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The map label for this gene is pgi [H]

Identifier: 220932741

GI number: 220932741

Start: 2037979

End: 2039418

Strand: Reverse

Name: pgi [H]

Synonym: Hore_19060

Alternate gene names: 220932741

Gene position: 2039418-2037979 (Counterclockwise)

Preceding gene: 220932742

Following gene: 220932740

Centisome position: 79.1

GC content: 42.08

Gene sequence:

>1440_bases
ATGTCTAAAAGGTTTCAGGATAAGAACTGGTGTCAGAGGATGAGAATAAGGCTGGATGTAAATAATATGTTTTCTGAAAT
GGTGGGTGAAGAACATGGGTTATTAAGGAAAGAAGTCGATGACCTTAAAGAAGAGATCAAAAAGGCCCATGAAAACATCC
ATAGGGCTAAAAATGAAGGCAAAATGGGTTTTATGGAATTGCCATTTACCCAGAAGGAAGTTGTTGAAGAGATCAGGAGT
CTGGCCAATGAACTTAAAGGTAAATTTGATAACTTTGTTGTCCTGGGCATAGGTGGTTCAGCTCTGGGTAATATAGCCCT
ACAGACTGCCCTGAATGATCCCTATTATAACTACAAGTCAGAGGCAAGGGATAACAGGCCCCGCCTTTTTGTTCCTGATA
ACGTGGACCCGGCAAGGTTTAAAAGTTTACTGGAAACCCTTGACCTGAAGAGGACTATCTTTAATGTAATTTCTAAATCT
GGAAGTACCGCTGAGACCATGAGTCAGTTTTTAATTGCCAGGAAAGCAGTGGCTGAAGAAGTGGGAGAGGAAAATGTTTC
CCGGCATTTTATTGCTACAACCAGTCAGGATTCAGGTTATTTGATTAAAATAGCGAAACGGGAAGGGTTTAAAACATTCT
ATATCCCTGAAAATGTTGGAGGCAGGTTCTCTGTGTTAACACCGGTAGGACTTGTTTCAGCTGCTTTCTGCGGTATAGAT
ATTGAAGAACTTCTGGCCGGTGCTGCCTATATGGATGAAATATGCAGGACCGAAAATGTCTGGGAAAACCCGGCTTACTT
AAATGGGGTATTACAGTACCTGGCCTATAAAAAGGGTAAGCCTTTATCGGTTATGATGCCATATGTTCATGCCCTGAAGG
ATGTTGCTGACTGGTATAGACAGTTATGGGCTGAGTCTCTGGGTAAGAAGGTCGACCGTGAAGGAAATGTTGTTAATGTA
GGGCCAACCCCGATAAAAGCCCTGGGAGCCACTGACCAGCATTCCCAGGTCCAGCTATATATGGAAGGTCCCTATGACAA
GGTTATTACCTTCCTGGAAGTAAAGGATTATGGTGCTGAGGTTGAGATTCCCGGGTCCTATAAAGATATTGAAGGGGTTT
CATATCTCGGTGGCCATACCCTTAACGAACTAATCCAGACCGAAAAGAGGGCAACTGAACTGGCGTTAACCAAAAATGGA
CGGTTAAACTGTACTATTACCCTGCCTGAAGTAAATGAATTTACCATGGGTCAGTTATTATATATGTTTGAACTCCAGAC
CGCACTGGTTGGAGAGCTATTAAATATAAATGCCTTTAACCAGCCTGGAGTAGAGCTGGGCAAACATTATACCTATGGTG
TTCTCGGACGGAATGGTTATGAAGATAAGAAGGAAGAGTATTTTAATAGGCCGGAAAAGAATGATAATTTGATTATTTAA

Upstream 100 bases:

>100_bases
TGAAAAACGTTTGCGCAAATTGTATACTGTTAGGGAAAGTTAACGAAAATAATACATAATTTTATCAAAAGGTTAATAAA
TAGTAAGGGGGAATAAAAAA

Downstream 100 bases:

>100_bases
GAAGGGAGCAGGGAGAAGAGGATGGATTTTCAAAAATTATATAGAGAAAAGCTTGTTACAGCCAGAGATGCTGCTGGTAG
GGTTAAATCAGGAGATAGAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSKRFQDKNWCQRMRIRLDVNNMFSEMVGEEHGLLRKEVDDLKEEIKKAHENIHRAKNEGKMGFMELPFTQKEVVEEIRS
LANELKGKFDNFVVLGIGGSALGNIALQTALNDPYYNYKSEARDNRPRLFVPDNVDPARFKSLLETLDLKRTIFNVISKS
GSTAETMSQFLIARKAVAEEVGEENVSRHFIATTSQDSGYLIKIAKREGFKTFYIPENVGGRFSVLTPVGLVSAAFCGID
IEELLAGAAYMDEICRTENVWENPAYLNGVLQYLAYKKGKPLSVMMPYVHALKDVADWYRQLWAESLGKKVDREGNVVNV
GPTPIKALGATDQHSQVQLYMEGPYDKVITFLEVKDYGAEVEIPGSYKDIEGVSYLGGHTLNELIQTEKRATELALTKNG
RLNCTITLPEVNEFTMGQLLYMFELQTALVGELLNINAFNQPGVELGKHYTYGVLGRNGYEDKKEEYFNRPEKNDNLII

Sequences:

>Translated_479_residues
MSKRFQDKNWCQRMRIRLDVNNMFSEMVGEEHGLLRKEVDDLKEEIKKAHENIHRAKNEGKMGFMELPFTQKEVVEEIRS
LANELKGKFDNFVVLGIGGSALGNIALQTALNDPYYNYKSEARDNRPRLFVPDNVDPARFKSLLETLDLKRTIFNVISKS
GSTAETMSQFLIARKAVAEEVGEENVSRHFIATTSQDSGYLIKIAKREGFKTFYIPENVGGRFSVLTPVGLVSAAFCGID
IEELLAGAAYMDEICRTENVWENPAYLNGVLQYLAYKKGKPLSVMMPYVHALKDVADWYRQLWAESLGKKVDREGNVVNV
GPTPIKALGATDQHSQVQLYMEGPYDKVITFLEVKDYGAEVEIPGSYKDIEGVSYLGGHTLNELIQTEKRATELALTKNG
RLNCTITLPEVNEFTMGQLLYMFELQTALVGELLNINAFNQPGVELGKHYTYGVLGRNGYEDKKEEYFNRPEKNDNLII
>Mature_478_residues
SKRFQDKNWCQRMRIRLDVNNMFSEMVGEEHGLLRKEVDDLKEEIKKAHENIHRAKNEGKMGFMELPFTQKEVVEEIRSL
ANELKGKFDNFVVLGIGGSALGNIALQTALNDPYYNYKSEARDNRPRLFVPDNVDPARFKSLLETLDLKRTIFNVISKSG
STAETMSQFLIARKAVAEEVGEENVSRHFIATTSQDSGYLIKIAKREGFKTFYIPENVGGRFSVLTPVGLVSAAFCGIDI
EELLAGAAYMDEICRTENVWENPAYLNGVLQYLAYKKGKPLSVMMPYVHALKDVADWYRQLWAESLGKKVDREGNVVNVG
PTPIKALGATDQHSQVQLYMEGPYDKVITFLEVKDYGAEVEIPGSYKDIEGVSYLGGHTLNELIQTEKRATELALTKNGR
LNCTITLPEVNEFTMGQLLYMFELQTALVGELLNINAFNQPGVELGKHYTYGVLGRNGYEDKKEEYFNRPEKNDNLII

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=406, Percent_Identity=26.1083743842365, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI296080693, Length=347, Percent_Identity=25.9365994236311, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1790457, Length=391, Percent_Identity=28.9002557544757, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71996703, Length=394, Percent_Identity=28.1725888324873, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996708, Length=395, Percent_Identity=28.1012658227848, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319673, Length=409, Percent_Identity=28.6063569682152, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651916, Length=392, Percent_Identity=28.3163265306122, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24651914, Length=392, Percent_Identity=28.3163265306122, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17737445, Length=392, Percent_Identity=28.3163265306122, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 54177; Mature: 54046

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRFQDKNWCQRMRIRLDVNNMFSEMVGEEHGLLRKEVDDLKEEIKKAHENIHRAKNEG
CCCCCCCHHHHHHHHEEECHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KMGFMELPFTQKEVVEEIRSLANELKGKFDNFVVLGIGGSALGNIALQTALNDPYYNYKS
CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCH
EARDNRPRLFVPDNVDPARFKSLLETLDLKRTIFNVISKSGSTAETMSQFLIARKAVAEE
HCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VGEENVSRHFIATTSQDSGYLIKIAKREGFKTFYIPENVGGRFSVLTPVGLVSAAFCGID
HCHHHHCCEEEEECCCCCCEEEEEEECCCCEEEECCCCCCCCEEEHHHHHHHHHHHCCCC
IEELLAGAAYMDEICRTENVWENPAYLNGVLQYLAYKKGKPLSVMMPYVHALKDVADWYR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QLWAESLGKKVDREGNVVNVGPTPIKALGATDQHSQVQLYMEGPYDKVITFLEVKDYGAE
HHHHHHHHHHCCCCCCEEECCCCCHHHCCCCCCCCEEEEEEECCHHHHEEEEEEECCCCE
VEIPGSYKDIEGVSYLGGHTLNELIQTEKRATELALTKNGRLNCTITLPEVNEFTMGQLL
EECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHHHH
YMFELQTALVGELLNINAFNQPGVELGKHYTYGVLGRNGYEDKKEEYFNRPEKNDNLII
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SKRFQDKNWCQRMRIRLDVNNMFSEMVGEEHGLLRKEVDDLKEEIKKAHENIHRAKNEG
CCCCCCHHHHHHHHEEECHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KMGFMELPFTQKEVVEEIRSLANELKGKFDNFVVLGIGGSALGNIALQTALNDPYYNYKS
CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCH
EARDNRPRLFVPDNVDPARFKSLLETLDLKRTIFNVISKSGSTAETMSQFLIARKAVAEE
HCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VGEENVSRHFIATTSQDSGYLIKIAKREGFKTFYIPENVGGRFSVLTPVGLVSAAFCGID
HCHHHHCCEEEEECCCCCCEEEEEEECCCCEEEECCCCCCCCEEEHHHHHHHHHHHCCCC
IEELLAGAAYMDEICRTENVWENPAYLNGVLQYLAYKKGKPLSVMMPYVHALKDVADWYR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QLWAESLGKKVDREGNVVNVGPTPIKALGATDQHSQVQLYMEGPYDKVITFLEVKDYGAE
HHHHHHHHHHCCCCCCEEECCCCCHHHCCCCCCCCEEEEEEECCHHHHEEEEEEECCCCE
VEIPGSYKDIEGVSYLGGHTLNELIQTEKRATELALTKNGRLNCTITLPEVNEFTMGQLL
EECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHHHH
YMFELQTALVGELLNINAFNQPGVELGKHYTYGVLGRNGYEDKKEEYFNRPEKNDNLII
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA