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The map label for this gene is kdsA [H]

Identifier: 220932727

GI number: 220932727

Start: 2022199

End: 2023038

Strand: Reverse

Name: kdsA [H]

Synonym: Hore_18920

Alternate gene names: 220932727

Gene position: 2023038-2022199 (Counterclockwise)

Preceding gene: 220932728

Following gene: 220932726

Centisome position: 78.47

GC content: 48.45

Gene sequence:

>840_bases
GTGCTGGATAAAGTAAAGAAGGTTAAATTAAATCAAGATATTGTTTTTGGTGATAGCAACAGGCCACTGGTTCTCATCGC
CGGTCCCTGTGTTTTAGAAGAGGAAGACCGGGTTTTAAAAATAGCGGAGACGGTTAAGGAGATTACTTCAAGGCTTGGAA
TTCCATATGTTTTTAAATCATCATATGATAAGGCCAACCGTTCTTCTATAAAATCATTCCGGGGGCCGGGTCTTGAAGAT
GGCCTGAAGTTGCTGGAGAGGGTCAAAAGAGAAGTTGGAGTACCACTCCTAACCGATGTTCATGAGCCAGACCAGGCTGC
TCTGGCGGCTGAAGTGGTTGATATAGTCCAGATTCCGGCCTTTTTGTCACGCCAGACCGATCTGGTGGTTGCTGCCGGAA
GGACCGGGAAGATTGTCAATGTCAAGAAAGGCCAATTCCTGGCTCCCTGGGATATCGACAGGGTAGTGGAAAAGATTGAG
AGTACCGGAAATGAAAAGATTCTTTTAACAGAGCGGGGAGTCAGTTTCGGTTATAATAACCTGGTAGTCGATATGCGCTC
TCTACCCCGGATGAGGGAGACCGGGTATCCAGTAGTTTTTGATGCCACCCATAGTGTCCAGCTGCCAGGGGGTGCCGGTG
AGACCTCCGGTGGGGACAGGAAGTTTGTCCCCTATTTAACCAGGGCTGCTGTAGGGACCGGCGTTGATGCCCTCTTTATG
GAAGTACATGATAACCCCGATGTAGCTTTAAGTGATGGTCCCAACATGGTTCCCCTTGACCAGCTTGAGGGAATCCTGAT
AAAAGCCCTGGCCATTGACGAAATTGTTAAAGGCAGGTGA

Upstream 100 bases:

>100_bases
ATAAAATTAAAGTTGTGGAGACTGAATTTGACTCGATTGGTGTTGATACTCCTGAAGATATAGCCAGGGTGGAAAAAATT
ATGGAGGGGTGTAATTAAAA

Downstream 100 bases:

>100_bases
AGATAAGTGAATGAACCGGTAAACCTCGATGAAAAGATGATAATTGACTGTCTTCAGGAAGCCCGTAAAGTCCTTGAGAT
AGAGGCCTATTCGGTTTTAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MLDKVKKVKLNQDIVFGDSNRPLVLIAGPCVLEEEDRVLKIAETVKEITSRLGIPYVFKSSYDKANRSSIKSFRGPGLED
GLKLLERVKREVGVPLLTDVHEPDQAALAAEVVDIVQIPAFLSRQTDLVVAAGRTGKIVNVKKGQFLAPWDIDRVVEKIE
STGNEKILLTERGVSFGYNNLVVDMRSLPRMRETGYPVVFDATHSVQLPGGAGETSGGDRKFVPYLTRAAVGTGVDALFM
EVHDNPDVALSDGPNMVPLDQLEGILIKALAIDEIVKGR

Sequences:

>Translated_279_residues
MLDKVKKVKLNQDIVFGDSNRPLVLIAGPCVLEEEDRVLKIAETVKEITSRLGIPYVFKSSYDKANRSSIKSFRGPGLED
GLKLLERVKREVGVPLLTDVHEPDQAALAAEVVDIVQIPAFLSRQTDLVVAAGRTGKIVNVKKGQFLAPWDIDRVVEKIE
STGNEKILLTERGVSFGYNNLVVDMRSLPRMRETGYPVVFDATHSVQLPGGAGETSGGDRKFVPYLTRAAVGTGVDALFM
EVHDNPDVALSDGPNMVPLDQLEGILIKALAIDEIVKGR
>Mature_279_residues
MLDKVKKVKLNQDIVFGDSNRPLVLIAGPCVLEEEDRVLKIAETVKEITSRLGIPYVFKSSYDKANRSSIKSFRGPGLED
GLKLLERVKREVGVPLLTDVHEPDQAALAAEVVDIVQIPAFLSRQTDLVVAAGRTGKIVNVKKGQFLAPWDIDRVVEKIE
STGNEKILLTERGVSFGYNNLVVDMRSLPRMRETGYPVVFDATHSVQLPGGAGETSGGDRKFVPYLTRAAVGTGVDALFM
EVHDNPDVALSDGPNMVPLDQLEGILIKALAIDEIVKGR

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=259, Percent_Identity=49.8069498069498, Blast_Score=266, Evalue=1e-72,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30472; Mature: 30472

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKVKKVKLNQDIVFGDSNRPLVLIAGPCVLEEEDRVLKIAETVKEITSRLGIPYVFKS
CCCCCCEEECCCEEEECCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCEEECC
SYDKANRSSIKSFRGPGLEDGLKLLERVKREVGVPLLTDVHEPDQAALAAEVVDIVQIPA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHH
FLSRQTDLVVAAGRTGKIVNVKKGQFLAPWDIDRVVEKIESTGNEKILLTERGVSFGYNN
HHCCCCCEEEEECCCCCEEEECCCCEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCC
LVVDMRSLPRMRETGYPVVFDATHSVQLPGGAGETSGGDRKFVPYLTRAAVGTGVDALFM
EEEEHHHCCHHHHCCCCEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
EVHDNPDVALSDGPNMVPLDQLEGILIKALAIDEIVKGR
EECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDKVKKVKLNQDIVFGDSNRPLVLIAGPCVLEEEDRVLKIAETVKEITSRLGIPYVFKS
CCCCCCEEECCCEEEECCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCEEECC
SYDKANRSSIKSFRGPGLEDGLKLLERVKREVGVPLLTDVHEPDQAALAAEVVDIVQIPA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHH
FLSRQTDLVVAAGRTGKIVNVKKGQFLAPWDIDRVVEKIESTGNEKILLTERGVSFGYNN
HHCCCCCEEEEECCCCCEEEECCCCEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCC
LVVDMRSLPRMRETGYPVVFDATHSVQLPGGAGETSGGDRKFVPYLTRAAVGTGVDALFM
EEEEHHHCCHHHHCCCCEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
EVHDNPDVALSDGPNMVPLDQLEGILIKALAIDEIVKGR
EECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA