAREIHDGPAQSIANLVFRVELAQKLMDKDLKKARNELEDVKELVRLSMQEVRKIIY
DLRPMSLDDLGLIPTLRRYINKFNEQTKIIIDFNILGPKRRLPNTYEITIFRLIQEGLNNIYKHSKASTGTVTLEYTPEQ
INILISDDGIGFKPEEVGANKFGLVSMRERCELLGGKLDLFSEKNKGTKIKITLPIKQRGGKDEADKGISS
>Mature_390_residues
GQNIDPSRSLEKILEKTVEVLAESKKEIFTIAESIRREYDNIKRELDLINEEINEVVAKVDKLQEVNRIARIRLMEVSRD
FEKHSEYDIKYAYQQAEDTSVQIAVLREKEEQLKKRRAELENRLINLKRNIEKAENMVSRVGVVHDYLLGELSNLSEQFD
DLRQKQQLAIKIIQAQEDERKRVAREIHDGPAQSIANLVFRVELAQKLMDKDLKKARNELEDVKELVRLSMQEVRKIIYD
LRPMSLDDLGLIPTLRRYINKFNEQTKIIIDFNILGPKRRLPNTYEITIFRLIQEGLNNIYKHSKASTGTVTLEYTPEQI
NILISDDGIGFKPEEVGANKFGLVSMRERCELLGGKLDLFSEKNKGTKIKITLPIKQRGGKDEADKGISS

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=196, Percent_Identity=26.0204081632653, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082311, Length=221, Percent_Identity=32.579185520362, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788812, Length=197, Percent_Identity=26.3959390862944, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45333; Mature: 45202

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQNIDPSRSLEKILEKTVEVLAESKKEIFTIAESIRREYDNIKRELDLINEEINEVVAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKLQEVNRIARIRLMEVSRDFEKHSEYDIKYAYQQAEDTSVQIAVLREKEEQLKKRRAE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
LENRLINLKRNIEKAENMVSRVGVVHDYLLGELSNLSEQFDDLRQKQQLAIKIIQAQEDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RKRVAREIHDGPAQSIANLVFRVELAQKLMDKDLKKARNELEDVKELVRLSMQEVRKIIY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRPMSLDDLGLIPTLRRYINKFNEQTKIIIDFNILGPKRRLPNTYEITIFRLIQEGLNN
HCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHH
IYKHSKASTGTVTLEYTPEQINILISDDGIGFKPEEVGANKFGLVSMRERCELLGGKLDL
HHHCCCCCCCEEEEEECCCEEEEEEECCCCCCCCHHCCCCCCCHHHHHHHHHHHCCCHHC
FSEKNKGTKIKITLPIKQRGGKDEADKGISS
CCCCCCCCEEEEEEEEHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GQNIDPSRSLEKILEKTVEVLAESKKEIFTIAESIRREYDNIKRELDLINEEINEVVAK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKLQEVNRIARIRLMEVSRDFEKHSEYDIKYAYQQAEDTSVQIAVLREKEEQLKKRRAE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
LENRLINLKRNIEKAENMVSRVGVVHDYLLGELSNLSEQFDDLRQKQQLAIKIIQAQEDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RKRVAREIHDGPAQSIANLVFRVELAQKLMDKDLKKARNELEDVKELVRLSMQEVRKIIY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRPMSLDDLGLIPTLRRYINKFNEQTKIIIDFNILGPKRRLPNTYEITIFRLIQEGLNN
HCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHH
IYKHSKASTGTVTLEYTPEQINILISDDGIGFKPEEVGANKFGLVSMRERCELLGGKLDL
HHHCCCCCCCEEEEEECCCEEEEEEECCCCCCCCHHCCCCCCCHHHHHHHHHHHCCCHHC
FSEKNKGTKIKITLPIKQRGGKDEADKGISS
CCCCCCCCEEEEEEEEHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]