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The map label for this gene is yitJ [H]

Identifier: 220932792

GI number: 220932792

Start: 2102982

End: 2103911

Strand: Reverse

Name: yitJ [H]

Synonym: Hore_19580

Alternate gene names: 220932792

Gene position: 2103911-2102982 (Counterclockwise)

Preceding gene: 220932793

Following gene: 220932791

Centisome position: 81.61

GC content: 42.8

Gene sequence:

>930_bases
ATGAGCAGGGAGGAGAGAGTAGAGTTGGATTTTAGCAGGGTTTTAACGGAAAGGGAATTTATTGTTACAGCTGAGCTAGA
TCCACCAAGAGGGGTCAATACTGAGGATGTAGTGGAGAAGGTTAAATACCTGTCAGATTATGTGGATGCCATTAATTTTA
CTGATTCACCCATGGCCAGGATGAAAATGAATCCAGTGGCTTTGACCCATCACCTTAAAAATAAGTTTAATTTTAAGGTT
GATTTTATCTGTCATTTGACCGGTCGGGATCGAAACCTCATTGGGTTACAGAGTGAGCTTCTCGGTGGGGCCCTTCTGGG
TGTCAAAAATTATTTGTTCCTGACCGGAGATAAACCGGAATATGGGGATCACCCTTCCAGCACAGGTGTTTTCGATTGTG
ATGGAACCGCTCTTGTAAAACTGGCCAATCAGTTGAACGGGGGTCGGGATTATGCAGGTAATCCTTTAAATGGACCCCTG
GATATTACCATCGGGGCCGGTATTAACCCCGGTGGTAATCTGACGGTTGAAATTGAGAAACTTAAATCCAGAATCGGCTC
CGGGGCCCGTTTTATTCAGACCCAGATAGTTTATGACCCCGGGGTAGTGATTAATTTTATGGAAAGGATTAAAACAATAG
AGGCTTTATGGCCGGTAAAACCCAGGATTTTATTCGGGATTATGCCTCTTAAAAATTATAAAATGGCCACATATATTCAT
GAAAATGTCCCGGGCGTTGACATACCGGCTCCGGTCATGAAGGCAATAAAAAAGGGTGATGAAAGGACCGGAATAAAACT
GGCGAAAGAATTTGTTCTAAATATTAAGGATTATGTTGACGGAATTCATATTATGCCCATGGGAAGAATGGAAGTCGTCA
GTGAGCTGGTTGATGCTATTTTGACAGAGGGTAATCGGGCAATATTATAG

Upstream 100 bases:

>100_bases
TGAGGATTTTGCCCGGGAGATAGGGGCTGACCTCTATGCCGGTGATGCCCTCGATGGGGTAAGGAAAGTAAAAAAATATC
TAAATTTAAATTAATGTCCT

Downstream 100 bases:

>100_bases
GGGGATTATGGTAAGGAATAAAAAGAGTTGTAACAGGATAATAAGGTAATTACAGGGAGGAATTATAAATGAATAAAAAG
ACAAAAAAGCAGTATGGATT

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSREERVELDFSRVLTEREFIVTAELDPPRGVNTEDVVEKVKYLSDYVDAINFTDSPMARMKMNPVALTHHLKNKFNFKV
DFICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDKPEYGDHPSSTGVFDCDGTALVKLANQLNGGRDYAGNPLNGPL
DITIGAGINPGGNLTVEIEKLKSRIGSGARFIQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNYKMATYIH
ENVPGVDIPAPVMKAIKKGDERTGIKLAKEFVLNIKDYVDGIHIMPMGRMEVVSELVDAILTEGNRAIL

Sequences:

>Translated_309_residues
MSREERVELDFSRVLTEREFIVTAELDPPRGVNTEDVVEKVKYLSDYVDAINFTDSPMARMKMNPVALTHHLKNKFNFKV
DFICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDKPEYGDHPSSTGVFDCDGTALVKLANQLNGGRDYAGNPLNGPL
DITIGAGINPGGNLTVEIEKLKSRIGSGARFIQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNYKMATYIH
ENVPGVDIPAPVMKAIKKGDERTGIKLAKEFVLNIKDYVDGIHIMPMGRMEVVSELVDAILTEGNRAIL
>Mature_308_residues
SREERVELDFSRVLTEREFIVTAELDPPRGVNTEDVVEKVKYLSDYVDAINFTDSPMARMKMNPVALTHHLKNKFNFKVD
FICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDKPEYGDHPSSTGVFDCDGTALVKLANQLNGGRDYAGNPLNGPLD
ITIGAGINPGGNLTVEIEKLKSRIGSGARFIQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNYKMATYIHE
NVPGVDIPAPVMKAIKKGDERTGIKLAKEFVLNIKDYVDGIHIMPMGRMEVVSELVDAILTEGNRAIL

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 34299; Mature: 34168

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREERVELDFSRVLTEREFIVTAELDPPRGVNTEDVVEKVKYLSDYVDAINFTDSPMAR
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHH
MKMNPVALTHHLKNKFNFKVDFICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDKPE
HCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCEECHHHHHHHHHHCCCCCEEEEECCCCC
YGDHPSSTGVFDCDGTALVKLANQLNGGRDYAGNPLNGPLDITIGAGINPGGNLTVEIEK
CCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEHHH
LKSRIGSGARFIQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNYKMATYIH
HHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEE
ENVPGVDIPAPVMKAIKKGDERTGIKLAKEFVLNIKDYVDGIHIMPMGRMEVVSELVDAI
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
LTEGNRAIL
HCCCCCCCC
>Mature Secondary Structure 
SREERVELDFSRVLTEREFIVTAELDPPRGVNTEDVVEKVKYLSDYVDAINFTDSPMAR
CCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHH
MKMNPVALTHHLKNKFNFKVDFICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDKPE
HCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCEECHHHHHHHHHHCCCCCEEEEECCCCC
YGDHPSSTGVFDCDGTALVKLANQLNGGRDYAGNPLNGPLDITIGAGINPGGNLTVEIEK
CCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEHHH
LKSRIGSGARFIQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNYKMATYIH
HHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEE
ENVPGVDIPAPVMKAIKKGDERTGIKLAKEFVLNIKDYVDGIHIMPMGRMEVVSELVDAI
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
LTEGNRAIL
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]