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The map label for this gene is cat2 [H]

Identifier: 220932740

GI number: 220932740

Start: 2036671

End: 2037957

Strand: Reverse

Name: cat2 [H]

Synonym: Hore_19050

Alternate gene names: 220932740

Gene position: 2037957-2036671 (Counterclockwise)

Preceding gene: 220932741

Following gene: 220932739

Centisome position: 79.05

GC content: 45.3

Gene sequence:

>1287_bases
ATGGATTTTCAAAAATTATATAGAGAAAAGCTTGTTACAGCCAGAGATGCTGCTGGTAGGGTTAAATCAGGAGATAGAAT
CGTGGTGGCCCTGGGGTGTGGTGAAACCCCGGCTATCCTGGAAAACCTTGCCGATAGGGCTTCAGAGCTTGAGGGTGTTA
TGGTTGATCAGATGCTACCCCTGTATAATTATTCATACTTTAAAAAAGGTATGGAAGATTCCATCAGGCATAATGCCTGG
TTTATTAGTAGTCTGTCAAGGGGTATAGTTAACGAAGGGCGGGCCGATTTCACCCCTAATTTTTTCCATGAGGCCCCCGG
GTTGTACAGGGAGTTTATTGATGTTGATATTCTACTGGCTACCGTTTCCCCGATGGATAAACATGGTTACTTTAGTTTCG
GGGTTTCGGTGGATTATACCAAAGAGGTGGCGGAACAGGCCCGGATGGTTATTGTTGAAGTTAATGAAAATATGCCCCGG
ACCCTGGGAAATTCATTTATCCATATAAGTGAGATTGACTTTCTGGTTGAGCATAATCGGCCTTTACCGGAACTACCGGT
TAATACTCCCAGTGAGGTTGAACTTAAAATCGGGGAATATGTGGCCAGCCTGATTGAAGATGGTTCTACTCTGCAACTGG
GAATTGGTGGAATTCCAAATGCGGTAACAGCAGCCCTTACTGATAAAAAGGACCTCGGGATTCACAGTGAAATGTTGACC
GACGGCATGGTTGAACTGGTTGAAAAGGGAGTAGTCACCAATAGAAAGAAGACCCTTCATCCCGGTAAAATCATTGGATC
TTTTGCCGCCGGGACGAACCGGCTTTATGAATTCCTTGACGATAACCCCATGGTTGAGATGCACCCTGTTTCTTATACCA
ATGATCCCTGGGTAATCAGTCAAAACCACAAAATGGTTTCTGTTAATTCAGCTATAGAAGTTGATCTACTTGGTCAGTGT
GCTGCAGAGACGGTAGGAACCAGACAGATAAGTGGTACCGGCGGTCAGCTTGACTTTGTCAGGGGAGCAGTTAAATCAAA
CGGGGGCAAGAGTATTATTGCTCTGCCATCAACGGCTGGTAATGGTAAGTATTCTACTATTGTTCCCACCCTTAGGGAGG
GAGCTGTAGTTACCACCGGTAAAAATGATGTTGACTATGTGGTTACTGAATACGGTATAGCTCATCTCCGCGGGAAAACA
GCCCGGGAAAGGGCAGAAGCCCTGATCAGGATAGCCCATCCTGATTTCAGGGATGAGTTACGGAATAAAGCACCATATTT
GTATTAG

Upstream 100 bases:

>100_bases
TCTCGGACGGAATGGTTATGAAGATAAGAAGGAAGAGTATTTTAATAGGCCGGAAAAGAATGATAATTTGATTATTTAAG
AAGGGAGCAGGGAGAAGAGG

Downstream 100 bases:

>100_bases
TTCTAATATTGACCATCACTGCCACCAAAATCAAAATTCCCTGCCGTTGAACATGAAAATAGTTAATTGTAAAAAAGAGA
AATATAAAAGGATGTAAAAA

Product: acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDFQKLYREKLVTARDAAGRVKSGDRIVVALGCGETPAILENLADRASELEGVMVDQMLPLYNYSYFKKGMEDSIRHNAW
FISSLSRGIVNEGRADFTPNFFHEAPGLYREFIDVDILLATVSPMDKHGYFSFGVSVDYTKEVAEQARMVIVEVNENMPR
TLGNSFIHISEIDFLVEHNRPLPELPVNTPSEVELKIGEYVASLIEDGSTLQLGIGGIPNAVTAALTDKKDLGIHSEMLT
DGMVELVEKGVVTNRKKTLHPGKIIGSFAAGTNRLYEFLDDNPMVEMHPVSYTNDPWVISQNHKMVSVNSAIEVDLLGQC
AAETVGTRQISGTGGQLDFVRGAVKSNGGKSIIALPSTAGNGKYSTIVPTLREGAVVTTGKNDVDYVVTEYGIAHLRGKT
ARERAEALIRIAHPDFRDELRNKAPYLY

Sequences:

>Translated_428_residues
MDFQKLYREKLVTARDAAGRVKSGDRIVVALGCGETPAILENLADRASELEGVMVDQMLPLYNYSYFKKGMEDSIRHNAW
FISSLSRGIVNEGRADFTPNFFHEAPGLYREFIDVDILLATVSPMDKHGYFSFGVSVDYTKEVAEQARMVIVEVNENMPR
TLGNSFIHISEIDFLVEHNRPLPELPVNTPSEVELKIGEYVASLIEDGSTLQLGIGGIPNAVTAALTDKKDLGIHSEMLT
DGMVELVEKGVVTNRKKTLHPGKIIGSFAAGTNRLYEFLDDNPMVEMHPVSYTNDPWVISQNHKMVSVNSAIEVDLLGQC
AAETVGTRQISGTGGQLDFVRGAVKSNGGKSIIALPSTAGNGKYSTIVPTLREGAVVTTGKNDVDYVVTEYGIAHLRGKT
ARERAEALIRIAHPDFRDELRNKAPYLY
>Mature_428_residues
MDFQKLYREKLVTARDAAGRVKSGDRIVVALGCGETPAILENLADRASELEGVMVDQMLPLYNYSYFKKGMEDSIRHNAW
FISSLSRGIVNEGRADFTPNFFHEAPGLYREFIDVDILLATVSPMDKHGYFSFGVSVDYTKEVAEQARMVIVEVNENMPR
TLGNSFIHISEIDFLVEHNRPLPELPVNTPSEVELKIGEYVASLIEDGSTLQLGIGGIPNAVTAALTDKKDLGIHSEMLT
DGMVELVEKGVVTNRKKTLHPGKIIGSFAAGTNRLYEFLDDNPMVEMHPVSYTNDPWVISQNHKMVSVNSAIEVDLLGQC
AAETVGTRQISGTGGQLDFVRGAVKSNGGKSIIALPSTAGNGKYSTIVPTLREGAVVTTGKNDVDYVVTEYGIAHLRGKT
ARERAEALIRIAHPDFRDELRNKAPYLY

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=219, Percent_Identity=31.0502283105023, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563853, Length=424, Percent_Identity=42.9245283018868, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17538151, Length=428, Percent_Identity=39.4859813084112, Blast_Score=298, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319456, Length=387, Percent_Identity=27.390180878553, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358615, Length=421, Percent_Identity=45.3681710213777, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 47067; Mature: 47067

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFQKLYREKLVTARDAAGRVKSGDRIVVALGCGETPAILENLADRASELEGVMVDQMLP
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
LYNYSYFKKGMEDSIRHNAWFISSLSRGIVNEGRADFTPNFFHEAPGLYREFIDVDILLA
HHCHHHHHHCHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHEEEEE
TVSPMDKHGYFSFGVSVDYTKEVAEQARMVIVEVNENMPRTLGNSFIHISEIDFLVEHNR
ECCCCCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCCCHHHCCCEEEEEHEEEEEECCC
PLPELPVNTPSEVELKIGEYVASLIEDGSTLQLGIGGIPNAVTAALTDKKDLGIHSEMLT
CCCCCCCCCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCHHHHHH
DGMVELVEKGVVTNRKKTLHPGKIIGSFAAGTNRLYEFLDDNPMVEMHPVSYTNDPWVIS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEE
QNHKMVSVNSAIEVDLLGQCAAETVGTRQISGTGGQLDFVRGAVKSNGGKSIIALPSTAG
CCCEEEEECCEEEEEHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCC
NGKYSTIVPTLREGAVVTTGKNDVDYVVTEYGIAHLRGKTARERAEALIRIAHPDFRDEL
CCCEEEECCHHCCCEEEECCCCCCCEEEHHHCHHHHCCCHHHHHHHHHEEECCCCHHHHH
RNKAPYLY
HHCCCCCC
>Mature Secondary Structure
MDFQKLYREKLVTARDAAGRVKSGDRIVVALGCGETPAILENLADRASELEGVMVDQMLP
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
LYNYSYFKKGMEDSIRHNAWFISSLSRGIVNEGRADFTPNFFHEAPGLYREFIDVDILLA
HHCHHHHHHCHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHEEEEE
TVSPMDKHGYFSFGVSVDYTKEVAEQARMVIVEVNENMPRTLGNSFIHISEIDFLVEHNR
ECCCCCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCCCHHHCCCEEEEEHEEEEEECCC
PLPELPVNTPSEVELKIGEYVASLIEDGSTLQLGIGGIPNAVTAALTDKKDLGIHSEMLT
CCCCCCCCCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCHHHHHH
DGMVELVEKGVVTNRKKTLHPGKIIGSFAAGTNRLYEFLDDNPMVEMHPVSYTNDPWVIS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEE
QNHKMVSVNSAIEVDLLGQCAAETVGTRQISGTGGQLDFVRGAVKSNGGKSIIALPSTAG
CCCEEEEECCEEEEEHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCC
NGKYSTIVPTLREGAVVTTGKNDVDYVVTEYGIAHLRGKTARERAEALIRIAHPDFRDEL
CCCEEEECCHHCCCEEEECCCCCCCEEEHHHCHHHHCCCHHHHHHHHHEEECCCCHHHHH
RNKAPYLY
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]