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The map label for this gene is hhoB [H]

Identifier: 220932857

GI number: 220932857

Start: 2184958

End: 2185752

Strand: Reverse

Name: hhoB [H]

Synonym: Hore_20250

Alternate gene names: 220932857

Gene position: 2185752-2184958 (Counterclockwise)

Preceding gene: 220932858

Following gene: 220932856

Centisome position: 84.78

GC content: 37.86

Gene sequence:

>795_bases
GTGGATTCCTTGTTTAACAAAAATAATAGAAAGAAGATTAACTGGTATTCGTTTCTCTGGTTTGTAATTATTGCTCTGTT
AGCAGGTATATTAATCATTTACTTTGTCTTCCCATCAATGTTTAAAGGACCCGGTGTTAAGAGAATACCCATTATCTTTG
AAGATGAGTCTGAGAATAAGGTAAAAAGCAGGGGTAATATAACTGAAATCTCAAAAAATGTGTCCCGGGCCGTGGTTAAA
ATAACTACTGGAAAAAAGCCTTCGTTTCTTTTTTTAAAAAGTGAGCAGAGGTTTGGGTCGGGGTTTATAATTACTGATAC
AGGTTATATATTAACAAATTACCATGTGGTTCAGGGAGCTGAGAAAATAAGTGTAGTGATCCCCGACAGGGAGAAGGTCT
ATTCAGGAAAAATGGTTGGAGCCGATGCTAAAAATGACCTGGCTTTAATAAAGATTAATGAAAAGGAATTACCCTTTCTT
GAATTATCAACCTCTCGTCGGTTGAGGGCCGGTGAACTTGTTATTGCTCTGGGCTATCCCCTCGGGTTAGAAAATACCCT
GACTGTTGGAGTGGTAAGTGCCCTCAACAGGAATATATATACAGAAAATGGACAGAAGTTAAGAAACCTGATTCAGGTAG
ATGTTGCCATAAATCCCGGAAACAGTGGTGGCCCTCTCTTAAATGATCAGGGTCAGGTTATAGGTATAAATACTGCTATT
ATAAGGCAGGGATTTGGCATAGGTTTTGCTATTCCTATCAGTACTGTCAGGGGTTTTTTAGAAAATTATTTATAA

Upstream 100 bases:

>100_bases
GGAAGAAGGGTTTATTATTGGTAGAGACCTTGAAGTGGATTTTGCGTATCGAGAAAAGCCTACCCGCCTTTATAGGGTGG
GGTAAAAAGAGGTGTCATCG

Downstream 100 bases:

>100_bases
AAAAATTATTTATAAAGGGAGGACAGGGCTATGAAGATTAATATTATGGCGGTAGGAAAAATAAAGGAGGACTACATTAA
TGCTGGAATAAAAGAATTTT

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDSLFNKNNRKKINWYSFLWFVIIALLAGILIIYFVFPSMFKGPGVKRIPIIFEDESENKVKSRGNITEISKNVSRAVVK
ITTGKKPSFLFLKSEQRFGSGFIITDTGYILTNYHVVQGAEKISVVIPDREKVYSGKMVGADAKNDLALIKINEKELPFL
ELSTSRRLRAGELVIALGYPLGLENTLTVGVVSALNRNIYTENGQKLRNLIQVDVAINPGNSGGPLLNDQGQVIGINTAI
IRQGFGIGFAIPISTVRGFLENYL

Sequences:

>Translated_264_residues
MDSLFNKNNRKKINWYSFLWFVIIALLAGILIIYFVFPSMFKGPGVKRIPIIFEDESENKVKSRGNITEISKNVSRAVVK
ITTGKKPSFLFLKSEQRFGSGFIITDTGYILTNYHVVQGAEKISVVIPDREKVYSGKMVGADAKNDLALIKINEKELPFL
ELSTSRRLRAGELVIALGYPLGLENTLTVGVVSALNRNIYTENGQKLRNLIQVDVAINPGNSGGPLLNDQGQVIGINTAI
IRQGFGIGFAIPISTVRGFLENYL
>Mature_264_residues
MDSLFNKNNRKKINWYSFLWFVIIALLAGILIIYFVFPSMFKGPGVKRIPIIFEDESENKVKSRGNITEISKNVSRAVVK
ITTGKKPSFLFLKSEQRFGSGFIITDTGYILTNYHVVQGAEKISVVIPDREKVYSGKMVGADAKNDLALIKINEKELPFL
ELSTSRRLRAGELVIALGYPLGLENTLTVGVVSALNRNIYTENGQKLRNLIQVDVAINPGNSGGPLLNDQGQVIGINTAI
IRQGFGIGFAIPISTVRGFLENYL

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=214, Percent_Identity=40.6542056074766, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI24308541, Length=168, Percent_Identity=47.6190476190476, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI22129776, Length=206, Percent_Identity=38.3495145631068, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI7019477, Length=198, Percent_Identity=38.3838383838384, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI1786356, Length=165, Percent_Identity=47.8787878787879, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789629, Length=173, Percent_Identity=45.0867052023121, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789630, Length=162, Percent_Identity=40.1234567901235, Blast_Score=105, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646839, Length=167, Percent_Identity=43.7125748502994, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 29242; Mature: 29242

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLFNKNNRKKINWYSFLWFVIIALLAGILIIYFVFPSMFKGPGVKRIPIIFEDESENK
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCH
VKSRGNITEISKNVSRAVVKITTGKKPSFLFLKSEQRFGSGFIITDTGYILTNYHVVQGA
HHHCCCHHHHHHHHCEEEEEEECCCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEECCC
EKISVVIPDREKVYSGKMVGADAKNDLALIKINEKELPFLELSTSRRLRAGELVIALGYP
CEEEEEECCHHHHCCCCEECCCCCCCEEEEEECCCCCCEEEECCCCCEECCCEEEEEECC
LGLENTLTVGVVSALNRNIYTENGQKLRNLIQVDVAINPGNSGGPLLNDQGQVIGINTAI
CCCCCHHHHHHHHHHCCCEECCCCHHHHCEEEEEEEECCCCCCCCEECCCCCEEEEEHHH
IRQGFGIGFAIPISTVRGFLENYL
HHCCCCCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MDSLFNKNNRKKINWYSFLWFVIIALLAGILIIYFVFPSMFKGPGVKRIPIIFEDESENK
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCH
VKSRGNITEISKNVSRAVVKITTGKKPSFLFLKSEQRFGSGFIITDTGYILTNYHVVQGA
HHHCCCHHHHHHHHCEEEEEEECCCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEECCC
EKISVVIPDREKVYSGKMVGADAKNDLALIKINEKELPFLELSTSRRLRAGELVIALGYP
CEEEEEECCHHHHCCCCEECCCCCCCEEEEEECCCCCCEEEECCCCCEECCCEEEEEECC
LGLENTLTVGVVSALNRNIYTENGQKLRNLIQVDVAINPGNSGGPLLNDQGQVIGINTAI
CCCCCHHHHHHHHHHCCCEECCCCHHHHCEEEEEEEECCCCCCCCEECCCCCEEEEEHHH
IRQGFGIGFAIPISTVRGFLENYL
HHCCCCCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]