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The map label for this gene is prs [H]

Identifier: 220932955

GI number: 220932955

Start: 2312617

End: 2313561

Strand: Reverse

Name: prs [H]

Synonym: Hore_21230

Alternate gene names: 220932955

Gene position: 2313561-2312617 (Counterclockwise)

Preceding gene: 220932956

Following gene: 220932954

Centisome position: 89.74

GC content: 42.54

Gene sequence:

>945_bases
ATGTCTACTTATGGAGATAAGTTGAAGATTTTTACCGGCAATGCTCACCGCAAATTGGCTGAAGATATCTGTGAATGTCT
GGGTACCGAACTTGTTAGTTCAGAGGTCAATAGGTTTAAAGATGGTGAAATATCAGTAAAAATTGAGGAAACAGTCCGTG
GGGCAGATGTTTTTGTTATTCAACCTACCTGTCCTCCTGTTAATGAGAATTTGATGGAATTACTGGTAATGGTAGATGCT
TTAAGAAGGGCTTCAGCCCGGAGAATTACTGCTGTTGTTCCGTATTATGGTTATGCCAGACAGGACCGGAAAGCCCGTCC
CCGTGATCCCATTACGGCTAAACTGGTAGCAAATCTGATTACTACAGCTGGAGCCAGAAGGCTGCTTTCTATAGATATGC
ATGCCCCCCAGATTCAGGGTTTTTTTGATATTCCTGTTGACCACCTTTATGCTGCCCCGATTATGGTTGACTATTTTAAA
AAGAAAAATATAGAGAATATGACTGCTGTTGCTCCAGATGTCGGTGCTGTTAAAAGGGTTCGTTCTTTTGCCCAGGCCCT
TAATATTCCCATGGCCATTATTGATAAAAGAAGACCAAAGCCCAATGTGGCCGAAGTCCAGCATGTTATCGGGGATGTAG
AAGGAAGAAATGTTATTCTCTTTGATGATATTATCGATACCGCCGGTACAATCGTTGAGGCTGCCCGGGTTTTAAAAGAA
AAAGGAGCTGCCAATGTCTTTGCCTGCTGTACTCATGCCCTGTTTTCTGGGCCGGCTGAAGAGAGGCTGAAAAATGCTCC
ATTAAAGGAGATTATAGTTACTGATACCATCCCCCAGAAGGATAACAGTCTCGATAACTTAAAAATATTATCAGTGGCTC
CGCTCCTGGCTGAAGCCATTGACCGAATCTATAAAGACCTGTCTGTATCAGTTTTATTTCATTAA

Upstream 100 bases:

>100_bases
GGGCCGGTGCTGTTGTGACTAAAGATGTCCCCGGAGGGGTAACAGTGGTCGGTGTACCTGCTCGTAAATTTAAAAAGGAT
AACATTGAGGGGGATAAATA

Downstream 100 bases:

>100_bases
TATGGTACTTGTTTAACTTCAAACAGGATGTTATAATATTTTTCAGTAAAAAATCTGACTGACACTCAATATAAAATTGA
AAAGGAGAGGATAGTCAAAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSTYGDKLKIFTGNAHRKLAEDICECLGTELVSSEVNRFKDGEISVKIEETVRGADVFVIQPTCPPVNENLMELLVMVDA
LRRASARRITAVVPYYGYARQDRKARPRDPITAKLVANLITTAGARRLLSIDMHAPQIQGFFDIPVDHLYAAPIMVDYFK
KKNIENMTAVAPDVGAVKRVRSFAQALNIPMAIIDKRRPKPNVAEVQHVIGDVEGRNVILFDDIIDTAGTIVEAARVLKE
KGAANVFACCTHALFSGPAEERLKNAPLKEIIVTDTIPQKDNSLDNLKILSVAPLLAEAIDRIYKDLSVSVLFH

Sequences:

>Translated_314_residues
MSTYGDKLKIFTGNAHRKLAEDICECLGTELVSSEVNRFKDGEISVKIEETVRGADVFVIQPTCPPVNENLMELLVMVDA
LRRASARRITAVVPYYGYARQDRKARPRDPITAKLVANLITTAGARRLLSIDMHAPQIQGFFDIPVDHLYAAPIMVDYFK
KKNIENMTAVAPDVGAVKRVRSFAQALNIPMAIIDKRRPKPNVAEVQHVIGDVEGRNVILFDDIIDTAGTIVEAARVLKE
KGAANVFACCTHALFSGPAEERLKNAPLKEIIVTDTIPQKDNSLDNLKILSVAPLLAEAIDRIYKDLSVSVLFH
>Mature_313_residues
STYGDKLKIFTGNAHRKLAEDICECLGTELVSSEVNRFKDGEISVKIEETVRGADVFVIQPTCPPVNENLMELLVMVDAL
RRASARRITAVVPYYGYARQDRKARPRDPITAKLVANLITTAGARRLLSIDMHAPQIQGFFDIPVDHLYAAPIMVDYFKK
KNIENMTAVAPDVGAVKRVRSFAQALNIPMAIIDKRRPKPNVAEVQHVIGDVEGRNVILFDDIIDTAGTIVEAARVLKEK
GAANVFACCTHALFSGPAEERLKNAPLKEIIVTDTIPQKDNSLDNLKILSVAPLLAEAIDRIYKDLSVSVLFH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=46.4516129032258, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=45.7792207792208, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=45.3376205787781, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=44.8387096774194, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4506133, Length=351, Percent_Identity=35.3276353276353, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=35.672514619883, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=29.8611111111111, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=29.8611111111111, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=29.8611111111111, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=29.8611111111111, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=53.6977491961415, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=45.1612903225806, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=45.1612903225806, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=45.1298701298701, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=45.1612903225806, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=35.2238805970149, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=44.620253164557, Blast_Score=262, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=44.2307692307692, Blast_Score=258, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=41.6666666666667, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=42.9292929292929, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324511, Length=105, Percent_Identity=40.9523809523809, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=46.1290322580645, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=43.2432432432432, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24651458, Length=359, Percent_Identity=33.4261838440111, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651456, Length=359, Percent_Identity=33.4261838440111, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281362873, Length=359, Percent_Identity=33.4261838440111, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651454, Length=359, Percent_Identity=33.4261838440111, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651462, Length=207, Percent_Identity=35.2657004830918, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24651464, Length=207, Percent_Identity=35.2657004830918, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45552010, Length=207, Percent_Identity=35.2657004830918, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34701; Mature: 34570

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYGDKLKIFTGNAHRKLAEDICECLGTELVSSEVNRFKDGEISVKIEETVRGADVFVI
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCEEEEE
QPTCPPVNENLMELLVMVDALRRASARRITAVVPYYGYARQDRKARPRDPITAKLVANLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
TTAGARRLLSIDMHAPQIQGFFDIPVDHLYAAPIMVDYFKKKNIENMTAVAPDVGAVKRV
HHHHHHHEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHH
RSFAQALNIPMAIIDKRRPKPNVAEVQHVIGDVEGRNVILFDDIIDTAGTIVEAARVLKE
HHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
KGAANVFACCTHALFSGPAEERLKNAPLKEIIVTDTIPQKDNSLDNLKILSVAPLLAEAI
CCCCHHHHHHHHHHHCCCHHHHHHCCCHHHEEEECCCCCCCCCCCCEEHHHHHHHHHHHH
DRIYKDLSVSVLFH
HHHHHCCCEEEEEC
>Mature Secondary Structure 
STYGDKLKIFTGNAHRKLAEDICECLGTELVSSEVNRFKDGEISVKIEETVRGADVFVI
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCEEEEE
QPTCPPVNENLMELLVMVDALRRASARRITAVVPYYGYARQDRKARPRDPITAKLVANLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
TTAGARRLLSIDMHAPQIQGFFDIPVDHLYAAPIMVDYFKKKNIENMTAVAPDVGAVKRV
HHHHHHHEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHH
RSFAQALNIPMAIIDKRRPKPNVAEVQHVIGDVEGRNVILFDDIIDTAGTIVEAARVLKE
HHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
KGAANVFACCTHALFSGPAEERLKNAPLKEIIVTDTIPQKDNSLDNLKILSVAPLLAEAI
CCCCHHHHHHHHHHHCCCHHHHHHCCCHHHEEEECCCCCCCCCCCCEEHHHHHHHHHHHH
DRIYKDLSVSVLFH
HHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]