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The map label for this gene is vraR [H]

Identifier: 220932804

GI number: 220932804

Start: 2117748

End: 2118377

Strand: Reverse

Name: vraR [H]

Synonym: Hore_19700

Alternate gene names: 220932804

Gene position: 2118377-2117748 (Counterclockwise)

Preceding gene: 220932805

Following gene: 220932803

Centisome position: 82.17

GC content: 44.29

Gene sequence:

>630_bases
ATGATACAGGTATACCTGGTTGATGATCATCCATTTGTCCTTCAGGGGTTGAAAGCATATTTAAATACCCGGGAGGGAAT
TGAAATTGTTGGGACATCAGGTAATGGAGAAAAGGCCATTAAAGAAATTGCAAAATTAAATCCAGAGGTGGCGGTGGTCG
ATCTGCGGCTTCCCGGGCTTAACGGGATTGAAGTTACCAGGGAGATAAAAAAGAAAAACCCCGGGACTGAAGTTATCATT
CTTTCCAGTTTTAATAAAGAGGATGAGGTAATTGAGGCCATAGATGCCGGAGCCTTAAGTTATGTAATGAAGGATTCCCG
TCCCGAAAAACTGGTTGAGGCTATAAAGGCAGCCCGGCGGGGGGAACCTGTTTTAACCCCTGGTGTTGCCAAAAAAATCA
TGAAAAGGGCAGCCCGGAAGGGACGTAAGACAGAGCCACTAACACCCCGTGAGAAGGAAGTCCTGGCGTGCCTTGTCAGG
GGTAATTCTAACCGTGATATAGCCAAAACCCTGTGCATATCTGAGACTACTGTTAAAACCCATGTCAGTAATATTTTAAA
GAAACTGGATGTTAAAGACCGGACTCAGGCAGTTATTAAGGCTATAGAAAATAATCTGGTAGATAGGTGA

Upstream 100 bases:

>100_bases
ATTACAATTGATTTTTTTTCAAAGAATTTTTCCTGTTATAAAGGCTGATCTCATAAATTTTTACTGTGTAATTGTTTATT
TATCAAAAAGGGGTGTTTGT

Downstream 100 bases:

>100_bases
TATTAATGAGAAAAAGTATTCTGGCTATAACTAAGAATTCTTTTAAAAGTGGTATTATTGGTATCGGGATATCACTTATG
TTTTTCTTTTCATTTTCTGG

Product: two component transcriptional regulator, LuxR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIQVYLVDDHPFVLQGLKAYLNTREGIEIVGTSGNGEKAIKEIAKLNPEVAVVDLRLPGLNGIEVTREIKKKNPGTEVII
LSSFNKEDEVIEAIDAGALSYVMKDSRPEKLVEAIKAARRGEPVLTPGVAKKIMKRAARKGRKTEPLTPREKEVLACLVR
GNSNRDIAKTLCISETTVKTHVSNILKKLDVKDRTQAVIKAIENNLVDR

Sequences:

>Translated_209_residues
MIQVYLVDDHPFVLQGLKAYLNTREGIEIVGTSGNGEKAIKEIAKLNPEVAVVDLRLPGLNGIEVTREIKKKNPGTEVII
LSSFNKEDEVIEAIDAGALSYVMKDSRPEKLVEAIKAARRGEPVLTPGVAKKIMKRAARKGRKTEPLTPREKEVLACLVR
GNSNRDIAKTLCISETTVKTHVSNILKKLDVKDRTQAVIKAIENNLVDR
>Mature_209_residues
MIQVYLVDDHPFVLQGLKAYLNTREGIEIVGTSGNGEKAIKEIAKLNPEVAVVDLRLPGLNGIEVTREIKKKNPGTEVII
LSSFNKEDEVIEAIDAGALSYVMKDSRPEKLVEAIKAARRGEPVLTPGVAKKIMKRAARKGRKTEPLTPREKEVLACLVR
GNSNRDIAKTLCISETTVKTHVSNILKKLDVKDRTQAVIKAIENNLVDR

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=36.8932038834951, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI1787473, Length=200, Percent_Identity=36, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=31.0880829015544, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788222, Length=212, Percent_Identity=27.8301886792453, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788712, Length=187, Percent_Identity=28.8770053475936, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1788546, Length=195, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787277, Length=200, Percent_Identity=31, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786747, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1789937, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI87082052, Length=127, Percent_Identity=28.3464566929134, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23057; Mature: 23057

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVYLVDDHPFVLQGLKAYLNTREGIEIVGTSGNGEKAIKEIAKLNPEVAVVDLRLPGL
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCC
NGIEVTREIKKKNPGTEVIILSSFNKEDEVIEAIDAGALSYVMKDSRPEKLVEAIKAARR
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GEPVLTPGVAKKIMKRAARKGRKTEPLTPREKEVLACLVRGNSNRDIAKTLCISETTVKT
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCHHHHHH
HVSNILKKLDVKDRTQAVIKAIENNLVDR
HHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIQVYLVDDHPFVLQGLKAYLNTREGIEIVGTSGNGEKAIKEIAKLNPEVAVVDLRLPGL
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCC
NGIEVTREIKKKNPGTEVIILSSFNKEDEVIEAIDAGALSYVMKDSRPEKLVEAIKAARR
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GEPVLTPGVAKKIMKRAARKGRKTEPLTPREKEVLACLVRGNSNRDIAKTLCISETTVKT
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCHHHHHH
HVSNILKKLDVKDRTQAVIKAIENNLVDR
HHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]