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The map label for this gene is degU [H]

Identifier: 220933015

GI number: 220933015

Start: 2372799

End: 2373434

Strand: Reverse

Name: degU [H]

Synonym: Hore_21820

Alternate gene names: 220933015

Gene position: 2373434-2372799 (Counterclockwise)

Preceding gene: 220933016

Following gene: 220933013

Centisome position: 92.06

GC content: 40.72

Gene sequence:

>636_bases
ATGAAGCCGACAAAGGTATTAGTAGCTGACGACCACGATCTGGTAAGAGAGGGGATCTGTAAACTCCTCGAATTATATGA
AGATATTAAAGTAGTGGGAGAGGCTGGAGATGGCCTGGAAACCGTGAAAGGAGTCAGGGATCATTTTCCGGATCTGGTTT
TACTGGATTTAAATATGCCCCGGATGGGGGGAATAACAGCCATAAAGAAAATAAAGGAAATAAGCCCCGGGATAAAGGTA
TTAATACTGACCATCCATGATGAAGAAGAATATGTTTATGAGGTAATAAGGTCCGGGGCCGAGGGTTATATTCAAAAGGA
TGTCAAGCCTGAAGAATTAAAAAGAGCTATAGATAAGGTTATAAAAGGGGATAAAGTATTTCCCCGGTCAACAGAGAATG
AAGTGCGTGAGGTTGTTAATGAAAAATATGAAGTCTGTGAATTAAGCAGTAGAGAGCAGGAAGTACTGGAGCTTCTGGCC
CAGGGTATGAGCAACAAACAGATAGCCCAGGAACTGTTCATTAGTGAAAAAACTGTTAAGAATCATGTCAGCAATATTTT
AAGGAAGTTATCAGTTAATGACAGAACCCAGGCTGTTATAGTTGCTCTTAAAAGAGGTCTGGTATCACTGACCTAA

Upstream 100 bases:

>100_bases
AGGTGTGAGTTGTTAGGAGGTAAACTTGATCTTTTTTCTGAAAAAAACAAAGGGACAAAAATAAAAATAACATTACCAAT
AAAACAAAGAGGTGGGAAAG

Downstream 100 bases:

>100_bases
TTTATTGTCTATAATCTCCCAGAACCGGTCAGTACCATTTCCCAGCCGCCAGATGGCTATACCTTTCAGATTATATTTCT
TAACCAGCTCCAGTTTGAAG

Product: two component transcriptional regulator, LuxR family

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKPTKVLVADDHDLVREGICKLLELYEDIKVVGEAGDGLETVKGVRDHFPDLVLLDLNMPRMGGITAIKKIKEISPGIKV
LILTIHDEEEYVYEVIRSGAEGYIQKDVKPEELKRAIDKVIKGDKVFPRSTENEVREVVNEKYEVCELSSREQEVLELLA
QGMSNKQIAQELFISEKTVKNHVSNILRKLSVNDRTQAVIVALKRGLVSLT

Sequences:

>Translated_211_residues
MKPTKVLVADDHDLVREGICKLLELYEDIKVVGEAGDGLETVKGVRDHFPDLVLLDLNMPRMGGITAIKKIKEISPGIKV
LILTIHDEEEYVYEVIRSGAEGYIQKDVKPEELKRAIDKVIKGDKVFPRSTENEVREVVNEKYEVCELSSREQEVLELLA
QGMSNKQIAQELFISEKTVKNHVSNILRKLSVNDRTQAVIVALKRGLVSLT
>Mature_211_residues
MKPTKVLVADDHDLVREGICKLLELYEDIKVVGEAGDGLETVKGVRDHFPDLVLLDLNMPRMGGITAIKKIKEISPGIKV
LILTIHDEEEYVYEVIRSGAEGYIQKDVKPEELKRAIDKVIKGDKVFPRSTENEVREVVNEKYEVCELSSREQEVLELLA
QGMSNKQIAQELFISEKTVKNHVSNILRKLSVNDRTQAVIVALKRGLVSLT

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=41.747572815534, Blast_Score=145, Evalue=1e-36,
Organism=Escherichia coli, GI1788222, Length=208, Percent_Identity=33.6538461538462, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786747, Length=195, Percent_Identity=33.8461538461538, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1787473, Length=204, Percent_Identity=35.2941176470588, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790102, Length=189, Percent_Identity=32.8042328042328, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788546, Length=215, Percent_Identity=33.0232558139535, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788712, Length=185, Percent_Identity=27.027027027027, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789937, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787277, Length=132, Percent_Identity=34.0909090909091, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23776; Mature: 23776

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTKVLVADDHDLVREGICKLLELYEDIKVVGEAGDGLETVKGVRDHFPDLVLLDLNMP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCC
RMGGITAIKKIKEISPGIKVLILTIHDEEEYVYEVIRSGAEGYIQKDVKPEELKRAIDKV
CCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHH
IKGDKVFPRSTENEVREVVNEKYEVCELSSREQEVLELLAQGMSNKQIAQELFISEKTVK
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NHVSNILRKLSVNDRTQAVIVALKRGLVSLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPTKVLVADDHDLVREGICKLLELYEDIKVVGEAGDGLETVKGVRDHFPDLVLLDLNMP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCC
RMGGITAIKKIKEISPGIKVLILTIHDEEEYVYEVIRSGAEGYIQKDVKPEELKRAIDKV
CCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHH
IKGDKVFPRSTENEVREVVNEKYEVCELSSREQEVLELLAQGMSNKQIAQELFISEKTVK
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NHVSNILRKLSVNDRTQAVIVALKRGLVSLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]