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The map label for this gene is tadA [H]

Identifier: 220932912

GI number: 220932912

Start: 2248850

End: 2249329

Strand: Reverse

Name: tadA [H]

Synonym: Hore_20800

Alternate gene names: 220932912

Gene position: 2249329-2248850 (Counterclockwise)

Preceding gene: 220932914

Following gene: 220932911

Centisome position: 87.25

GC content: 45.21

Gene sequence:

>480_bases
ATGAAGACAGATGAAGACTTTATGGAGCTTGCCCTTGAAGAAGCCAGAAAAGCATTAGCCCTTGAAGAAGTACCCATCGG
GGCAGTAGTCGTTTGTAATGGAGAAATTGTGGGGAGTGGTCATAATTTAAAGGAAACTGAAAATGACCCCACTGCCCATG
CTGAGATTGTTGCTATCAGAGATGCAGCTAGAAAACTTTCGAGCTGGCGTTTAAATGAATGTCAGCTTTATGTAACTATA
GAACCATGCCCCATGTGTGCCGGGGCAATTATGCAGGCACGCCTTCAAAGGGTTGTCTATGGAGCGGTTGATCCTAAAGC
TGGTGTAGCAGGTTCTTTATATAACCTGTTACAGGATAACCGTTTTAACCATACAGTAGAGCTTAAAAGTGGTGTGCTGG
CTGCTGAATGCCGGCAAATTATTAAGGATTTTTTCAGCGAATTGAGGCAAACCCGGGGAAGGGTGGGTGAGTCTGGCTGA

Upstream 100 bases:

>100_bases
GTCTGACTACGGATCAGAAGGTTGAGGGTTCGAGTCCTTCCGGGCACGCCATTCCTTTGATTTAAGGAGGATAGGGGCTT
TTTATAAAGCCTTTATATAG

Downstream 100 bases:

>100_bases
AACCGCTCGACTCGAAATCGAGTAGGCACATTAAGTGTCTCGAGGGTTCAAATCCCTCCCCTTCCGCCAGGAATATAAAT
AGAGCTTATAAGCGTGGAGA

Product: tRNA-adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKTDEDFMELALEEARKALALEEVPIGAVVVCNGEIVGSGHNLKETENDPTAHAEIVAIRDAARKLSSWRLNECQLYVTI
EPCPMCAGAIMQARLQRVVYGAVDPKAGVAGSLYNLLQDNRFNHTVELKSGVLAAECRQIIKDFFSELRQTRGRVGESG

Sequences:

>Translated_159_residues
MKTDEDFMELALEEARKALALEEVPIGAVVVCNGEIVGSGHNLKETENDPTAHAEIVAIRDAARKLSSWRLNECQLYVTI
EPCPMCAGAIMQARLQRVVYGAVDPKAGVAGSLYNLLQDNRFNHTVELKSGVLAAECRQIIKDFFSELRQTRGRVGESG
>Mature_159_residues
MKTDEDFMELALEEARKALALEEVPIGAVVVCNGEIVGSGHNLKETENDPTAHAEIVAIRDAARKLSSWRLNECQLYVTI
EPCPMCAGAIMQARLQRVVYGAVDPKAGVAGSLYNLLQDNRFNHTVELKSGVLAAECRQIIKDFFSELRQTRGRVGESG

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=151, Percent_Identity=35.7615894039735, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI145693172, Length=148, Percent_Identity=46.6216216216216, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786616, Length=155, Percent_Identity=33.5483870967742, Blast_Score=66, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17554608, Length=107, Percent_Identity=43.9252336448598, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17541138, Length=148, Percent_Identity=34.4594594594595, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17555996, Length=102, Percent_Identity=39.2156862745098, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325319, Length=154, Percent_Identity=35.0649350649351, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355527, Length=147, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 17445; Mature: 17445

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDEDFMELALEEARKALALEEVPIGAVVVCNGEIVGSGHNLKETENDPTAHAEIVAIR
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHH
DAARKLSSWRLNECQLYVTIEPCPMCAGAIMQARLQRVVYGAVDPKAGVAGSLYNLLQDN
HHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
RFNHTVELKSGVLAAECRQIIKDFFSELRQTRGRVGESG
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTDEDFMELALEEARKALALEEVPIGAVVVCNGEIVGSGHNLKETENDPTAHAEIVAIR
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHH
DAARKLSSWRLNECQLYVTIEPCPMCAGAIMQARLQRVVYGAVDPKAGVAGSLYNLLQDN
HHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
RFNHTVELKSGVLAAECRQIIKDFFSELRQTRGRVGESG
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1698458; 7584024; 9384377 [H]