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The map label for this gene is lacZ [H]

Identifier: 220932891

GI number: 220932891

Start: 2225388

End: 2228066

Strand: Reverse

Name: lacZ [H]

Synonym: Hore_20590

Alternate gene names: 220932891

Gene position: 2228066-2225388 (Counterclockwise)

Preceding gene: 220932892

Following gene: 220932890

Centisome position: 86.42

GC content: 35.76

Gene sequence:

>2679_bases
ATGGGATGTATTATTAAAGAATTAAATGGACTATGGAACTTTACGACAGACCCAGAAAAAATTGGAGAACAGAATGAATG
GTATATTAACGGTTTTGAAGGTGAGTCCGTTAAGGTCCCCGGGGCCTGGCAAACTTACAATAAAGAGATGGTTACTTATA
CAGGCTATGCCTGGTACTCAAGGGAGTTTAATATAAATGAAGCCATCCACGAATTTAAGAGATTTTTCTTAAAGTTTGAA
GCGGTAGATTATGTGTCTGATGTATGGATAAATGGTAAATACCTGGGTTCCCACGAGGGAGGGTATACCCCTTTCGATTT
TGAAGTTACCGAGCACCTTAAAGAAGGGGATAATTTAATTGTGGTCAGGGTTTTTGATCCTGATGATAATGATGAGATTC
CCCATGGCAAACAGGGAAGCTGGTATACAAGGGTAAGTGGTATCTGGCAGGATGTATTATTAGTTGGATATGACAAAACC
TTTATTGAAAATGTTCTTATCACCCCTGATATTGATAATAAACGGGCTATAACCCAAGTTAAAATAAAAGATAGAGATAG
GCTAGTCAACCCCAGAATAGAATTTAAAATAGACCCCAGGGTAAATGGTAATAAAGTAGAGGGAAGTAAAACACATACTT
ATAAGTATTTCCTGGATGAACAGGAGTTATATGAACTGGAAATTTTAGATTTATATTTATGGGGTCCAGAATCACCGGCC
TTATACGACATGACAGTTATATTAAAGGATGGCAATAGTATAATTGACAGTTATCAAACTTACTTTGGAATGAGGAAAAT
AGAATATAAAAATGGGATGGTATATTTAAATCATAAACCATTATATATAAGAGGGGCCCTGGACCAGGCCTTCTGGCCTA
AAACCATCTACCGACCGGAAAGTGAAGAGTTGATAAAAGAGGAGATATTAAAGGCTAAAGAGATGGGTTTTAACCTTTTA
AGAAAACATATAAAGACAGAAGACCCCAGATATCTTTACTGGGCCGATTATCTTGGAATGTTAATTTGGGAAGAACCGGC
TAACTATGCCAGCTGGACCCCGCAGGCAAGGAAGAGGTTTAAAAAGGAATTTACCAGAATGGTTAAAAGAGACTATAACC
ATCCTTCAATTATTGCCTGGAGTATATACAATGAAGAGTGGGGACTGGAATGGAAACTAAAAGAAAATAAGGATATGCAA
AAGTGGGTTGAAGGTTTTTATGAATATGCCAGGGAGCTGGATCCTACCCGGTTAATCTGTGACAATTCAGGATGGGCCCA
TGTCAAAACAGATATAAATGATTACCACCGATATTTTGCTGTACCGGAAAATCATAAAGAATGGCAGGAAGATCTGGATA
ATTATATTATAAAAAAACCTGGAGCAAATTATGTTGACGGGTATAAATATAACGGAGAACCTTTAATTGTTTCCGAGTTT
GGTATGTGGGGCTTACCGGAAATAAGTAAAATCGAAGAGGCATATGAGGAGTTGCCTGAATGGTACCGGGGTAATTCAAA
ATTATTTTCGGAGGACTTTAAAATACCTGCTACCCTGAAAGAAAATTATAAAAAATATAATCTTAATAAAATATTCAAAA
GTTATGATGAGCTATGTTATTTAACCCAGGAGAGGCAATTTAGAGGGGTAAAGAGTATTATAGAGGAGATGAGAAAAAGA
AGTGAGATTGCAGGATATGTAGTAACAGAACTGACAGATATTGAATGGGAAACTAACGGATTTCTGGATTACTTTAGAAA
TCCTAAATTTAGAAATAATTGTATTAACCATTTTAATGGCCAGGTGATTCTTGCTATTAATATAAATAAACATAACTTCT
GGTCAGGTGAAGAATGCTCCTTTACTCCCATAGTTATAAACAATAGTGATAAAAAGATTCAGGGAGTTTTTAGATGGTAT
TTGGAAGAAAGCGAATTGAAGGGGATCTTTCCTGTTAAGATACCGGCTTATTCAAACCAGCGTCTTGATGAAATTAAATT
TAACTTCCCTGGTGACTGGACAGGATCCAGAGGGGTTAAATTGAGGGTTGAGCTGGAAGAGGAAAAAGAGGTAGTTACTT
CAAATTATGAAGAATTAACGGTAACCAATCGAAGAGAAATAAAGAAAACAGGGAAGTCATTACAGGTAAAGGGTTTATCT
CATGAATTTAAAAATAAACTTAAGAACAATGGATTTGAATTGAAAACTAATAATTCCCTTGTACTTACTGATAATTTGAC
TGAAGAAGTACTAAAAGAAGTGCGTAATGGGACCCGGGTAGTTTTTCTGGCTGAAAATGGCAACAGGATTCAGGATAAGG
GTTATATTAATTTTACCAAATTGCCTGGTGGCGAGAGCTGGGATAGGGCTGCTACCTTTAATTTCATAAATACAGATATT
TTTGATGGTATTCCCCTTTTAAAAATTTCGGGTTGGGAACTTGAAGATATCTATCCAGATTACAAGGTCAAAAACCTGGT
TGATTTAAATTGTACAGAAATAATAAGTGGTAATTTTGCCGGATGGTTAGGTGACTTTGGGGCAACTACCTTTGTTATGA
ACTGGGGCAGGGGTCAGGTATTAGTTACAACATTAAAATTAATTTCTAATTATCATACTCACCCTATTGCCAGTCTTTTA
TTAAATAAACTTATAAATTATTTTCAAGAACACAAATAA

Upstream 100 bases:

>100_bases
GAAGTGTTTAAACAAATTGCTAAAGGAGATAAACAGGAGATTGTTGGAGATATTGCTTTGAAAAAATAGTTCAAGTTAAT
AGCAGGGGGGTAAAGTGCTG

Downstream 100 bases:

>100_bases
AAAAAGCTGAAAGTTTTTAAGCAATAGGGAACCACCAATTATTTTTGTAAACCTGATGCAAGTACTTTAGTTATGGATAT
AAAGCATATAAAAAGGAGAG

Product: glycoside hydrolase family 2 sugar binding

Products: NA

Alternate protein names: Beta-gal; Lactase [H]

Number of amino acids: Translated: 892; Mature: 891

Protein sequence:

>892_residues
MGCIIKELNGLWNFTTDPEKIGEQNEWYINGFEGESVKVPGAWQTYNKEMVTYTGYAWYSREFNINEAIHEFKRFFLKFE
AVDYVSDVWINGKYLGSHEGGYTPFDFEVTEHLKEGDNLIVVRVFDPDDNDEIPHGKQGSWYTRVSGIWQDVLLVGYDKT
FIENVLITPDIDNKRAITQVKIKDRDRLVNPRIEFKIDPRVNGNKVEGSKTHTYKYFLDEQELYELEILDLYLWGPESPA
LYDMTVILKDGNSIIDSYQTYFGMRKIEYKNGMVYLNHKPLYIRGALDQAFWPKTIYRPESEELIKEEILKAKEMGFNLL
RKHIKTEDPRYLYWADYLGMLIWEEPANYASWTPQARKRFKKEFTRMVKRDYNHPSIIAWSIYNEEWGLEWKLKENKDMQ
KWVEGFYEYARELDPTRLICDNSGWAHVKTDINDYHRYFAVPENHKEWQEDLDNYIIKKPGANYVDGYKYNGEPLIVSEF
GMWGLPEISKIEEAYEELPEWYRGNSKLFSEDFKIPATLKENYKKYNLNKIFKSYDELCYLTQERQFRGVKSIIEEMRKR
SEIAGYVVTELTDIEWETNGFLDYFRNPKFRNNCINHFNGQVILAININKHNFWSGEECSFTPIVINNSDKKIQGVFRWY
LEESELKGIFPVKIPAYSNQRLDEIKFNFPGDWTGSRGVKLRVELEEEKEVVTSNYEELTVTNRREIKKTGKSLQVKGLS
HEFKNKLKNNGFELKTNNSLVLTDNLTEEVLKEVRNGTRVVFLAENGNRIQDKGYINFTKLPGGESWDRAATFNFINTDI
FDGIPLLKISGWELEDIYPDYKVKNLVDLNCTEIISGNFAGWLGDFGATTFVMNWGRGQVLVTTLKLISNYHTHPIASLL
LNKLINYFQEHK

Sequences:

>Translated_892_residues
MGCIIKELNGLWNFTTDPEKIGEQNEWYINGFEGESVKVPGAWQTYNKEMVTYTGYAWYSREFNINEAIHEFKRFFLKFE
AVDYVSDVWINGKYLGSHEGGYTPFDFEVTEHLKEGDNLIVVRVFDPDDNDEIPHGKQGSWYTRVSGIWQDVLLVGYDKT
FIENVLITPDIDNKRAITQVKIKDRDRLVNPRIEFKIDPRVNGNKVEGSKTHTYKYFLDEQELYELEILDLYLWGPESPA
LYDMTVILKDGNSIIDSYQTYFGMRKIEYKNGMVYLNHKPLYIRGALDQAFWPKTIYRPESEELIKEEILKAKEMGFNLL
RKHIKTEDPRYLYWADYLGMLIWEEPANYASWTPQARKRFKKEFTRMVKRDYNHPSIIAWSIYNEEWGLEWKLKENKDMQ
KWVEGFYEYARELDPTRLICDNSGWAHVKTDINDYHRYFAVPENHKEWQEDLDNYIIKKPGANYVDGYKYNGEPLIVSEF
GMWGLPEISKIEEAYEELPEWYRGNSKLFSEDFKIPATLKENYKKYNLNKIFKSYDELCYLTQERQFRGVKSIIEEMRKR
SEIAGYVVTELTDIEWETNGFLDYFRNPKFRNNCINHFNGQVILAININKHNFWSGEECSFTPIVINNSDKKIQGVFRWY
LEESELKGIFPVKIPAYSNQRLDEIKFNFPGDWTGSRGVKLRVELEEEKEVVTSNYEELTVTNRREIKKTGKSLQVKGLS
HEFKNKLKNNGFELKTNNSLVLTDNLTEEVLKEVRNGTRVVFLAENGNRIQDKGYINFTKLPGGESWDRAATFNFINTDI
FDGIPLLKISGWELEDIYPDYKVKNLVDLNCTEIISGNFAGWLGDFGATTFVMNWGRGQVLVTTLKLISNYHTHPIASLL
LNKLINYFQEHK
>Mature_891_residues
GCIIKELNGLWNFTTDPEKIGEQNEWYINGFEGESVKVPGAWQTYNKEMVTYTGYAWYSREFNINEAIHEFKRFFLKFEA
VDYVSDVWINGKYLGSHEGGYTPFDFEVTEHLKEGDNLIVVRVFDPDDNDEIPHGKQGSWYTRVSGIWQDVLLVGYDKTF
IENVLITPDIDNKRAITQVKIKDRDRLVNPRIEFKIDPRVNGNKVEGSKTHTYKYFLDEQELYELEILDLYLWGPESPAL
YDMTVILKDGNSIIDSYQTYFGMRKIEYKNGMVYLNHKPLYIRGALDQAFWPKTIYRPESEELIKEEILKAKEMGFNLLR
KHIKTEDPRYLYWADYLGMLIWEEPANYASWTPQARKRFKKEFTRMVKRDYNHPSIIAWSIYNEEWGLEWKLKENKDMQK
WVEGFYEYARELDPTRLICDNSGWAHVKTDINDYHRYFAVPENHKEWQEDLDNYIIKKPGANYVDGYKYNGEPLIVSEFG
MWGLPEISKIEEAYEELPEWYRGNSKLFSEDFKIPATLKENYKKYNLNKIFKSYDELCYLTQERQFRGVKSIIEEMRKRS
EIAGYVVTELTDIEWETNGFLDYFRNPKFRNNCINHFNGQVILAININKHNFWSGEECSFTPIVINNSDKKIQGVFRWYL
EESELKGIFPVKIPAYSNQRLDEIKFNFPGDWTGSRGVKLRVELEEEKEVVTSNYEELTVTNRREIKKTGKSLQVKGLSH
EFKNKLKNNGFELKTNNSLVLTDNLTEEVLKEVRNGTRVVFLAENGNRIQDKGYINFTKLPGGESWDRAATFNFINTDIF
DGIPLLKISGWELEDIYPDYKVKNLVDLNCTEIISGNFAGWLGDFGATTFVMNWGRGQVLVTTLKLISNYHTHPIASLLL
NKLINYFQEHK

Specific function: Unknown

COG id: COG3250

COG function: function code G; Beta-galactosidase/beta-glucuronidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI268834192, Length=544, Percent_Identity=22.2426470588235, Blast_Score=91, Evalue=5e-18,
Organism=Escherichia coli, GI1787903, Length=481, Percent_Identity=25.5717255717256, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786539, Length=465, Percent_Identity=24.9462365591398, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI48994920, Length=454, Percent_Identity=23.7885462555066, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17510825, Length=610, Percent_Identity=23.4426229508197, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922582, Length=554, Percent_Identity=23.826714801444, Blast_Score=110, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24655438, Length=554, Percent_Identity=23.826714801444, Blast_Score=110, Evalue=6e-24,
Organism=Drosophila melanogaster, GI62471735, Length=554, Percent_Identity=23.826714801444, Blast_Score=109, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24651745, Length=590, Percent_Identity=24.0677966101695, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003344
- InterPro:   IPR008979
- InterPro:   IPR006101
- InterPro:   IPR013812
- InterPro:   IPR006104
- InterPro:   IPR006102
- InterPro:   IPR006103
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00703 Glyco_hydro_2; PF02836 Glyco_hydro_2_C; PF02837 Glyco_hydro_2_N [H]

EC number: =3.2.1.23 [H]

Molecular weight: Translated: 105052; Mature: 104921

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCIIKELNGLWNFTTDPEKIGEQNEWYINGFEGESVKVPGAWQTYNKEMVTYTGYAWYS
CCCHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCEEECCCCHHCCCCCEEEEEEEEEEE
REFNINEAIHEFKRFFLKFEAVDYVSDVWINGKYLGSHEGGYTPFDFEVTEHLKEGDNLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCEEECCCCCCCCCCCHHHHHHHHCCCCEE
VVRVFDPDDNDEIPHGKQGSWYTRVSGIWQDVLLVGYDKTFIENVLITPDIDNKRAITQV
EEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHEECCCHHHHCCEEECCCCCCCCEEEEE
KIKDRDRLVNPRIEFKIDPRVNGNKVEGSKTHTYKYFLDEQELYELEILDLYLWGPESPA
EECCCCCCCCCEEEEEECCCCCCCEECCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCC
LYDMTVILKDGNSIIDSYQTYFGMRKIEYKNGMVYLNHKPLYIRGALDQAFWPKTIYRPE
EEEEEEEEECCCHHHHHHHHHHCCEEEEECCCEEEECCCCEEEEECCCCCCCCCCCCCCC
SEELIKEEILKAKEMGFNLLRKHIKTEDPRYLYWADYLGMLIWEEPANYASWTPQARKRF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCEEEEECCCCCCCCCHHHHHHH
KKEFTRMVKRDYNHPSIIAWSIYNEEWGLEWKLKENKDMQKWVEGFYEYARELDPTRLIC
HHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEE
DNSGWAHVKTDINDYHRYFAVPENHKEWQEDLDNYIIKKPGANYVDGYKYNGEPLIVSEF
CCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHEEECCCCCCCCCEEECCCEEEEECC
GMWGLPEISKIEEAYEELPEWYRGNSKLFSEDFKIPATLKENYKKYNLNKIFKSYDELCY
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHCHHHCCHHHHHHHHHHHHH
LTQERQFRGVKSIIEEMRKRSEIAGYVVTELTDIEWETNGFLDYFRNPKFRNNCINHFNG
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEECCCCHHHHHCCCCHHHHHHHHCCC
QVILAININKHNFWSGEECSFTPIVINNSDKKIQGVFRWYLEESELKGIFPVKIPAYSNQ
EEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
RLDEIKFNFPGDWTGSRGVKLRVELEEEKEVVTSNYEELTVTNRREIKKTGKSLQVKGLS
CCCEEEECCCCCCCCCCCEEEEEEECCHHHHHHCCCCCEEECCHHHHHHCCCCEEEECCC
HEFKNKLKNNGFELKTNNSLVLTDNLTEEVLKEVRNGTRVVFLAENGNRIQDKGYINFTK
HHHHHHHHCCCEEEEECCEEEEECCHHHHHHHHHCCCCEEEEEECCCCEECCCCCEEEEE
LPGGESWDRAATFNFINTDIFDGIPLLKISGWELEDIYPDYKVKNLVDLNCTEIISGNFA
CCCCCCCCCEEEEEEECHHHHCCCCEEEECCCCHHHCCCCCCCCEEECCCHHHHHCCCCC
GWLGDFGATTFVMNWGRGQVLVTTLKLISNYHTHPIASLLLNKLINYFQEHK
HHHHCCCCEEEEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GCIIKELNGLWNFTTDPEKIGEQNEWYINGFEGESVKVPGAWQTYNKEMVTYTGYAWYS
CCHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCEEECCCCHHCCCCCEEEEEEEEEEE
REFNINEAIHEFKRFFLKFEAVDYVSDVWINGKYLGSHEGGYTPFDFEVTEHLKEGDNLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCEEECCCCCCCCCCCHHHHHHHHCCCCEE
VVRVFDPDDNDEIPHGKQGSWYTRVSGIWQDVLLVGYDKTFIENVLITPDIDNKRAITQV
EEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHEECCCHHHHCCEEECCCCCCCCEEEEE
KIKDRDRLVNPRIEFKIDPRVNGNKVEGSKTHTYKYFLDEQELYELEILDLYLWGPESPA
EECCCCCCCCCEEEEEECCCCCCCEECCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCC
LYDMTVILKDGNSIIDSYQTYFGMRKIEYKNGMVYLNHKPLYIRGALDQAFWPKTIYRPE
EEEEEEEEECCCHHHHHHHHHHCCEEEEECCCEEEECCCCEEEEECCCCCCCCCCCCCCC
SEELIKEEILKAKEMGFNLLRKHIKTEDPRYLYWADYLGMLIWEEPANYASWTPQARKRF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCEEEEECCCCCCCCCHHHHHHH
KKEFTRMVKRDYNHPSIIAWSIYNEEWGLEWKLKENKDMQKWVEGFYEYARELDPTRLIC
HHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEE
DNSGWAHVKTDINDYHRYFAVPENHKEWQEDLDNYIIKKPGANYVDGYKYNGEPLIVSEF
CCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHEEECCCCCCCCCEEECCCEEEEECC
GMWGLPEISKIEEAYEELPEWYRGNSKLFSEDFKIPATLKENYKKYNLNKIFKSYDELCY
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHCHHHCCHHHHHHHHHHHHH
LTQERQFRGVKSIIEEMRKRSEIAGYVVTELTDIEWETNGFLDYFRNPKFRNNCINHFNG
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEECCCCHHHHHCCCCHHHHHHHHCCC
QVILAININKHNFWSGEECSFTPIVINNSDKKIQGVFRWYLEESELKGIFPVKIPAYSNQ
EEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
RLDEIKFNFPGDWTGSRGVKLRVELEEEKEVVTSNYEELTVTNRREIKKTGKSLQVKGLS
CCCEEEECCCCCCCCCCCEEEEEEECCHHHHHHCCCCCEEECCHHHHHHCCCCEEEECCC
HEFKNKLKNNGFELKTNNSLVLTDNLTEEVLKEVRNGTRVVFLAENGNRIQDKGYINFTK
HHHHHHHHCCCEEEEECCEEEEECCHHHHHHHHHCCCCEEEEEECCCCEECCCCCEEEEE
LPGGESWDRAATFNFINTDIFDGIPLLKISGWELEDIYPDYKVKNLVDLNCTEIISGNFA
CCCCCCCCCEEEEEEECHHHHCCCCEEEECCCCHHHCCCCCCCCEEECCCHHHHHCCCCC
GWLGDFGATTFVMNWGRGQVLVTTLKLISNYHTHPIASLLLNKLINYFQEHK
HHHHCCCCEEEEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA