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The map label for this gene is upp [H]

Identifier: 220932628

GI number: 220932628

Start: 1917112

End: 1917792

Strand: Reverse

Name: upp [H]

Synonym: Hore_17920

Alternate gene names: 220932628

Gene position: 1917792-1917112 (Counterclockwise)

Preceding gene: 220932629

Following gene: 220932627

Centisome position: 74.39

GC content: 44.05

Gene sequence:

>681_bases
ATGAAAGAAGGGTTAATAAAATTACCAGGATTGAAAGGGGAGAATACTAAAATGGGAAAGGTAACCGTTATCGACCATCC
ACTAATACAACATAAATTAACCCTGATCAGGAATAAAGATACCGGTCCCAAAGAATTCAGGGAACTGGTAGATGAAGTAG
CCACCTTGATGGCCTACGAAGTGACCAGGGATCTACCCCTGGAAGAGGTTGAAGTTGAGACCCCTATTCAGAAGGCCAGA
TTTAAAGTAATATCCGGGAAAAAGCTGGGAGTTGTTCCCATCCTGAGGGCAGGACTCGGTATGCTTGACGGGGTCTTGAA
ACTTATTCCTGCGGCCAAGGTGGGACATATAGGGCTTTACCGTGACCCTGATACATTAAAACCGGTCGAATATTACTGTA
AGCTCCCTTCAGATGTAAATGAGAGGGATTTAATTGTTGTTGATCCTATGCTGGCTACCGGAGGTTCAGCTGCAGCGGCT
ATCAGTTTCATAAAGGAACGTAATCCCAGGAGTATTAAGTTTATGTGTCTTATAGCTGCTCCTGAGGGAGTTGAGAGATT
ACAGGAAGAGCACCCTGATGTCAGTATTTTTACGGCTGCTGTAGATGAGAAGTTAAATGATCATGCCTATATTGTACCTG
GACTTGGTGATGCCGGAGACAGGCTTTATGGTACTAAATGA

Upstream 100 bases:

>100_bases
AATGCCAATGTCCTGGCCCTGGGTTCTAGGGTTATAGGGATAGGTCTGGCTAAAGAGATAGTCAAAACCTGGCTGGAAGC
TGGTTTTGATGGAGACAGGC

Downstream 100 bases:

>100_bases
TTGTTATAAAACCACTAAAAATATTTGTTCCTGTTAGAGGGGATGTTTAAATGTTAAACAGTATTCTGGCCTTTTTACTG
GGCTTACTGGTGACTTTTAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKEGLIKLPGLKGENTKMGKVTVIDHPLIQHKLTLIRNKDTGPKEFRELVDEVATLMAYEVTRDLPLEEVEVETPIQKAR
FKVISGKKLGVVPILRAGLGMLDGVLKLIPAAKVGHIGLYRDPDTLKPVEYYCKLPSDVNERDLIVVDPMLATGGSAAAA
ISFIKERNPRSIKFMCLIAAPEGVERLQEEHPDVSIFTAAVDEKLNDHAYIVPGLGDAGDRLYGTK

Sequences:

>Translated_226_residues
MKEGLIKLPGLKGENTKMGKVTVIDHPLIQHKLTLIRNKDTGPKEFRELVDEVATLMAYEVTRDLPLEEVEVETPIQKAR
FKVISGKKLGVVPILRAGLGMLDGVLKLIPAAKVGHIGLYRDPDTLKPVEYYCKLPSDVNERDLIVVDPMLATGGSAAAA
ISFIKERNPRSIKFMCLIAAPEGVERLQEEHPDVSIFTAAVDEKLNDHAYIVPGLGDAGDRLYGTK
>Mature_226_residues
MKEGLIKLPGLKGENTKMGKVTVIDHPLIQHKLTLIRNKDTGPKEFRELVDEVATLMAYEVTRDLPLEEVEVETPIQKAR
FKVISGKKLGVVPILRAGLGMLDGVLKLIPAAKVGHIGLYRDPDTLKPVEYYCKLPSDVNERDLIVVDPMLATGGSAAAA
ISFIKERNPRSIKFMCLIAAPEGVERLQEEHPDVSIFTAAVDEKLNDHAYIVPGLGDAGDRLYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.6930693069307, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.6930693069307, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=28.2352941176471, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=51.207729468599, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.3781094527363, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.3781094527363, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.0625, Blast_Score=128, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28573516, Length=204, Percent_Identity=30.8823529411765, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28573514, Length=204, Percent_Identity=30.8823529411765, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28573512, Length=204, Percent_Identity=30.8823529411765, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI45550449, Length=204, Percent_Identity=30.8823529411765, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24818; Mature: 24818

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGLIKLPGLKGENTKMGKVTVIDHPLIQHKLTLIRNKDTGPKEFRELVDEVATLMAYE
CCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHH
VTRDLPLEEVEVETPIQKARFKVISGKKLGVVPILRAGLGMLDGVLKLIPAAKVGHIGLY
HHCCCCHHHHCCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RDPDTLKPVEYYCKLPSDVNERDLIVVDPMLATGGSAAAAISFIKERNPRSIKFMCLIAA
CCCCCCCHHHHEECCCCCCCCCCEEEECCHHHCCCCHHHHHHHHHHCCCCCEEEEEEEEC
PEGVERLQEEHPDVSIFTAAVDEKLNDHAYIVPGLGDAGDRLYGTK
CHHHHHHHHHCCCEEEEEEEHHHCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKEGLIKLPGLKGENTKMGKVTVIDHPLIQHKLTLIRNKDTGPKEFRELVDEVATLMAYE
CCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHH
VTRDLPLEEVEVETPIQKARFKVISGKKLGVVPILRAGLGMLDGVLKLIPAAKVGHIGLY
HHCCCCHHHHCCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RDPDTLKPVEYYCKLPSDVNERDLIVVDPMLATGGSAAAAISFIKERNPRSIKFMCLIAA
CCCCCCCHHHHEECCCCCCCCCCEEEECCHHHCCCCHHHHHHHHHHCCCCCEEEEEEEEC
PEGVERLQEEHPDVSIFTAAVDEKLNDHAYIVPGLGDAGDRLYGTK
CHHHHHHHHHCCCEEEEEEEHHHCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA