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The map label for this gene is glmU [H]

Identifier: 220932956

GI number: 220932956

Start: 2313561

End: 2314931

Strand: Reverse

Name: glmU [H]

Synonym: Hore_21240

Alternate gene names: 220932956

Gene position: 2314931-2313561 (Counterclockwise)

Preceding gene: 220932957

Following gene: 220932955

Centisome position: 89.79

GC content: 42.16

Gene sequence:

>1371_bases
ATGGAATCTCAGGTATTAACTATAATTCTCGCCGCCGGCAAAGGAACAAGAATGAAATCCGGGCTGGCTAAAGTTTTGCA
TCCTGTTGCTGGAAAACCCATGATCAGCCACGTGATTAATAGTGCTTCTCCAATCAGCTCTTCTGTTGTGGTGATAGTGG
GGTACCAGGGTGATAAAGTAAAAGAGACCCTGGGTACAGGCTATACATACGTTCGCCAGGAAGAACAGCTGGGGACCGGC
CATGCGGTTTTACAGGCTAAAAAGTTAATCAAAAAACATCAGGGGCAGGTCCTGATTCTCTGTGGGGATACCCCGTTATT
AAGAGAAAAAACTTTAAGTGAACTGGTAGATGCCCAGAGAGAAACCGGGGCTGGAGTGGCTGTATTAACAGCCGATATAG
ATAACCCCCGGGGTTATGGGAGAATTATCAGGAATGAGGCCGGAAACCAGATAATAAAGATAGTTGAGGACTCTGATGCC
AGTGATGAAGAAAGACTGGTCAATGAAATTAACAGTGGAGTTTATTGTTTTGACAGCAACCAGCTCAGTGAGGCTCTGGA
AAACTTAACAAATGATAATGCCCAGGGTGAGTATTATCTTACTGATACTATTGCTTATTTGAGAAATAAAGGGGAGGTAG
TAGTCCCCGTTAAAGTTGATGATTCCCGGGAGATTATTGGCGTAAATGACCGGAGAAACCTGGCTAGGGCTGAGAGGGTT
TTAAGAAACAGGATTATAAATTATCACCTGGCCAATGGTGTCAGTATTATTGACCCTGACACCACTTATATTGATAGTAC
TGTTGAAATTGGACAGGATAGTGTTATTTATCCTTTTACTTATATAGAAGGAAGAACACGAATTGGCTCAGAAGTGGTTG
TCGGCCCCCATTCACATTTAATAAATGCTGAAATTGGAGATAGAAGTAAACTCCTCGATTCTACTGTTATTAAAGATAGC
AAAATAGGGGAAGATACCAATATTGGTCCCTTTGCCTATATAAGGCCTGGCTGTCAGATTGCCAGTGGGGTTAAGGTTGG
GGATTTTGTTGAATTAAAAAAAGCAAAGATCGGGGAAAATACCAAAGTTCCTCATTTGAGTTATGTAGGGGATGCTGAAA
TAGGGGAAAATAGTAATATTGGAGCCGGTACAATATTTGCAAATTATGATGGGAAGAAAAAGCATAAAACAAAAGTGGGT
AATAATGCCTTCATCGGGAGTAATACAACCTTGATTGCTCCAGTAACGGTTGGAAACAGGGGAAAAACAGGGGCCGGTGC
TGTTGTGACTAAAGATGTCCCCGGAGGGGTAACAGTGGTCGGTGTACCTGCTCGTAAATTTAAAAAGGATAACATTGAGG
GGGATAAATAA

Upstream 100 bases:

>100_bases
ATTGGCCTTAAAATACAACACCTTATTAAGGAAAAGAACAGGGAAATTATTAATAATGATTCTTTTACAATTAATCTGGA
AAAGGTAGGGGGCTGAATTG

Downstream 100 bases:

>100_bases
TGTCTACTTATGGAGATAAGTTGAAGATTTTTACCGGCAATGCTCACCGCAAATTGGCTGAAGATATCTGTGAATGTCTG
GGTACCGAACTTGTTAGTTC

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MESQVLTIILAAGKGTRMKSGLAKVLHPVAGKPMISHVINSASPISSSVVVIVGYQGDKVKETLGTGYTYVRQEEQLGTG
HAVLQAKKLIKKHQGQVLILCGDTPLLREKTLSELVDAQRETGAGVAVLTADIDNPRGYGRIIRNEAGNQIIKIVEDSDA
SDEERLVNEINSGVYCFDSNQLSEALENLTNDNAQGEYYLTDTIAYLRNKGEVVVPVKVDDSREIIGVNDRRNLARAERV
LRNRIINYHLANGVSIIDPDTTYIDSTVEIGQDSVIYPFTYIEGRTRIGSEVVVGPHSHLINAEIGDRSKLLDSTVIKDS
KIGEDTNIGPFAYIRPGCQIASGVKVGDFVELKKAKIGENTKVPHLSYVGDAEIGENSNIGAGTIFANYDGKKKHKTKVG
NNAFIGSNTTLIAPVTVGNRGKTGAGAVVTKDVPGGVTVVGVPARKFKKDNIEGDK

Sequences:

>Translated_456_residues
MESQVLTIILAAGKGTRMKSGLAKVLHPVAGKPMISHVINSASPISSSVVVIVGYQGDKVKETLGTGYTYVRQEEQLGTG
HAVLQAKKLIKKHQGQVLILCGDTPLLREKTLSELVDAQRETGAGVAVLTADIDNPRGYGRIIRNEAGNQIIKIVEDSDA
SDEERLVNEINSGVYCFDSNQLSEALENLTNDNAQGEYYLTDTIAYLRNKGEVVVPVKVDDSREIIGVNDRRNLARAERV
LRNRIINYHLANGVSIIDPDTTYIDSTVEIGQDSVIYPFTYIEGRTRIGSEVVVGPHSHLINAEIGDRSKLLDSTVIKDS
KIGEDTNIGPFAYIRPGCQIASGVKVGDFVELKKAKIGENTKVPHLSYVGDAEIGENSNIGAGTIFANYDGKKKHKTKVG
NNAFIGSNTTLIAPVTVGNRGKTGAGAVVTKDVPGGVTVVGVPARKFKKDNIEGDK
>Mature_456_residues
MESQVLTIILAAGKGTRMKSGLAKVLHPVAGKPMISHVINSASPISSSVVVIVGYQGDKVKETLGTGYTYVRQEEQLGTG
HAVLQAKKLIKKHQGQVLILCGDTPLLREKTLSELVDAQRETGAGVAVLTADIDNPRGYGRIIRNEAGNQIIKIVEDSDA
SDEERLVNEINSGVYCFDSNQLSEALENLTNDNAQGEYYLTDTIAYLRNKGEVVVPVKVDDSREIIGVNDRRNLARAERV
LRNRIINYHLANGVSIIDPDTTYIDSTVEIGQDSVIYPFTYIEGRTRIGSEVVVGPHSHLINAEIGDRSKLLDSTVIKDS
KIGEDTNIGPFAYIRPGCQIASGVKVGDFVELKKAKIGENTKVPHLSYVGDAEIGENSNIGAGTIFANYDGKKKHKTKVG
NNAFIGSNTTLIAPVTVGNRGKTGAGAVVTKDVPGGVTVVGVPARKFKKDNIEGDK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=428, Percent_Identity=43.6915887850467, Blast_Score=334, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI133931050, Length=385, Percent_Identity=23.1168831168831, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=383, Percent_Identity=25.3263707571802, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49059; Mature: 49059

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESQVLTIILAAGKGTRMKSGLAKVLHPVAGKPMISHVINSASPISSSVVVIVGYQGDKV
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEECCCCHH
KETLGTGYTYVRQEEQLGTGHAVLQAKKLIKKHQGQVLILCGDTPLLREKTLSELVDAQR
HHHHCCCEEEEECHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
ETGAGVAVLTADIDNPRGYGRIIRNEAGNQIIKIVEDSDASDEERLVNEINSGVYCFDSN
HCCCCEEEEEEECCCCCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEECCH
QLSEALENLTNDNAQGEYYLTDTIAYLRNKGEVVVPVKVDDSREIIGVNDRRNLARAERV
HHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCEEECCCCHHHHHHHHH
LRNRIINYHLANGVSIIDPDTTYIDSTVEIGQDSVIYPFTYIEGRTRIGSEVVVGPHSHL
HHHHHHEEEECCCCEEECCCCCEECCCCCCCCCCEEEEEEEECCCCCCCCEEEECCCCEE
INAEIGDRSKLLDSTVIKDSKIGEDTNIGPFAYIRPGCQIASGVKVGDFVELKKAKIGEN
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHHHHHHCCCC
TKVPHLSYVGDAEIGENSNIGAGTIFANYDGKKKHKTKVGNNAFIGSNTTLIAPVTVGNR
CCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCEEECCCCEEEEEEEECCC
GKTGAGAVVTKDVPGGVTVVGVPARKFKKDNIEGDK
CCCCCCEEEEECCCCCEEEEECCHHHHHCCCCCCCC
>Mature Secondary Structure
MESQVLTIILAAGKGTRMKSGLAKVLHPVAGKPMISHVINSASPISSSVVVIVGYQGDKV
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEECCCCHH
KETLGTGYTYVRQEEQLGTGHAVLQAKKLIKKHQGQVLILCGDTPLLREKTLSELVDAQR
HHHHCCCEEEEECHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
ETGAGVAVLTADIDNPRGYGRIIRNEAGNQIIKIVEDSDASDEERLVNEINSGVYCFDSN
HCCCCEEEEEEECCCCCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEECCH
QLSEALENLTNDNAQGEYYLTDTIAYLRNKGEVVVPVKVDDSREIIGVNDRRNLARAERV
HHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCEEECCCCHHHHHHHHH
LRNRIINYHLANGVSIIDPDTTYIDSTVEIGQDSVIYPFTYIEGRTRIGSEVVVGPHSHL
HHHHHHEEEECCCCEEECCCCCEECCCCCCCCCCEEEEEEEECCCCCCCCEEEECCCCEE
INAEIGDRSKLLDSTVIKDSKIGEDTNIGPFAYIRPGCQIASGVKVGDFVELKKAKIGEN
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHHHHHHCCCC
TKVPHLSYVGDAEIGENSNIGAGTIFANYDGKKKHKTKVGNNAFIGSNTTLIAPVTVGNR
CCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCEEECCCCEEEEEEEECCC
GKTGAGAVVTKDVPGGVTVVGVPARKFKKDNIEGDK
CCCCCCEEEEECCCCCEEEEECCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA