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The map label for this gene is lpxK

Identifier: 220932729

GI number: 220932729

Start: 2023817

End: 2024971

Strand: Reverse

Name: lpxK

Synonym: Hore_18940

Alternate gene names: 220932729

Gene position: 2024971-2023817 (Counterclockwise)

Preceding gene: 220932730

Following gene: 220932728

Centisome position: 78.54

GC content: 40.43

Gene sequence:

>1155_bases
GTGGTAGCTAATATGCGAAAAAAACTGGAATCATATTTAATTAATTTAATAAAATCAGGTCCCAGAAGCATTTGTGATAA
AATAGTCTTATTTATTTTATCAATACTGGAAAAAATATATAATTTACTGATATTATTGAGAAGACTCCTTTACAATCTGA
ATCTGGTAAAACCGGGAGAGGTTGAAGCCCGGGTAATCAGTGTTGGAAATATAACGGCAGGGGGAACAGGCAAGACCCCC
CTGGTAATTTATCTGGCAAAAAAGCTGGCGGAAGAGAATAGGGTTGTTGTTATAAGCCGGGGTTATCAGTCACAATCAGA
AGGTGAAGAACCGTCAGTGGTTTCTGATGGCAGGAATATTTTGACTGATGTTTCTGAAGCCGGGGATGAAGTCTATATGA
TGGCCACTTTACTTGGTGGTGTTCCCCTGATTACCGGGTCAAACCGTTATAAAGCAGCCCGCCTTGCCAGCCGCCGTTTT
AATGCTGAGATTATAATCCTGGATGATGGTTTTCAGCACTGGCAGTTGAAGCGGGATGTTGATATTGTTATGATAGATGG
GTTGAAACCCTTTGGCCAGGGCAGGCTAATACCCCGGGGTTTTTTGCGGGAACCCCTGTCAGGTCTTAAAAGGGCTGATT
TTTTTGTGATATCACGTGCCCATCATATTTCCCGGGAAAAGTTGCAGGAAATTAAAGATACTTTATGTCAGTATAACCAA
AATGCTGTGGTCTATGAAGCTACCACCAGCTCTGTTTATTTAAAGGAGTTATCGGTAGCGAGTCTTGAGATGAAGTCTAT
TATCCATAAAAAACGCCCACTGGATGAGTTAAAAGGAGCTAAAGTTATAGCGGTATGTGGGCTGGGTAATCCGCGGTCTT
TTTACCGTGACCTGGAGATATCAGGGGCAGAGGTCATTGAGACCCTTTCCTTTAATGATCATCACCAGTACAGGCCCGAT
GATTTTGATAAAATAATAAATCTGGCCCGACAAAAGGCTATAGATATAGTAATTACCACTGAAAAGGATGCTGTTAAATT
TAGCAGGGACGATATTAAAAAATTTATTGACCATAATATCAATCTTTATGTCCTGGGAATCGAGATTTCATTAAAAGGGA
CAGTTGATCTGGCACAGGTAATCAATAAATATTAA

Upstream 100 bases:

>100_bases
AAACCCCTTAAATTACCTGAGGGCAAGAGTGTTGAGGAAAAATGCCACCTGGTAGAGGAAAACCTCAGAGAAGTTCAGGC
CCGGGCCAGGGATCTGGTAG

Downstream 100 bases:

>100_bases
AATAACTGTTAACTAAATAACTTAAATTATAAAAAGGTTAGGTGACAGGGATGAATGTTATAGCGGTAATTCCAGCCCGT
TTTTATTCAAGCCGTTTTCC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MVANMRKKLESYLINLIKSGPRSICDKIVLFILSILEKIYNLLILLRRLLYNLNLVKPGEVEARVISVGNITAGGTGKTP
LVIYLAKKLAEENRVVVISRGYQSQSEGEEPSVVSDGRNILTDVSEAGDEVYMMATLLGGVPLITGSNRYKAARLASRRF
NAEIIILDDGFQHWQLKRDVDIVMIDGLKPFGQGRLIPRGFLREPLSGLKRADFFVISRAHHISREKLQEIKDTLCQYNQ
NAVVYEATTSSVYLKELSVASLEMKSIIHKKRPLDELKGAKVIAVCGLGNPRSFYRDLEISGAEVIETLSFNDHHQYRPD
DFDKIINLARQKAIDIVITTEKDAVKFSRDDIKKFIDHNINLYVLGIEISLKGTVDLAQVINKY

Sequences:

>Translated_384_residues
MVANMRKKLESYLINLIKSGPRSICDKIVLFILSILEKIYNLLILLRRLLYNLNLVKPGEVEARVISVGNITAGGTGKTP
LVIYLAKKLAEENRVVVISRGYQSQSEGEEPSVVSDGRNILTDVSEAGDEVYMMATLLGGVPLITGSNRYKAARLASRRF
NAEIIILDDGFQHWQLKRDVDIVMIDGLKPFGQGRLIPRGFLREPLSGLKRADFFVISRAHHISREKLQEIKDTLCQYNQ
NAVVYEATTSSVYLKELSVASLEMKSIIHKKRPLDELKGAKVIAVCGLGNPRSFYRDLEISGAEVIETLSFNDHHQYRPD
DFDKIINLARQKAIDIVITTEKDAVKFSRDDIKKFIDHNINLYVLGIEISLKGTVDLAQVINKY
>Mature_384_residues
MVANMRKKLESYLINLIKSGPRSICDKIVLFILSILEKIYNLLILLRRLLYNLNLVKPGEVEARVISVGNITAGGTGKTP
LVIYLAKKLAEENRVVVISRGYQSQSEGEEPSVVSDGRNILTDVSEAGDEVYMMATLLGGVPLITGSNRYKAARLASRRF
NAEIIILDDGFQHWQLKRDVDIVMIDGLKPFGQGRLIPRGFLREPLSGLKRADFFVISRAHHISREKLQEIKDTLCQYNQ
NAVVYEATTSSVYLKELSVASLEMKSIIHKKRPLDELKGAKVIAVCGLGNPRSFYRDLEISGAEVIETLSFNDHHQYRPD
DFDKIINLARQKAIDIVITTEKDAVKFSRDDIKKFIDHNINLYVLGIEISLKGTVDLAQVINKY

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=344, Percent_Identity=29.0697674418605, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_HALOH (B8CZC3)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509637.1
- GeneID:   7312709
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_18940
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   CLSK2806570
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 43217; Mature: 43217

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVANMRKKLESYLINLIKSGPRSICDKIVLFILSILEKIYNLLILLRRLLYNLNLVKPGE
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VEARVISVGNITAGGTGKTPLVIYLAKKLAEENRVVVISRGYQSQSEGEEPSVVSDGRNI
CCEEEEEECCEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHCCHHH
LTDVSEAGDEVYMMATLLGGVPLITGSNRYKAARLASRRFNAEIIILDDGFQHWQLKRDV
HHHHHHCCCCEEEHHHHHCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCEEECCCC
DIVMIDGLKPFGQGRLIPRGFLREPLSGLKRADFFVISRAHHISREKLQEIKDTLCQYNQ
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHCCC
NAVVYEATTSSVYLKELSVASLEMKSIIHKKRPLDELKGAKVIAVCGLGNPRSFYRDLEI
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCHHHHHHHCCC
SGAEVIETLSFNDHHQYRPDDFDKIINLARQKAIDIVITTEKDAVKFSRDDIKKFIDHNI
CHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCHHHHCCHHHHHHHHCCCC
NLYVLGIEISLKGTVDLAQVINKY
EEEEEEEEEEECCCHHHHHHHHCC
>Mature Secondary Structure
MVANMRKKLESYLINLIKSGPRSICDKIVLFILSILEKIYNLLILLRRLLYNLNLVKPGE
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VEARVISVGNITAGGTGKTPLVIYLAKKLAEENRVVVISRGYQSQSEGEEPSVVSDGRNI
CCEEEEEECCEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHCCHHH
LTDVSEAGDEVYMMATLLGGVPLITGSNRYKAARLASRRFNAEIIILDDGFQHWQLKRDV
HHHHHHCCCCEEEHHHHHCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCEEECCCC
DIVMIDGLKPFGQGRLIPRGFLREPLSGLKRADFFVISRAHHISREKLQEIKDTLCQYNQ
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHCCC
NAVVYEATTSSVYLKELSVASLEMKSIIHKKRPLDELKGAKVIAVCGLGNPRSFYRDLEI
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCHHHHHHHCCC
SGAEVIETLSFNDHHQYRPDDFDKIINLARQKAIDIVITTEKDAVKFSRDDIKKFIDHNI
CHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCHHHHCCHHHHHHHHCCCC
NLYVLGIEISLKGTVDLAQVINKY
EEEEEEEEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA